Pre-Existing Cellular Immunity to SARS-CoV-2 Through an Immunodominant Epitope

2021 ◽  
Author(s):  
Katie E. Lineburg ◽  
Emma J. Grant ◽  
Srividhya Swaminathan ◽  
Demetra S.M. Chatzileontiadou ◽  
Christopher Szeto ◽  
...  
Keyword(s):  
Cellular Immunity ◽  
Immunodominant Epitope

Spontaneous Cataract in Nude Athymic Mice

1977 ◽  
Vol 35 ◽  
pp. 512-513
Author(s):  
Ronald H. Bradley ◽  
R. S. Berk ◽  
L. D. Hazlett
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Nude Mouse ◽  
Cellular Immunity ◽  
Phosphate Buffer ◽  
Osmium Tetroxide ◽  
Athymic Mice ◽  
Transmission Microscopy ◽  
Mouse Lens ◽  
Scanning Electron

The nude mouse is a hairless mutant (homozygous for the mutation nude, nu/nu), which is born lacking a thymus and possesses a severe defect in cellular immunity. Spontaneous unilateral cataractous lesions were noted (during ocular examination using a stereomicroscope at 40X) in 14 of a series of 60 animals (20%). This transmission and scanning microscopic study characterizes the morphology of this cataract and contrasts these data with normal nude mouse lens.All animals were sacrificed by an ether overdose. Eyes were enucleated and immersed in a mixed fixative (1% osmium tetroxide and 6% glutaraldehyde in Sorenson's phosphate buffer pH 7.4 at 0-4°C) for 3 hours, dehydrated in graded ethanols and embedded in Epon-Araldite for transmission microscopy. Specimens for scanning electron microscopy were fixed similarly, dehydrated in graded ethanols, then to graded changes of Freon 113 and ethanol to 100% Freon 113 and critically point dried in a Bomar critical point dryer using Freon 13 as the transition fluid.

Atopic dermatitis, impaired cellular immunity, and molluscum contagiosum

1978 ◽  
Vol 114 (3) ◽  
pp. 391-393 ◽  
Author(s):  
C. R. Pauly
Keyword(s):  
Atopic Dermatitis ◽  
Cellular Immunity ◽  
Molluscum Contagiosum

Induction of cellular immunity against Mycobacterium tuberculosis

1997 ◽  
Vol 56 (1-3) ◽  
pp. 446
Author(s):  
D da Fonseca
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cellular Immunity

Frequency and functional analysis of variants of the immunodominant epitope NS3–1073: Relevance for vaccine design

2006 ◽  
Vol 44 (08) ◽  
Author(s):  
P Fytili ◽  
G Dalekos ◽  
M Cornberg ◽  
C Sarrazin ◽  
V Schlaphoff ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Vaccine Design ◽  
Immunodominant Epitope

Bedbug cellular immunity

2016 ◽  
Author(s):  
William Thomas Hentley
Keyword(s):  
Cellular Immunity

Immunologic aspects of the nonobese diabetic (NOD) mouse. Abnormalities of cellular immunity

Diabetes ◽  
1983 ◽  
Vol 32 (3) ◽  
pp. 247-253 ◽  
Author(s):  
S. Kataoka ◽  
J. Satoh ◽  
H. Fujiya ◽  
T. Toyota ◽  
R. Suzuki ◽  
...  
Keyword(s):  
Cellular Immunity ◽  
Nod Mouse ◽  
Nonobese Diabetic

Regulation of cellular immunity by Photo(chemo)therapy

10.2741/3530 ◽  
2009 ◽  
Vol Volume (14) ◽  
pp. 4326 ◽  
Author(s):  
Sonja Alexandra Grundmann
Keyword(s):  
Cellular Immunity

Assessment of cellular immunity in oil production operators with an imbalance of lipid metabolism

2020 ◽  
Vol 60 (11) ◽  
pp. 717-719
Author(s):  
Inga N. Alikina ◽  
Olga A. Kazakova
Keyword(s):  
Lipid Metabolism ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Immunological Parameters ◽  
Production Factors ◽  
Cellular And Humoral Immunity ◽  
Atherosclerotic Process

Introduction. Studies indicate the high pathogenetic significance of the immune component in the development of atherosclerosis. The aim of the study is a comparative assessment of immunological parameters in workers of petrochemical production with varying degrees of imbalance in lipid metabolism and the development of the atherosclerotic process. Materials and methods. Men working at an oil production enterprise in the Perm Region were examined. The observation group consisted of oil production operators with a diagnosis of atherosclerosis, the comparison group - with dyslipidemia syndrome. To determine the parameters of lipid metabolism, the results of a biochemical blood test were used. CD-immunogram parameters were identified by flow cytometry. Specific antibodies to benzene were determined by the allergosorbent method. Results. The results of a comparative study of fat metabolism confirmed violations of the physiological ratio of lipids in the blood of oil production workers, which were expressed in a significant imbalance in the levels of lipidogram. There was an increased level of specific IgG antibodies to benzene in the observation group in relation to the comparison group. An imbalance of cellular immunity was found, which was characterized by signs of indicators activation of cellular differentiation clusters. Conclusions. Studies of immune system compartments demonstrate excessive activation of cellular and humoral immunity in oil production workers under the influence of a combination of harmful production factors. The simultaneously formed imbalance of lipid metabolism is associated with various degrees of clinical manifestation of atherosclerotic disorders, with the influence of harmful production factors, aggressiveness of cellular and humoral immunity, and smoking.

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