Cell Size Regulation Through Tunable Geometric Localization of the Bacterial Actin Cytoskeleton

2018 ◽  
Author(s):  
Alexandre Colavin ◽  
Handuo Shi ◽  
Kerwyn Casey Huang
Keyword(s):  
Actin Cytoskeleton ◽  
Cell Size ◽  
Size Regulation ◽  
Geometric Localization

Cell cycle and cell size regulation in Down Syndrome cells

2003 ◽  
pp. 51-58 ◽  
Author(s):  
M. Rosner ◽  
A. Kowalska ◽  
A. Freilinger ◽  
A-R. Prusa ◽  
E. Marton ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Down Syndrome ◽  
Cell Size ◽  
Size Regulation

scholarly journals Cell Size Regulation in Bacteria

2014 ◽  
Vol 112 (20) ◽  
Author(s):  
Ariel Amir
Keyword(s):  
Cell Size ◽  
Size Regulation

Rho GTPase signaling modulates cell shape and contractile phenotype in an isoactin-specific manner

2003 ◽  
Vol 285 (5) ◽  
pp. C1116-C1121 ◽  
Author(s):  
Alexey Y. Kolyada ◽  
Kathleen N. Riley ◽  
Ira M. Herman
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Actin Cytoskeleton ◽  
Cell Size ◽  
Rho Gtpase ◽  
Small Gtpases ◽  
Protein Isoforms ◽  
Stress Fibers ◽  
Contractile Phenotype ◽  
Specific Manner

Rho family small GTPases (Rho, Rac, and Cdc42) play an important role in cell motility, adhesion, and cell division by signaling reorganization of the actin cytoskeleton. Here, we report an isoactin-specific, Rho GTPase-dependent signaling cascade in cells simultaneously expressing smooth muscle and nonmuscle actin isoforms. We transfected primary cultures of microvascular pericytes, cells related to vascular smooth muscle cells, with various Rho-related and Rho-specific expression plasmids. Overexpression of dominant positive Rho resulted in the formation of nonmuscle actin-containing stress fibers. At the same time, α-vascular smooth muscle actin (αVSMactin) containing stress fibers were disassembled, resulting in a dramatic reduction in cell size. Rho activation also yielded a disassembly of smooth muscle myosin and nonmuscle myosin from stress fibers. Overexpression of wild-type Rho had similar but less dramatic effects. In contrast, dominant negative Rho and C3 exotransferase or dominant positive Rac and Cdc42 expression failed to alter the actin cytoskeleton in an isoform-specific manner. The loss of smooth muscle contractile protein isoforms in pericyte stress fibers, together with a concomitant decrease in cell size, suggests that Rho activation influences “contractile” phenotype in an isoactin-specific manner. This, in turn, should yield significant alteration in microvascular remodeling during developmental and pathologic angiogenesis.

scholarly journals A simple molecular mechanism explains multiple patterns of cell-size regulation

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182633 ◽  
Author(s):  
Morgan Delarue ◽  
Daniel Weissman ◽  
Oskar Hallatschek
Keyword(s):  
Cell Size ◽  
Molecular Mechanism ◽  
Size Regulation

scholarly journals A Mechanism for Cell Size Regulation by the Insulin and Insulin-Like Growth Factor-I Receptors

2006 ◽  
Vol 66 (23) ◽  
pp. 11106-11109 ◽  
Author(s):  
Hongzhi Sun ◽  
Xiao Tu ◽  
Renato Baserga
Keyword(s):  
Growth Factor ◽  
Cell Size ◽  
Insulin Like Growth Factor ◽  
Size Regulation ◽  
Factor I ◽  
Growth Factor I

A model of cell size regulation

1965 ◽  
Vol 9 (3) ◽  
pp. 444-470 ◽  
Author(s):  
M. Yǎs ◽  
M. Sugita ◽  
Arlene Bensam
Keyword(s):  
Cell Size ◽  
Size Regulation

scholarly journals Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation

2011 ◽  
Vol 360 (1) ◽  
pp. 66-76 ◽  
Author(s):  
Nicolas F. Berbari ◽  
Nicholas W. Kin ◽  
Neeraj Sharma ◽  
Edward J. Michaud ◽  
Robert A. Kesterson ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Cell Size ◽  
Size Regulation ◽  
Altered Cell

Divergent function of polycystin 1 and polycystin 2 in cell size regulation

2020 ◽  
Vol 521 (2) ◽  
pp. 290-295 ◽  
Author(s):  
Amandine Viau ◽  
Fruzsina Kotsis ◽  
Christopher Boehlke ◽  
Simone Braeg ◽  
Marinella Klein ◽  
...  
Keyword(s):  
Cell Size ◽  
Size Regulation

scholarly journals Actin-dependent vacuolar occupancy of the cell determines auxin-induced growth repression

2015 ◽  
Vol 113 (2) ◽  
pp. 452-457 ◽  
Author(s):  
David Scheuring ◽  
Christian Löfke ◽  
Falco Krüger ◽  
Maike Kittelmann ◽  
Ahmed Eisa ◽  
...  
Keyword(s):  
Actin Cytoskeleton ◽  
Cell Size ◽  
Negative Influence ◽  
Cellular Growth ◽  
Dependent Manner ◽  
Animal Cells ◽  
Cellular Life ◽  
Resolution Imaging ◽  
Genetic Interference ◽  
Main Components

The cytoskeleton is an early attribute of cellular life, and its main components are composed of conserved proteins. The actin cytoskeleton has a direct impact on the control of cell size in animal cells, but its mechanistic contribution to cellular growth in plants remains largely elusive. Here, we reveal a role of actin in regulating cell size in plants. The actin cytoskeleton shows proximity to vacuoles, and the phytohormone auxin not only controls the organization of actin filaments but also impacts vacuolar morphogenesis in an actin-dependent manner. Pharmacological and genetic interference with the actin–myosin system abolishes the effect of auxin on vacuoles and thus disrupts its negative influence on cellular growth. SEM-based 3D nanometer-resolution imaging of the vacuoles revealed that auxin controls the constriction and luminal size of the vacuole. We show that this actin-dependent mechanism controls the relative vacuolar occupancy of the cell, thus suggesting an unanticipated mechanism for cytosol homeostasis during cellular growth.

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