scholarly journals Curcuma longa Extract Associated with White Pepper Lessens High Fat Diet-Induced Inflammation in Subcutaneous Adipose Tissue

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e81252 ◽  
Author(s):  
Audrey M. Neyrinck ◽  
Maud Alligier ◽  
Patrick B. Memvanga ◽  
Elodie Névraumont ◽  
Yvan Larondelle ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Subcutaneous Adipose Tissue ◽  
Curcuma Longa ◽  
High Fat ◽  
White Pepper ◽  
Subcutaneous Adipose

Sex differences in subcutaneous adipose tissue redox homeostasis and inflammation markers in control and high-fat diet fed rats

2019 ◽  
Vol 44 (7) ◽  
pp. 720-726 ◽  
Author(s):  
Renata Prado Vasconcelos ◽  
Milena Simões Peixoto ◽  
Keciany Alves de Oliveira ◽  
Andrea Claudia Freitas Ferreira ◽  
Andrelina Noronha Coelho-de-Souza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Subcutaneous Adipose Tissue ◽  
Redox Homeostasis ◽  
Female Rats ◽  
Mrna Levels ◽  
High Fat ◽  
Tnf Α ◽  
Subcutaneous Adipose

The development of obesity-related metabolic disorders is more evident in male in comparison with female subjects, but the mechanisms are unknown. Several studies have shown that oxidative stress is involved in the pathophysiology of obesity, but the majority of these studies were performed with male animals. The aim of this study was to evaluate the sex-related differences in subcutaneous adipose tissue redox homeostasis and inflammation of rats chronically fed a high-fat diet. NADPH oxidase (NOX), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase activities were evaluated in the subcutaneous adipose tissue (SC) of adult male and female rats fed either a standard chow (SCD) or a high-fat diet (HFD) for 11 weeks. NOX2 and NOX4 messenger RNA (mRNA) levels, total reduced thiols, interleukin (IL)-1β, tumor necrosis factor α (TNF-α), and IL-6 were also determined. Higher antioxidant enzyme activities and total reduced thiol levels were detected in SC of control male compared with female rats. Chronic HFD administration increased NOX activity and NOX2 and NOX4 mRNA levels and decreased SOD and GPx activities only in male animals. IL-1β, TNF-α, and IL-6 levels, as well as Adgre1, CD11b, and CD68 mRNA levels, were also higher in SC of males after HFD feeding. In SC of females, catalase activity was higher after HFD feeding. Taken together, our results show that redox homeostasis and inflammation of SC is sexually dimorphic. Furthermore, males show higher oxidative stress in SC after 11 weeks of HFD feeding owing to both increased reactive oxygen species (ROS) production through NOX2 and NOX4 and decreased ROS detoxification.

PPARGC1A DNA methylation in subcutaneous adipose tissue in low birth weight subjects — impact of 5days of high-fat overfeeding

Metabolism ◽  
2014 ◽  
Vol 63 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Linn Gillberg ◽  
Stine C. Jacobsen ◽  
Tina Rönn ◽  
Charlotte Brøns ◽  
Allan Vaag
Keyword(s):  
Dna Methylation ◽  
Adipose Tissue ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Subcutaneous Adipose Tissue ◽  
High Fat ◽  
Subcutaneous Adipose

scholarly journals Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice

2017 ◽  
Vol 233 (3) ◽  
pp. 269-279 ◽  
Author(s):  
Greg M Kowalski ◽  
Michael J Kraakman ◽  
Shaun A Mason ◽  
Andrew J Murphy ◽  
Clinton R Bruce
Keyword(s):  
Adipose Tissue ◽  
Glucose Tolerance ◽  
Glucose Intolerance ◽  
Subcutaneous Adipose Tissue ◽  
Glucose Disposal ◽  
Oral Glucose ◽  
High Fat ◽  
Subcutaneous Adipose ◽  
High Sucrose

The high-fat, high-sucrose diet (HFSD)–fed C57Bl/6 mouse is a widely used model of prediabetes. However, studies typically implement a relatively short dietary intervention lasting between 4 and 16 weeks; as a result, little is known about how a long-term HFSD influences the metabolic profile of these mice. Therefore, the aim of this investigation was to examine the effects of consuming a HFSD for 42 weeks on the development of hyperinsulinaemia and glucose intolerance in male C57Bl/6 mice. Two cohorts of HFSD mice were studied at independent institutes and they underwent an oral glucose tolerance test (OGTT) with measures of plasma insulin and free fatty acids (FFA). Age-matched chow-fed control mice were also studied. The HFSD-fed mice were hyperinsulinaemic and grossly obese, being over 25 g heavier than chow-fed mice, which was due to a marked expansion of subcutaneous adipose tissue. This was associated with a 3-fold increase in liver lipid content. Glucose tolerance, however, was either the same or better than control mice due to the preservation of glucose disposal as revealed by a dynamic stable isotope-labelled OGTT. In addition, plasma FFAs were suppressed to lower levels in HFSD mice during the OGTT. In conclusion, we have made the paradoxical observation that long-term HFSD feeding results in the resolution of glucose intolerance in the C57Bl/6 mouse. Mechanistically, we propose that the gross expansion of subcutaneous adipose tissue increases the glucose disposal capacity of the HFSD-fed mouse, which overcomes the prevailing insulin resistance to improve glucose tolerance.

Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production

2001 ◽  
Vol 100 (5) ◽  
pp. 493-498 ◽  
Author(s):  
Kevin EVANS ◽  
Mo L. CLARK ◽  
Keith N. FRAYN
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
The Other ◽  
High Fat ◽  
Mixed Meal ◽  
Blood Samples ◽  
Plasma Leptin ◽  
Subcutaneous Adipose ◽  
Tomato Soup ◽  
Venous Plasma

Leptin is secreted by adipocytes and plays a role in the regulation of food intake. However, the regulation of leptin production by adipose tissue is unclear. We have investigated whether a mixed meal or a high-fat load given orally, or a pure fat load given intravenously, stimulates adipose tissue leptin production. Six volunteers were studied on two occasions following an overnight fast. On one occasion they consumed tomato soup containing 40 g of triacylglycerol (as Intralipid) and 9.6 g of carbohydrate; on the other occasion Intralipid was infused intravenously over 4 h to give the same fat load. A further eight subjects consumed a mixed meal (containing 37 g of fat and 100 g of carbohydrate) after an overnight fast. Paired blood samples were obtained from an arterialized hand vein and a vein draining subcutaneous adipose tissue at baseline and for 6 h following the meals or the start of the infusion. After both the intravenous and oral fat loads, the arterialized and adipose venous plasma leptin concentrations decreased over 6 h (both P< 0.001), as did the leptin veno–arterial difference (P = 0.01). Following the mixed meal, there was a slight increase in the arterialized plasma leptin concentration (P = 0.02) and a more marked increase in the adipose venous plasma leptin concentration (P = 0.03) and in the adipose tissue leptin veno–arterial difference (P = 0.01), all peaking at 240 min. We conclude that the increase in plasma leptin concentration observed after meals is not simply a result of an energy load, but is in response to a signal that is not present following a fat load without carbohydrate.

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