Traditionally teacher's profession is associated with high levels of burnout. However the scope of the study is to differentiate the role of personality in experiencing burnout. In this paper is presented the exploration of the relationship between teacher's burnout syndrome, some personality traits and locus of control. The sample comprised of 120 teachers distributed by gender as follow 76.6% (N=92) women and 23.3% (N=28) men. To investigate the relationship between the personality characteristics (extraversion-introversion, neuroticism, psychoticism, and loci of control) and the levels of burnout syndrome dimensions (emotional exhaustion, depersonalization, and reduced personal accomplishment) a Spearmen correlation analysis was performed. To determine which one of all personality characteristics would have the most significant influence on the burnout syndrome dimensions data were verified with eta squared coefficient. As predicted by the research suggestions the study's results showed significant correlations between teacher's burnout syndrome and personality traits - intro/extraversion, neuroticism, psychoticism, and locus of control. It has been revealed that neuroticism and intro/extroversion have the greatest effect on all three burnout dimensions (emotional exhaustion, depersonalization, and reduced personal achievements). Localization of control as variable predicting burnout showed a moderate effect on two out of three factors (emotional exhaustion and reduced personal achievements). With the lowest effect influencing, only emotional exhaustion was found to be psychoticism. Keywords: burnout syndrome, teacher's occupational stress, personality traits, locus of control.