scholarly journals Effects of short-term administration of .ALPHA.-chlorohydrin on reproductive toxicity parameters in male Sprague-Dawley rats.

1995 ◽  
Vol 20 (3) ◽  
pp. 195-205 ◽  
Author(s):  
Takashi YAMADA ◽  
Tadahiro INOUE ◽  
Akinori SATO ◽  
Kumiko YAMAGISHI ◽  
Motonobu SATO
Keyword(s):  
Reproductive Toxicity ◽  
Sprague Dawley ◽  
Short Term ◽  
Sprague Dawley Rats ◽  
Term Administration

Chemopreventive effect of diclofenac on mammary carcinogenesis in Sprague-Dawley rats

Biologia ◽  
2013 ◽  
Vol 68 (4) ◽  
Author(s):  
Peter Orendáš ◽  
Ivan Ahlers ◽  
Bianka Bojková ◽  
Monika Kassayová ◽  
Peter Kubatka ◽  
...  
Keyword(s):  
Tap Water ◽  
Mammary Carcinogenesis ◽  
Female Rats ◽  
Sprague Dawley ◽  
Short Term ◽  
Antiinflammatory Drugs ◽  
Sprague Dawley Rats ◽  
Term Administration ◽  
Chemopreventive Effect

AbstractChemopreventive effect of non-steroidal antiinflammatory drugs (NSAIDs) in mammary carcinogenesis was reported in several studies. In this study, the effect of a nonselective cyclooxygenase inhibitor diclofenac (DICLO) in the prevention of N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis in Sprague-Dawley female rats was evaluated. NMU was administered to animals intraperitoneally in two doses of 50 mg kg−1 b.w. within postnatal days 42-48. In experiment A (short-term administration), DICLO was administrated intramuscularly (5 mg kg−1 b.w.) every other day, starting 3 days before and for subsequent 25 days after first NMU injection. In experiment B (long-term administration), DICLO was administered in tap water (0.01 mg ml−1) continually, starting 7 days before and for subsequent 22 weeks after first NMU dose. The study was terminated 22 weeks after the first dose of NMU in both experiments. After DICLO treatment, tumor frequency per group was reduced in both variants of drug administration: in experiment A by 38% and in experiment B by 39.5%. Moreover, DICLO decreased tumor incidence by 11.5% and delayed tumor latency by 14 days in experiment B. In our preventive-curative experiments DICLO decreased some parameters of NMU-induced rat mammary carcinogenesis, mainly the tumor frequency.

Short-term administration of an aqueous extract of kalanchoe integra var. crenata (Andr.) Cuf leaves produces no major organ damage in Sprague-Dawley rats

2014 ◽  
Vol 151 (2) ◽  
pp. 891-896 ◽  
Author(s):  
Isaac J. Asiedu-Gyekye ◽  
Daniel A. Antwi ◽  
Charles Awortwe ◽  
Benoit Banga N'guessan ◽  
Alexander K. Nyarko
Keyword(s):  
Aqueous Extract ◽  
Organ Damage ◽  
Sprague Dawley ◽  
Short Term ◽  
Sprague Dawley Rats ◽  
Major Organ ◽  
Term Administration

scholarly journals Effect of a Short-Term and Long-Term Melatonin Administration on Mammary Carcinogenesis in Female Sprague-Dawley Rats Influenced by Repeated Psychoemotional Stress

2007 ◽  
Vol 76 (3) ◽  
pp. 371-377 ◽  
Author(s):  
M. Kassayová ◽  
E. Adámeková ◽  
B. Bojková ◽  
P. Kubatka ◽  
I. Ahlers ◽  
...  
Keyword(s):  
Mammary Carcinogenesis ◽  
Tumour Volume ◽  
Female Rats ◽  
Sprague Dawley ◽  
Short Term ◽  
Psychoemotional Stress ◽  
Sprague Dawley Rats ◽  
Melatonin Administration ◽  
Term Administration

The aim of this study was to evaluate the effect of melatonin (MEL) on N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis in female Sprague-Dawley rats exposed to repeated psychoemotional stress - immobilization in boxes. NMU was applied intraperitoneally in two doses each of 50 mg/kg b.w. between 40 - 50 postnatal days. Melatonin was administered in drinking water at a concentration of 4 μg/ml daily from 15:00 h to 8:00 h. The application was initiated 5 days prior to the fi rst NMU dose and lasted 15 days, i.e. during the promotion phase of tumour development, or long-term until the end of the experiment (week 20). Immobilization (2 h per day) began on the third day after the second carcinogen application and lasted for 7 consecutive days. Short-term MEL administration to immobilized animals increased incidence by 22%, decreased tumour frequency per animal by 26% and reduced tumour volume gain (by 21%) when compared to the immobilized group without MEL application. Decreased frequency per animal by 28% and more than a 40% decrease in tumour volume gain and cumulative volume were the most pronounced changes in the animals drinking MEL until the end of the experiment. Long-term MEL administration reduced the number and size of mammary tumours more markedly than its short-term administration. Melatonin decreased certain attributes of mammary carcinogenesis in female rats influenced by psychoemotional stress.

scholarly journals Short-Term High Fat Intake Does Not Significantly Alter Markers of Renal Function or Inflammation in Young Male Sprague-Dawley Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Catherine Crinigan ◽  
Matthew Calhoun ◽  
Karen L. Sweazea
Keyword(s):  
Kidney Disease ◽  
Renal Mass ◽  
Early Stage ◽  
Young Male ◽  
Protective Effects ◽  
Sprague Dawley ◽  
High Fat ◽  
Short Term ◽  
Sprague Dawley Rats ◽  
The Impact

Chronic high fat feeding is correlated with diabetes and kidney disease. However, the impact of short-term high fat diets (HFD) is not well-understood. Six weeks of HFD result in indices of metabolic syndrome (increased adiposity, hyperglycemia, hyperinsulinemia, hyperlipidemia, hyperleptinemia, and impaired endothelium-dependent vasodilation) compared to rats fed on standard chow. The hypothesis was that short-term HFD would induce early signs of renal disease. Young male Sprague-Dawley rats were fed either HFD (60% fat) or standard chow (5% fat) for six weeks. Morphology was determined by measuring changes in renal mass and microstructure. Kidney function was measured by analyzing urinary protein, creatinine, and hydrogen peroxide (H2O2) concentrations, as well as plasma cystatin C concentrations. Renal damage was measured through assessment of urinary oxDNA/RNA concentrations as well as renal lipid peroxidation, tumor necrosis factor alpha (TNFα), and interleukin 6 (IL-6). Despite HFD significantly increasing adiposity and renal mass, there was no evidence of early stage kidney disease as measured by changes in urinary and plasma biomarkers as well as histology. These findings suggest that moderate hyperglycemia and inflammation produced by short-term HFD are not sufficient to damage kidneys or that the ketogenic HFD may have protective effects within the kidneys.

scholarly journals Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet

2020 ◽  
Vol Volume 13 ◽  
pp. 111-124
Author(s):  
Dragana Komnenov ◽  
Peter E Levanovich ◽  
Natalia Perecki ◽  
Charles S Chung ◽  
Noreen F Rossi
Keyword(s):  
Diastolic Dysfunction ◽  
Aortic Stiffness ◽  
High Salt ◽  
Sprague Dawley ◽  
Short Term ◽  
High Salt Diet ◽  
Salt Diet ◽  
Sprague Dawley Rats

The reproductive toxicity of organic compounds extracted from drinking water sources on Sprague Dawley rats: An in vitro study

2009 ◽  
Vol 25 (3) ◽  
pp. 284-293 ◽  
Author(s):  
Jiang Wu ◽  
Guanjiu Hu ◽  
Xiaoyi Wang ◽  
Dongmei Li ◽  
Hongxia Yu ◽  
...  
Keyword(s):  
Drinking Water ◽  
Organic Compounds ◽  
Reproductive Toxicity ◽  
In Vitro Study ◽  
Water Sources ◽  
Vitro Study ◽  
Sprague Dawley ◽  
Drinking Water Sources ◽  
Sprague Dawley Rats

scholarly journals Early Occurrence of Spontaneous Tumors in CD-1 Mice and Sprague—Dawley Rats

2004 ◽  
Vol 32 (4) ◽  
pp. 371-374 ◽  
Author(s):  
Woo-Chan Son ◽  
Chirukandath Gopinath
Keyword(s):  
Life Sciences ◽  
Male Rats ◽  
Sprague Dawley ◽  
Control Groups ◽  
Oral Gavage ◽  
Short Term ◽  
Young Control ◽  
Sprague Dawley Rats ◽  
Early Occurrence ◽  
General Profile

It is sometimes difficult to assess the relevance of tumors that occur in treated animals in short-term studies. This report is intended to establish a general profile of tumor occurrence in young control CD-1 mice and Sprague—Dawley rats. Data from 20 rat and 20 mouse carcinogenicity studies conducted between 1990 and 2002 at Huntingdon Life Sciences, UK, were collected and evaluated. The route of administration was either dietary or oral gavage, and the analysis was confined to sporadic deaths (decedents) in control groups occurring during the first 50 weeks of study. In addition, tumor occurrence between 50—80 weeks were compared. In mice, the most common tumor was lymphoma, followed by bronchiolo-alveolar adenoma. In rats, the most common tumor was adenoma of the pituitary gland, followed by mammary fibroadenoma, and adenocarcinoma. When studies of up to 50 weeks, between 50 and 80 weeks, and at 2-year termination were compared, there was no great difference in tumor occurrence except in male rats, in which the most common tumor up to 50 weeks on study was lymphoma, whereas the most common tumor between 50—80 weeks and at 2 years was pituitary adenoma.

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