Subglottic Stenosis: Development of a Clinically Relevant Endoscopic Animal Model

2020 ◽  
Vol 162 (6) ◽  
pp. 905-913
Author(s):  
Leila J. Mady ◽  
Matthew Criado ◽  
James Park ◽  
Khalil Baddour ◽  
Ali Mubin Aral ◽  
...  
Keyword(s):  
Animal Model ◽  
Minimally Invasive ◽  
Research University ◽  
Subglottic Stenosis ◽  
Laboratory Animals ◽  
Treatment Modalities ◽  
Source Image ◽  
Invasive Treatment ◽  
Cross Sectional ◽  
Airway Injury

Objective Develop a clinically relevant and reproducible endoscopic animal model for subglottic stenosis amenable to testing of minimally invasive therapeutic modalities. Study Design Cohort study. Setting Division of Laboratory Animals Research, University of Pittsburgh. Subjects and Methods Subglottic stenosis was induced endoscopically via microsuspension laryngoscopy in 26 New Zealand white rabbits. A trimmed polypropylene brush connected to a novel electronic stenosis induction apparatus was used to create circumferential trauma to the subglottis. By using open source image analysis software, the cross-sectional areas of the stenotic and native airways were compared to calculate the percentage of stenosis and the Myer-Cotton classification grade. Results Of the 26 rabbits, 24 (92%) exhibited stenosis after the first attempt. The mean percentage of airway stenosis was 57% (range, 34%-85%; SD, 15%). Five rabbits (19.2%) died on the day of stenosis induction from procedural complications. Of the 21 rabbits, 2 demonstrated no stenosis 7 days after initial injury and so underwent reinduction of airway injury, upon which they developed stenosis. Overall, 14 of the 21 rabbits (67%) exhibited moderate to severe stenosis (grade 2 or 3). Conclusion The stenosis induction apparatus reliably induced stenosis with a low mortality rate as compared with that of other methods in the literature. The device could be improved to generate a predetermined potentially reproducible grade of stenosis as desired by the operator. This method sets the stage for a clinically relevant and reproducible subglottic stenosis disease model that is amenable to testing of minimally invasive treatment modalities.

scholarly journals The Novel and Minimally Invasive Treatment Modalities for Female Pelvic Floor Muscle Dysfunction; Beyond the Traditional

2018 ◽  
Vol 35 (5) ◽  
pp. 358-366
Author(s):  
Yiğit Akın ◽  
Matthew Young ◽  
Muhammad Elmussareh ◽  
Nickolaus Charalampogiannis ◽  
Ali Serdar Gözen
Keyword(s):  
Minimally Invasive ◽  
Pelvic Floor ◽  
Pelvic Floor Muscle ◽  
Minimally Invasive Treatment ◽  
Treatment Modalities ◽  
Muscle Dysfunction ◽  
The Novel ◽  
Invasive Treatment ◽  
Female Pelvic Floor

CHIVA, ASVAL and related techniques – Concepts and evidence

2015 ◽  
Vol 30 (2_suppl) ◽  
pp. 42-45 ◽  
Author(s):  
Sarah Onida ◽  
Alun H Davies
Keyword(s):  
Minimally Invasive ◽  
Varicose Veins ◽  
Disease Process ◽  
Chronic Venous Disease ◽  
Treatment Modalities ◽  
Venous Disease ◽  
Invasive Treatment ◽  
Venous Circulation ◽  
Underlying Pathophysiology

Chronic venous disease (CVD) is a highly prevalent condition with significant effects on patients’ quality of life. Despite this, the underlying pathophysiology of venous disease still remains unclear. Two schools of thought exist, explaining the development and propagation of venous disease as an “ascending” and “descending” process, respectively. The descending theory, stating that CVD is secondary to proximal disease (e.g. saphenofemoral/saphenous incompetence), is the most widely accepted when planning treatment aiming to remove or destroy the junction or truncal veins. The ascending theory, describing the disease process as developing in the lower most part of the leg and propagating cranially, aims to re-route the venous circulation via minimally invasive interventions. Classically, superficial venous insufficiency has been treated with the removal of the incompetent trunk, via open surgery or, increasingly, with endovenous interventions. Minimally invasive treatment modalities aiming to preserve the saphenous trunk, such as CHIVA and ASVAL, may also play an important role in the treatment of the patient with varicose veins.

Antibiotics and Steroids in the Treatment of Acquired Subglottic Stenosis

1983 ◽  
Vol 92 (4) ◽  
pp. 377-382 ◽  
Author(s):  
John S. Supance
Keyword(s):  
Animal Model ◽  
Subglottic Stenosis ◽  
Control Group ◽  
Cross Sectional ◽  
Procaine Penicillin ◽  
Therapy Animals ◽  
Significant Difference ◽  
Medical Regimens ◽  
And Control ◽  
Systemic Antibiotics

The efficacy of a combination of systemic antibiotics and a steroid in the prevention of acquired subglottic stenosis (ASGS) was evaluated employing a previously developed canine animal model. Thirty-five healthy, postweanling mongrel puppies aged 5 weeks were each intubated for 14 days with an uncuffed polyvinyl endotracheal tube. Twenty puppies received intramuscular dexamethasone (1 mg) daily, and procaine penicillin (100,000 IU) and dihydrostreptomycin (0.125 g) in two divided doses on the day of intubation and each day thereafter until the completion of the study. The remaining 15 puppies served as a control group and received no medical therapy. Animals from both groups were killed at 5, 7, 12, 15, 20, 30, and 56 days following intubation. Comparative examinations of the laryngotracheal complexes of treated and control dogs showed that there was no significant difference between the two groups in the ultimate degree of ASGS attained, as determined by intraluminal cross-sectional area analysis, or in the extent of the lesion as documented by gross and microscopic histology. This investigation showed that the specific systemic combination of two antibiotics and a steroid used in the study was not efficacious in the prevention of ASGS in a canine animal model; for this reason we question the benefit of analogous medical regimens employed to prevent ASGS in infants and children who require long-term endotracheal intubation.

scholarly journals Decision Making in Patients With Metastatic Spine. The Role of Minimally Invasive Treatment Modalities

2019 ◽  
Vol 9 ◽  
Author(s):  
Alfredo Conti ◽  
Güliz Acker ◽  
Anne Kluge ◽  
Franziska Loebel ◽  
Anita Kreimeier ◽  
...  
Keyword(s):  
Decision Making ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Treatment Modalities ◽  
Invasive Treatment

scholarly journals New and experimental techniques in the treatment of benign prostatic diseases

2014 ◽  
Vol 61 (1) ◽  
pp. 75-80
Author(s):  
Tomislav Pejcic ◽  
Zoran Dzamic ◽  
Miodrag Acimovic ◽  
Boris Kajmakovic ◽  
Jovan Hadzi-Djokic
Keyword(s):  
Minimally Invasive ◽  
Treatment Modalities ◽  
Artery Embolization ◽  
Invasive Treatment ◽  
Urinary Tract Symptoms ◽  
High Prevalence ◽  
Prostatic Diseases ◽  
Invasive Techniques ◽  
Near Future ◽  
Lower Urinary

Background: Benign prostatic hyperplasia (BPH) and chronic prostatitis (CP) are disorders with high prevalence and have a great impact on overall morbidity in men. The patients that do not respond to medical therapy for lower urinary tract symptoms (LUTS) related to BPH are candidates for surgery. However, the number of men with BPH/LUTS seeking for non- surgical, or for less invasive treatment is growing. Aim: To present the basic information about minimally invasive treatment modalities for BPH and CP: intraprostatic injections, urethral lift procedures, modifications of transurethral microwave thermotherapy (TUMT), prostatic artery embolization etc. Conclusion: The majority of these techniques is still in experimental phase and not widely accepted. However, it is very likely that new, safe and minimally invasive techniques will appear in the near future.

scholarly journals Aesthetic Rehabilitation of Molar Incisor Hypomineralisation Using Three Minimally Invasive Treatment Modalities – A Case Report

2020 ◽  
Author(s):  
Chahita Mahesh Lalchandani ◽  
Sandeep Tandon ◽  
Tripti Sharma Rai ◽  
Rinku Mathur ◽  
Anupama Kajal
Keyword(s):  
Case Report ◽  
Minimally Invasive ◽  
Treatment Modalities ◽  
Molar Incisor Hypomineralisation ◽  
Invasive Treatment ◽  
Resin Infiltration ◽  
Current Trends ◽  
Anterior Teeth ◽  
Permanent Molars ◽  
Incisor Hypomineralisation

Brief Background Molar incisor hypomineralisation (MIH) is a common developmental condition resulting in enamel defects in first permanent molars and permanent incisors. Aesthetic treatment of patients suffering from MIH is essential to enhance their self-esteem and promote their psychological development. Current trends for treating the condition have been increasingly shifting towards minimally invasive approaches, especially considering the age of patients. The decision regarding which treatment modality to undertake for the same is complex and depends on several factors, such as the degree of severity of the enamel defect, the patient’s age, social level and expectations. Pertaining to that, the aim of this case report is to present three different aesthetic and conservative treatment approaches to anterior teeth affected by molar incisor hypomineralisation. Key Words Molar incisor hypomineralisation, aesthetic rehabilitation, minimally invasive, resin infiltration, cpp-acp.

scholarly journals Minimally invasive surgery for intra-articular calcaneus fractures: A 9-year, single-center, retrospective study of a standardized technique using a 2-point distractor

2020 ◽  
Author(s):  
Christian Rodemund ◽  
Ronny Krenn ◽  
Carl Kihm ◽  
Iris Leister ◽  
Reinhold Ortmaier ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Treatment Modalities ◽  
Wound Complications ◽  
Study Cohort ◽  
Complication Rates ◽  
Calcaneal Fractures ◽  
Invasive Treatment ◽  
Level Of Evidence ◽  
Entire Study ◽  
Operation Rate

Abstract Background: A fracture of the calcaneus can be a painful and disabling injury. Treatment modalities may be conservative or operative. Surgical treatment strategies include open reduction and internal fixation (ORIF) techniques, as well as a variety of minimally invasive methods. The aim of this study was to evaluate the treatment options and post-treatment complication rates for intra-articular calcaneal fractures at the Traumacenter Linz over a 9-year period.Methods: All patients with calcaneal fractures treated at the Traumacenter Linz between 2007 and 2015 were included in this study. The patients records were retrospectively reviewed, and the data, including demographic parameters, cause of injury, and the time between injury and operative treatment were analyzed. The number of secondary operative interventions due to soft-tissue complications, hardware removal, and the long-term arthrodesis rate were evaluated. Results: A minimally invasive 2-point-distractor method was used in 85.8% (n=182) of all operatively managed calcaneal fractures (n=212) in our department. The majority of the operations (88.7%) were performed within two days after the accident. The secondary operation rate resulting from wound complications was 2.7% in the 2-point distractor group and 16.7% in the ORIF group. A secondary arthrodesis was performed in 4.7% (n=9) of the subtalar joints in the entire study population. Conclusions:Our data supported the assumption that severe wound complications would be less likely to occur after minimally invasive treatment compared to ORIF treatment. The rate of secondary arthrodesis in the study cohort was comparable to that in the literature.Trial Registration: Not applicable, level of evidence IV.

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