Plasma Concentration of Isoniazid and Single-Nucleotide Polymorphisms of N-Acetyltransferase 2 Predict Risk of Systemic Drug Reactions During Weekly Rifapentine and Isoniazid Therapy for Latent Tuberculosis Infection: A Prospective Observational Cohort Study

2018 ◽  
Author(s):  
Meng-Rui Lee ◽  
Hung-Ling Huang ◽  
Shu-Wen Lin ◽  
Ya-Ting Lin ◽  
So-Yi Chang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Nucleotide Polymorphisms ◽  
Drug Reactions ◽  
Single Nucleotide ◽  
Observational Cohort ◽  
Systemic Drug

scholarly journals Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children – a prospective observational cohort study of 6,601 admissions

BMC Medicine ◽  
2013 ◽  
Vol 11 (1) ◽  
Author(s):  
Signe Thiesen ◽  
Elizabeth J Conroy ◽  
Jennifer R Bellis ◽  
Louise E Bracken ◽  
Helena L Mannix ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Adverse Drug Reactions ◽  
Observational Cohort Study ◽  
Hospitalized Children ◽  
Prospective Observational Cohort Study ◽  
Drug Reactions ◽  
Observational Cohort

scholarly journals Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil

2021 ◽  
Author(s):  
Allyson G. Costa ◽  
Brenda K. S. Carvalho ◽  
Mariana Araújo-Pereira ◽  
Hiochelson N. S. Ibiapina ◽  
Renata Spener-Gomes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Large Scale ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Observational Cohort Study ◽  
Lessons Learned ◽  
Interferon Gamma Release Assay ◽  
Systematic Screening ◽  
Observational Cohort ◽  
Release Assay

The IGRA has emerged as a useful tool for identifying persons with LTBI. Although the implementation of IGRAs is of utmost importance, to our knowledge there is scarce information on the identification of logistical and technical challenges for systematic screening for LTBI on a large scale.

Comparison of three tests for latent tuberculosis infection in high-risk people in the USA: an observational cohort study

2021 ◽  
Author(s):  
Christine S Ho ◽  
Pei-Jean I Feng ◽  
Masahiro Narita ◽  
Jason E Stout ◽  
Michael Chen ◽  
...  
Keyword(s):  
Cohort Study ◽  
High Risk ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Observational Cohort Study ◽  
Tuberculosis Infection ◽  
The Usa ◽  
Observational Cohort

scholarly journals Association of Drug Metabolic Enzyme Genetic Polymorphisms and Adverse Drug Reactions in Patients Receiving Rifapentine and Isoniazid Therapy for Latent Tuberculosis

2019 ◽  
Vol 17 (1) ◽  
pp. 210 ◽  
Author(s):  
Ya-Yen Yu ◽  
Shih-Ming Tsao ◽  
Wen-Ta Yang ◽  
Wei-Chang Huang ◽  
Ching-Hsiung Lin ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Genetic Polymorphisms ◽  
Adverse Drug Reactions ◽  
Odds Ratio ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Metabolic Enzyme ◽  
Nucleotide Polymorphisms ◽  
Drug Reactions ◽  
Single Nucleotide

Weekly rifapentine and isoniazid therapy (3HP) is the most frequent treatment for latent tuberculosis infection (LTBI). However, the association between major adverse drug reactions (ADRs) and drug metabolic enzyme single-nucleotide polymorphisms (SNPs) remains unclear. In this study, 377 participants who received the 3HP regimen were recruited and examined for genotyping of CYP5A6, CYP2B6, CYP2C19, CYP2E1, and NAT2 SNPs. In our study, 184 participants (48.4%) developed ADRs. Moreover, CYP2C19 rs4986893 (TT vs. CC+CT, odds ratio [OR] [95% CI]: 2.231 [1.015–4.906]), CYP2E1 rs2070676 (CC vs. CG+GG, OR [95% CI]: 1.563 [1.022–2.389]), and CYP2E1 rs2515641 (CC vs. CT+TT, OR [95% CI]: 1.903 [1.250–2.898]) were associated with ADR development. In conclusion, CYP2C19 and CYP2E1 SNPs may provide useful information regarding ADRs in LTBI patients receiving the 3HP regimen.

Neurological Outcome and Quality of Life Three Months after COVID-19: A Prospective Observational Cohort Study

2020 ◽  
Author(s):  
Verena Rass ◽  
Ronny Beer ◽  
Alois Josef Schiefecker ◽  
Mario Kofler ◽  
Anna Lindner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Neurological Outcome ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort
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