Adverse drug reactions and deliberate self-poisoning as cause of admission to the intensive care unit: a 1-year prospective observational cohort study

2008 ◽  
Vol 35 (2) ◽  
pp. 266-274 ◽  
Author(s):  
Lukas Schwake ◽  
Ines Wollenschläger ◽  
Wolfgang Stremmel ◽  
Jens Encke
Keyword(s):  
Intensive Care Unit ◽  
Cohort Study ◽  
Intensive Care ◽  
Adverse Drug Reactions ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Drug Reactions ◽  
Observational Cohort

scholarly journals Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children – a prospective observational cohort study of 6,601 admissions

BMC Medicine ◽  
2013 ◽  
Vol 11 (1) ◽  
Author(s):  
Signe Thiesen ◽  
Elizabeth J Conroy ◽  
Jennifer R Bellis ◽  
Louise E Bracken ◽  
Helena L Mannix ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Adverse Drug Reactions ◽  
Observational Cohort Study ◽  
Hospitalized Children ◽  
Prospective Observational Cohort Study ◽  
Drug Reactions ◽  
Observational Cohort

scholarly journals Incidence and predictors of mortality among children admitted to the pediatric intensive care unit at the University of Gondar comprehensive specialised hospital, northwest Ethiopia: a prospective observational cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e036746
Author(s):  
Nahom Worku Teshager ◽  
Ashenafi Tazebew Amare ◽  
Koku Sisay Tamirat
Keyword(s):  
Intensive Care Unit ◽  
Cohort Study ◽  
Intensive Care ◽  
Critical Illness ◽  
Northwest Ethiopia ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Predictors Of Mortality ◽  
Observational Cohort ◽  
The University

ObjectiveTo determine the incidence and predictors of mortality among children admitted to the paediatric intensive care unit (PICU) at the University of Gondar comprehensive specialised hospital, northwest Ethiopia.DesignA single-centre prospective observational cohort study.ParticipantsA total of 313 children admitted to the ICU of the University of Gondar comprehensive specialised hospital during a one-and-a-half-year period.MeasurementsData were collected using standard case record form, physical examination and patient document review. Clinical characteristics such as systolic blood pressure, pupillary light reflex, oxygen saturation and need for mechanical ventilation (MV) were assessed and documented within the first hour of admission and entered into an electronic application to calculate the modified Pediatric Index of Mortality 2 (PIM 2) Score. We fitted the Cox proportional hazards model to identify predictors of mortality.ResultThe median age at admission was 48 months with IQR: 12–122, 28.1% were infants and adolescents accounted for 21.4%. Of the total patients studied, 59.7% were males. The median observation time was 3 days with (IQR: 1–6). One hundred and two (32.6%) children died during the follow-up time, and the incidence of mortality was 6.9 deaths per 100 person-day observation. Weekend admission (adjusted HR (AHR)=1.63, 95% CI: 1.02 to 2.62), critical illness diagnoses (AHR=1.79, 95% CI: 1.13 to 2.85), need for MV (AHR=2.36, 95% CI: 1.39 to 4.01) and modified PIM 2 Score (AHR=1.53, 95% CI: 1.36 to 1.72) were the predictors of mortality.ConclusionThe rate of mortality in the PICU was high, admission over weekends, need for MV, critical illness diagnoses and higher PIM 2 scores were significant and independent predictors of mortality.

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