Autologous Transplantation of Photoactivated Subcutaneous Adipose Tissue Improves Glucose Homeostasis in High-Fat Diet-Induced Obese Mice

2018 ◽  
Author(s):  
Rong Li ◽  
Kai Li ◽  
Liping Zhang ◽  
Lin Wang ◽  
Ni Chen ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Homeostasis ◽  
High Fat Diet ◽  
Subcutaneous Adipose Tissue ◽  
Autologous Transplantation ◽  
Obese Mice ◽  
High Fat ◽  
Subcutaneous Adipose

Sex differences in subcutaneous adipose tissue redox homeostasis and inflammation markers in control and high-fat diet fed rats

2019 ◽  
Vol 44 (7) ◽  
pp. 720-726 ◽  
Author(s):  
Renata Prado Vasconcelos ◽  
Milena Simões Peixoto ◽  
Keciany Alves de Oliveira ◽  
Andrea Claudia Freitas Ferreira ◽  
Andrelina Noronha Coelho-de-Souza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Subcutaneous Adipose Tissue ◽  
Redox Homeostasis ◽  
Female Rats ◽  
Mrna Levels ◽  
High Fat ◽  
Tnf Α ◽  
Subcutaneous Adipose

The development of obesity-related metabolic disorders is more evident in male in comparison with female subjects, but the mechanisms are unknown. Several studies have shown that oxidative stress is involved in the pathophysiology of obesity, but the majority of these studies were performed with male animals. The aim of this study was to evaluate the sex-related differences in subcutaneous adipose tissue redox homeostasis and inflammation of rats chronically fed a high-fat diet. NADPH oxidase (NOX), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase activities were evaluated in the subcutaneous adipose tissue (SC) of adult male and female rats fed either a standard chow (SCD) or a high-fat diet (HFD) for 11 weeks. NOX2 and NOX4 messenger RNA (mRNA) levels, total reduced thiols, interleukin (IL)-1β, tumor necrosis factor α (TNF-α), and IL-6 were also determined. Higher antioxidant enzyme activities and total reduced thiol levels were detected in SC of control male compared with female rats. Chronic HFD administration increased NOX activity and NOX2 and NOX4 mRNA levels and decreased SOD and GPx activities only in male animals. IL-1β, TNF-α, and IL-6 levels, as well as Adgre1, CD11b, and CD68 mRNA levels, were also higher in SC of males after HFD feeding. In SC of females, catalase activity was higher after HFD feeding. Taken together, our results show that redox homeostasis and inflammation of SC is sexually dimorphic. Furthermore, males show higher oxidative stress in SC after 11 weeks of HFD feeding owing to both increased reactive oxygen species (ROS) production through NOX2 and NOX4 and decreased ROS detoxification.

scholarly journals Curcuma longa Extract Associated with White Pepper Lessens High Fat Diet-Induced Inflammation in Subcutaneous Adipose Tissue

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e81252 ◽  
Author(s):  
Audrey M. Neyrinck ◽  
Maud Alligier ◽  
Patrick B. Memvanga ◽  
Elodie Névraumont ◽  
Yvan Larondelle ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Subcutaneous Adipose Tissue ◽  
Curcuma Longa ◽  
High Fat ◽  
White Pepper ◽  
Subcutaneous Adipose

Inhibition of Adipose Tissue Angiogenesis Prevents Rebound Weight Regain after Calorie Restriction Independent of Hypothalamic Melanocortin System in Obese Mice Fed a High-Fat Diet

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 287-LB
Author(s):  
HYE-JIN LEE ◽  
MUN-GYU SONG ◽  
NA-HEE HA ◽  
BO-YEONG JIN ◽  
SANG-HYUN CHOI ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Calorie Restriction ◽  
High Fat Diet ◽  
Weight Regain ◽  
Obese Mice ◽  
High Fat ◽  
Melanocortin System

Soyasaponins Reduce Inflammation and Improve Serum Lipid Profiles and Glucose Homeostasis in High Fat Diet-Induced Obese Mice

2018 ◽  
Vol 62 (19) ◽  
pp. 1800205 ◽  
Author(s):  
Qunying Xie ◽  
Xiangfu Gu ◽  
Junbin Chen ◽  
Minshun Liu ◽  
Fei Xiong ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
Obese Mice ◽  
High Fat

PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice

2021 ◽  
Vol 218 (9) ◽  
Author(s):  
Yu-Wen Cheng ◽  
Ze-Bei Zhang ◽  
Bei-Di Lan ◽  
Jing-Rong Lin ◽  
Xiao-Hui Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Cardiac Remodeling ◽  
High Fat Diet ◽  
Platelet Derived Growth Factor ◽  
Obese Mice ◽  
Mechanistic Studies ◽  
High Fat ◽  
Cardiac Damage ◽  
First Time

Obesity-induced secretory disorder of adipose tissue–derived factors is important for cardiac damage. However, whether platelet-derived growth factor-D (PDGF-D), a newly identified adipokine, regulates cardiac remodeling in angiotensin II (AngII)–infused obese mice is unclear. Here, we found obesity induced PDGF-D expression in adipose tissue as well as more severe cardiac remodeling compared with control lean mice after AngII infusion. Adipocyte-specific PDGF-D knockout attenuated hypertensive cardiac remodeling in obese mice. Consistently, adipocyte-specific PDGF-D overexpression transgenic mice (PA-Tg) showed exacerbated cardiac remodeling after AngII infusion without high-fat diet treatment. Mechanistic studies indicated that AngII-stimulated macrophages produce urokinase plasminogen activator (uPA) that activates PDGF-D by splicing full-length PDGF-D into the active PDGF-DD. Moreover, bone marrow–specific uPA knockdown decreased active PDGF-DD levels in the heart and improved cardiac remodeling in HFD hypertensive mice. Together, our data provide for the first time a new interaction pattern between macrophage and adipocyte: that macrophage-derived uPA activates adipocyte-secreted PDGF-D, which finally accelerates AngII-induced cardiac remodeling in obese mice.

scholarly journals Increasing Dietary Fish Oil Reduces Adiposity and Mitigates Bone Deterioration in Growing C57BL/6 Mice Fed a High-Fat Diet

2019 ◽  
Vol 150 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Jay J Cao ◽  
Brian R Gregoire ◽  
Kim G Michelsen ◽  
Matthew J Picklo
Keyword(s):  
Adipose Tissue ◽  
Bone Mass ◽  
Fish Oil ◽  
High Fat Diet ◽  
Bone Structure ◽  
Tartrate Resistant Acid Phosphatase ◽  
Serum Concentrations ◽  
Obese Mice ◽  
High Fat ◽  
Long Chain

ABSTRACT Background Intake of total fat is linked to obesity and inversely associated with bone density in humans. Epidemiologic and animal studies show that long-chain n–3 (ω-3) PUFAs supplied as fish oil (FO) are beneficial to skeletal health. Objective This study tested the hypothesis that increasing dietary FO would decrease adiposity and improve bone-related outcomes in growing obese mice. Methods Male C57BL/6 mice at 6 wk old were assigned to 6 treatment groups and fed either a normal-fat diet (3.85 kcal/g and 10% energy as fat) or a high-fat diet (HF; 4.73 kcal/g and 45% energy as fat) containing either 0%, 3%, or 9% energy as FO (0FO, 3FO, and 9FO, respectively) ad libitum for 6 mo. Bone structure, body composition, and serum bone-related cytokines were measured. Results The HF diet increased the expression of the adipose tissue tumor necrosis factor α (Tnfa) and serum concentrations of leptin and tartrate-resistant acid phosphatase (TRAP), and decreased serum concentrations of osteocalcin and bone-specific alkaline phosphatase (P < 0.05). FO decreased fat mass (P < 0.05), serum TRAP (P < 0.05), and adipose tissue Tnfa expression (P < 0.01). Bone content of long-chain n–3 PUFAs was increased and n–6 PUFAs were decreased with the elevation in dietary FO content (P < 0.01). Compared with mice fed 9FO, animals fed 3FO had higher femoral bone volume/total volume (25%), trabecular number (23%), connectivity density (82%), and bone mass of second lumbar vertebrae (12%) and lower femoral trabecular separation (−19%). Mice fed the 3FO HF diet had 42% higher bone mass than those fed the 0FO HF diet. Conclusions These data indicate increasing dietary FO ≤3% energy can decrease adiposity and mitigate HF diet–induced bone deterioration in growing C57BL/6 mice possibly by reducing inflammation and bone resorption. FO at 9% diet energy had no further beneficial effects on bone of obese mice.

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