Effective Use of Microdosing and Positron Emission Tomography (PET) Studies on New Drug Discovery and Development

2009 ◽  
Vol 24 (2) ◽  
pp. 127-129 ◽  
Author(s):  
Yuichi Sugiyama
Keyword(s):  
Positron Emission Tomography ◽  
Drug Discovery ◽  
Emission Tomography ◽  
Drug Discovery And Development ◽  
New Drug ◽  
Positron Emission ◽  
Effective Use

Robustness of Anatomically Guided Pixel-by-Pixel Algorithms for Partial Volume Effect Correction in Positron Emission Tomography

1999 ◽  
Vol 19 (5) ◽  
pp. 547-559 ◽  
Author(s):  
Daniel Strul ◽  
Bernard Bendriem
Keyword(s):  
Positron Emission Tomography ◽  
Real Data ◽  
Volume Effect ◽  
Performance Criterion ◽  
Three Dimensions ◽  
Emission Tomography ◽  
Tissue Segmentation ◽  
Positron Emission ◽  
Current Article ◽  
Effective Use

Several algorithms have been proposed to improve positron emission tomography quantification by combining anatomical and functional information in a pixel-by-pixel correction scheme. The precision of these methods when applied to real data depends on the precision of the manifold correction steps, such as full-width half-maximum modeling, magnetic resonance imaging-positron emission tomography registration, tissue segmentation, or background activity estimation. A good understanding of the influence of these parameters thus is critical to the effective use of the algorithms. In the current article, the authors present a monodimensional model that allows a simple theoretical and experimental evaluation of correction imprecision. The authors then assess correction robustness in three dimensions with computer simulations, and evaluate the validity of regional SD as a correction performance criterion.

scholarly journals Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2191
Author(s):  
Segundo Francisco García-Argüello ◽  
Beatriz Lopez-Lorenzo ◽  
Bart Cornelissen ◽  
Graham Smith
Keyword(s):  
Positron Emission Tomography ◽  
Drug Discovery ◽  
Patient Management ◽  
Development Process ◽  
Caspase 3 ◽  
Emission Tomography ◽  
Structural Proteins ◽  
Positron Emission ◽  
Induced Apoptosis

Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is activation of the “executioner” caspase-3 enzyme to commence cleavage of key structural proteins. One strategy to measure caspase-3 activity is Positron Emission Tomography using isatin-5-sulfonamide radiotracers. One such radiotracer is [18F]ICMT-11, which has progressed to clinical application. This review summarises the design and development process for [18F]ICMT-11, suggesting potential avenues for further innovation.

Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

2014 ◽  
Vol 57 (22) ◽  
pp. 9232-9258 ◽  
Author(s):  
Markus Piel ◽  
Ingo Vernaleken ◽  
Frank Rösch
Keyword(s):  
Positron Emission Tomography ◽  
Drug Discovery ◽  
Drug Monitoring ◽  
Emission Tomography ◽  
Positron Emission

Positron emission tomography neuroreceptor imaging as a tool in drug discovery, research and development

1999 ◽  
Vol 3 (4) ◽  
pp. 388-394 ◽  
Author(s):  
H Donald Burns ◽  
Terence G Hamill ◽  
Wai-si Eng ◽  
Barbara Francis ◽  
Christine Fioravanti ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Drug Discovery ◽  
Research And Development ◽  
Emission Tomography ◽  
Discovery Research ◽  
Positron Emission ◽  
Drug Discovery Research ◽  
Neuroreceptor Imaging
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