Assessment of cellular immunity in oil production operators with an imbalance of lipid metabolism

2020 ◽  
Vol 60 (11) ◽  
pp. 717-719
Author(s):  
Inga N. Alikina ◽  
Olga A. Kazakova
Keyword(s):  
Lipid Metabolism ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Immunological Parameters ◽  
Production Factors ◽  
Cellular And Humoral Immunity ◽  
Atherosclerotic Process

Introduction. Studies indicate the high pathogenetic significance of the immune component in the development of atherosclerosis. The aim of the study is a comparative assessment of immunological parameters in workers of petrochemical production with varying degrees of imbalance in lipid metabolism and the development of the atherosclerotic process. Materials and methods. Men working at an oil production enterprise in the Perm Region were examined. The observation group consisted of oil production operators with a diagnosis of atherosclerosis, the comparison group - with dyslipidemia syndrome. To determine the parameters of lipid metabolism, the results of a biochemical blood test were used. CD-immunogram parameters were identified by flow cytometry. Specific antibodies to benzene were determined by the allergosorbent method. Results. The results of a comparative study of fat metabolism confirmed violations of the physiological ratio of lipids in the blood of oil production workers, which were expressed in a significant imbalance in the levels of lipidogram. There was an increased level of specific IgG antibodies to benzene in the observation group in relation to the comparison group. An imbalance of cellular immunity was found, which was characterized by signs of indicators activation of cellular differentiation clusters. Conclusions. Studies of immune system compartments demonstrate excessive activation of cellular and humoral immunity in oil production workers under the influence of a combination of harmful production factors. The simultaneously formed imbalance of lipid metabolism is associated with various degrees of clinical manifestation of atherosclerotic disorders, with the influence of harmful production factors, aggressiveness of cellular and humoral immunity, and smoking.

Immune profile of oil production enterprise employees

2019 ◽  
pp. 937-939
Author(s):  
I. N. Alikina ◽  
O. V. Dolgikh
Keyword(s):  
Cell Death ◽  
Cellular Immunity ◽  
Comparison Group ◽  
Oil Production ◽  
The State ◽  
Observation Group ◽  
Immune Profile ◽  
Cellular Immunodeficiency ◽  
Perm Region ◽  
Male Workers

Introduction. The assessment of the immune profile of employees of the oil-producing enterprise, the formation of the immunological status of which is determined by the conditions of harmful production factors affecting their health.The aim of the study was to assess the state of cellular immunity in oil-producing enterprise employees (on the example of the Perm region).Materials and methods. 60 men working at the oil-producing enterprise of the Perm region were examined. In the observation group (n=30) were included surveyed male workers-operators of oil production, in the comparison group — surveyed male workers — representatives of the administrative apparatus. The state of cellular immunity was assessed by indicators of cellular regulation and apoptosis. Cell differentiation marker T-reg-CD4+CD127 -, expression level of Bcl–2, Bax, p53 proteins, TNFR receptors and AnnexinV-FITC+7AAD negative cells were determined by flow cytometry.Results. The comparative analysis with physiological norm indicators allowed to reveal reliable hyperproduction of membrane and intracellular factors of cellular immunity in oil production operators. Expression of regulatory marker CD127-, proteins Bax, Bcl–2 and p53, TNFR receptor content and AnnexinV-FITC+7AAD negative cells responsible for natural cell death (p<0.05) was established. The indicators of the observation group differed significantly from those of the comparison group. There was a significant inhibition of expression of CD-marker CD127-and apoptic protein Bcl–2 by more than 10%, an increase in TNFR, AnnexinV-FITC+7AAD negative cells, protein Bax and p53 by 1.3, 1.6 and 1.2 times, respectively.Conclusions. The results of immunological screening allowed to establish an imbalance of cellular immunity in oil-producing enterprise workers — a deficiency of regulatory cells and a protein-controller of cell death with simultaneous excessive activation of cell reception, which later forms the phenomenon of cellular immunodeficiency. The high sensitivity of the membrane and cytoplasmic components of the immune profile allows them to be used as indicators of the health status of oil production operators, timely identify the development of regulatory imbalance of the immune system, early violations of cell-associated pathological processes (cellular immunodeficiency, autoimmune and proliferative processes), as well as timely and effective implementation of measures to prevent the development of production-related diseases working at oil production facilities.

scholarly journals DYNAMICS OF CLINICAL AND IMMUNOLOGICAL INDICATORS IN COMPLEX TREATMENT OF CANDIDA-ASSOCIATED PERIODONTITIS

2019 ◽  
Vol 15 (2) ◽  
pp. 128-134
Author(s):  
Фания Мирсаева ◽  
Faniya Mirsaeva ◽  
Тимур Ханов ◽  
Timur Hanov
Keyword(s):  
Humoral Immunity ◽  
Inflammatory Process ◽  
Antagonistic Activity ◽  
Average Degree ◽  
Complex Treatment ◽  
Immunological Parameters ◽  
Periodontal Tissues ◽  
Two Component ◽  
Cellular And Humoral Immunity ◽  
Antimycotic Drug

Subject. The problem of complex treatment of candida-associated periodontitis is considered. The authors propose a two-component probiotic, which, due to antagonistic activity regarding periodontal pathogenic infection and fungi of the genus Candida, leads to the relief of the inflammatory process, positive dynamics and stabilization of immunological parameters. The aim ― to evaluate the dynamics of clinical and immunological parameters in the complex treatment of candida-associated periodontitis with an average degree of quantitative seeding of periodontal pockets using a two-component probiotic. Methodology. A clinical and laboratory examination of three groups (I, II, III) of patients with Candida-associated periodontitis with an average degree of quantitative contamination of periodontal pockets (> 3 <6 CFU / ml) was carried out. Patients I groups were prescribed the well-known complex treatment including an antimycotic drug, patients II groups included a two-component probiotic locally in the treatment complex, and patients III groups locally and per os. The state of the oral mucosa was assessed, PMA, PI, OHI - S were determined, and indicators of cellular and humoral immunity were examined. Results. The study made it possible to establish that the inclusion of a two-component probiotic in the complex of treatment of candida-associated periodontitis with an average degree of quantitative contamination of periodontal pockets with fungi of the genus Candida contributes to the relief of the inflammatory process, an increase in phagocytosis, the metabolic activity of neutrophils, the concentration of immunoglobulins A, lysozyme levels, and a decrease in the concentration of immunoglobulins. G, positive dynamics of other indicators of immunity and their stabilization. Conclusions. The inclusion of a two-component probiotic from two strains in the complex treatment of chronic hepatitis C associated with fungi of the genus Candida contributes to the rapid relief of the inflammatory process in periodontal tissues, positive dynamics and stabilization of cellular and humoral immunity parameters.

Changes in biochemical parameters in workers exposed to chemical production factors (heptane and hexane)

2021 ◽  
Vol 61 (6) ◽  
pp. 379-384
Author(s):  
Marina A. Zemlyanova ◽  
Juliya V. Koldibekova ◽  
Ekaterina V. Peskova ◽  
Victor M. Ukhabov
Keyword(s):  
Blood Serum ◽  
Blood Plasma ◽  
Biochemical Parameters ◽  
Comparison Group ◽  
Processing Plant ◽  
Observation Group ◽  
Chemical Production ◽  
Production Factors ◽  
Nasal Secretions

Introduction. Long-term constant exposure to certain representatives of aliphatic hydrocarbons during the extraction and processing of potash ore can lead to pathological changes on critical organs and systems in production workers. The study aims to evaluate the change in biochemical parameters in workers exposed to chemical production factors (heptane and hexane). Materials and methods. The study of the content of hexane, heptane in the air of the working area and the urine of workers, the establishment of changes in several biochemical (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, glutamyltransferase, epinephrine, and norepinephrine) and general clinical (eosinophils, neutrophils and the eosinophilia index) indicators, modeling of cause-and-effect relationships. Results. Specialists found in the observation group relative to the comparison group: increased levels of heptane and hexane in the urine up to 1.7 times; increased levels of adrenaline and norepinephrine in the blood plasma up to 1.8 times, up to 1.4 times ALAT and γ-GT in the blood serum, up to 1.9 times neutrophils in the nasal secretions associated with increased concentrations of heptane and hexane in the urine; an increase of up to 4.4 times in the frequency of diseases of the nervous system, respiratory organs, and digestion. Conclusions. In the air of the working area of the workers of the flotation shop of the sylvinite processing plant, the concentrations of the studied limit hydrocarbons were below the detection limit; there is an increased concentration of heptane and hexane in the urine. In the workers of the studied production, an increase of 1.4-1.8 times in the level of adrenaline and norepinephrine in blood plasma, 1.2-1.4 times in ALAT and γ-GT in blood serum, 1.9 times in the content of neutrophils in nasal secretions, which characterizes adverse effects from the respiratory, digestive and nervous systems. We proved the dependence of the increased frequency of diseases of the listed organs and systems on the increased concentration of heptane in the urine (R2=0.26-0.43; p=0.0001-0.028).

scholarly journals PSVI-22 Immunity indicators of calves obtained from cows with ketosis during the treatment process

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 199-199
Author(s):  
Sergey Kovalev ◽  
Anastasia Nikitina ◽  
Polina Anipchenko ◽  
Anatoly Stekolnikov ◽  
Pavel Kiselenko ◽  
...  
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
B Lymphocytes ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Treatment Process ◽  
Absolute Number ◽  
Relative Content ◽  
Newborn Calves ◽  
Cellular And Humoral Immunity

Abstract The purpose of these studies was to determine the indicators of cellular and humoral immunity of calves. Compared to calves obtained from untreated cows, the number of T-lymphocytes in young calves born from cows treated with Timolin increased the level of T-cells to 32.9%, while using Timosplenin 45%. As a result of the use of immunomodulators in treating cows with ketosis in mothers, the relative content of T-lymphocytes in the blood of calves born from them increased when using the drug Leucogen by 1.7 times, Timosplenin by 2.3 times, Timalin in 2.2 times. The use of Leucogen for cows with ketosis contributed to an increase in the percentage of B cells in the blood of calves born by 23%, Timosplenin 83%, and Timalin 42%. At the same time, the absolute number of B-lymphocytes in the treatment of “Leucogen” increased 1.9 times and reached the level of healthy calves, in the treatment with the preparations “Timosplenin” and “Timalin” - the increase was, respectively, 3.0 and 2.3 times and was higher this indicator in young animals born from healthy calves. Thus, the inclusion of dry immunomodulators in the treatment regimen of patients with ketosis leads not only to normalization of metabolism, but is also accompanied by an increase in the level of cellular immunity factors in calves born from them. Under the influence of “Leucogen,” the percentage of lymphocytes was normalized, whereas with the introduction of “Timalin” and “Timosplenin,” the content of this type of cells in newborn calves even exceeded those in healthy young.

scholarly journals Analysis of comorbid pathology in oil producers

2021 ◽  
Vol 100 (5) ◽  
pp. 464-470
Author(s):  
Olga Y. Ustinova ◽  
Nina V. Zaitseva ◽  
Vitalii G. Kostarev ◽  
Elena M. Vlasova ◽  
Alyona A. Vorobyova ◽  
...  
Keyword(s):  
Working Conditions ◽  
Work Experience ◽  
Oil And Gas ◽  
Comparison Group ◽  
Significant Risk ◽  
Oil Production ◽  
Gas Production ◽  
Observation Group ◽  
Oil And Gas Production ◽  
Average Work

Aim of the study. To analyze the patterns of the comorbidity pathology formation in employees occupied in oil production. Materials and methods. Observation group - 292 employees of the oil production enterprise (100% men). The average age was 39.4 ± 10.6 (20-65) years. Average work experience is 13.1 ± 9.6 (3-22) years. The comparison group included 65 employees working in the management of the enterprise. The average age is 40.2 ± 9.8 (20-65) years. Average work experience is 18.5 ± 9.5 (5-23) years. Observation group - 292 oil and gas production operators (OGP) - 100% men. The study involved a comprehensive research program, results analysis, and mathematical modeling. Results. It is typical for oil and gas production operators to be exposed to a complex impact of harmful production factors: industrial noise, the intensity of work, and physical overload combined with chemical factors. A prior occupational risk to the employees under mentioned working conditions was classified from low (moderate) risk to medium (significant) risk. The age of employees with developed comorbid pathology in the observation group was 31.7 ± 5.4 years, work experience in the specified working conditions was 4.6 ± 1.1 years; the age of workers in the comparison group was 35.4 ± 3.9 years, work experience was 7.4 ± 2.7 years. The results of functional studies have demonstrated a complex of abnormalities in workers with little expressed clinical symptomatology. Analysis of comorbid pathology showed an increase in n according to CIRS score, increasing the working experience among oil and gas operators. Conclusion. Comorbid pathology occurs in oil production workers within ten years of working experience under conditions of combined occupational and non-occupational factors. In the comorbid pathology development, both induced intrasystemic and intersystemic disorders significantly worsens the working life prognosis.

Patients with Diamond Blackfan Anaemia Have Abnormalities of Cellular and Humoral Immunity

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 3484-3484 ◽  
Author(s):  
Deena Iskander ◽  
Yvonne Harrington ◽  
Irene Roberts ◽  
Anastasios Karadimitris ◽  
Josu de la Fuente
Keyword(s):  
T Lymphocytes ◽  
Humoral Immunity ◽  
Lymphocyte Subsets ◽  
Conflicts Of Interest ◽  
Bone Marrow Failure ◽  
Immunological Parameters ◽  
Number Of Patients ◽  
Increased Risk ◽  
Cellular And Humoral Immunity ◽  
Diamond Blackfan Anaemia

Abstract Abstract 3484 Diamond Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome characterised by anaemia, physical anomalies and an increased risk of malignancy. Although the hallmark of DBA is anaemia secondary to pure red cell aplasia, some patients exhibit additional cytopaenias, such as neutropaenia, suggestive of a more widespread defect in haemopoietic development. Aberrant immunity causing infections has been reported in a proportion of patients, but the scope and precise nature of these immunological defects are yet to be elucidated. Fifty-nine patients with clinical and laboratory features consistent with Diamond Blackfan anaemia attend the DBA clinic at St. Mary's Hospital. The median age is 8.8 years (1.1 – 40.9). Two patients presented in utero (3.4%), 36 patients (61%) in the first twelve weeks of life, 12 patients (20.3%) from 3 to 12 months, 6 patients (10.2%) 1 to 5 years, 2 patients (3.4%) 5 to 10 years and 1 patient (1.7%) later than 18 years of age. Thirty-five patients (59.3%) had systemic abnormalities [including cardiac involvement in 17 patients (28.8%)], 7 patients (11.9%) had short stature only and 17 patients (28.8%) no systemic abnormalities. Infection was implicated in the death of 2 out of 3 patients in this cohort. Immunological parameters were available for 37 of the patients (age 18 months to 40 years). A history of infections was reported in 16/37 (43.2%) patients. Three patients had at least 1 serious infective episode requiring hospital admission (Salmonella gastroenteritis, Clostridum difficile gastroenteritis and neonatal pneumonia) and 13/37 patients experienced recurrent infections (7/37 respiratory tract, 1/7 urinary tract, 2/37 otitis media and 3/37 infections affecting different systems). In 2/16 patients infections occurred during treatment with corticosteroids. Consistent lymphopenia was found in 7/37 (18.9%) patients. Specific deficiencies in lymphocyte subsets were identified by immunophenotyping as summarised below. Abnormalities in one or more subsets were identified in the 7 patients with low total lymphocyte counts and a further 7 patients with normal total lymphocytes counts. A low B lymphocyte fraction was the most commonly detected abnormality, present in 12/37 (32.4% patients). Three patients (8.1%) had at least 3 abnormalities in lymphocytes subsets. Lymphocyte subsets Number patients (%) with deficiency in absolute count Median count in patients with deficiency (cells/μL) Range of counts in patients with deficiency (cells/μL) CD45+ total lymphocytes 7 (18.9) 838 387–1447 CD3+ T lymphocytes 4 (10.8) 419 266–661 CD4+ T lymphocytes 2 (5.4) 182 133–231 CD8+ T lymphocytes 4 (10.8) 141.5 83–165 CD56+ Natural Killer cells 6 (16.2) 72 49–86 CD19+ B lymphocytes 12 (32.4) 122.5 31–191 Low levels of one or more immunoglobulin isotypes were detected in 4/34 (11.8%) patients. An additional 5/32 (15.6%) patients showed a selective deficiency in one of the four IgG subclasses. Importantly, these abnormalities were masked by normal total IgG levels. Of 30 patients who had undergone immunisation against measles, mumps and rubella, immunity to all 3 pathogens was confirmed in only 13 (43.3%) patients (as determined by positive IgG serology). We observed equivocal or negative specific IgG antibodies to measles in 13/30 (43.3%), mumps in 7/30 (23.3%) and rubella in 6/30 (20%). Haemophilus B antibody titres in 30 patients following immunisation were optimum (>1mg/L) in 14/30 (46.7%), minimally protective (>0.15 mg/L) in 11/30 (36.7%) and inadequate (<0.15 mg/L) in 5/30 (16.7%). In summary, DBA patients have defects in both cellular and humoral immunity independent of treatment with steroids, with combined abnormalities of both arms of immunity in 5/37 (13.5%) patients and defects in B cells being overall the most common abnormality. In addition, a large number of patients had subnormal responses to vaccination. These findings are likely to have a role in the increased number of infections found in DBA. Disclosures: No relevant conflicts of interest to declare.

Features of risk factors of development of the production caused pathology at workers of metallurgical production

2019 ◽  
pp. 926-930 ◽  
Author(s):  
E. M. Vlasova ◽  
E. A. Polevaya ◽  
M. M. Poroshina ◽  
M. I. Tiunova ◽  
V. B. Alekseev
Keyword(s):  
Risk Factors ◽  
Hydrogen Chloride ◽  
Metabolic Disorders ◽  
Comparison Group ◽  
Working Life ◽  
Observation Group ◽  
Industrial Enterprises ◽  
Production Factors ◽  
Respiratory Pathology ◽  
Chemical Factors

Introduction. The relevance of the study of cardiovascular diseases (CVD) as a production-related pathology in workers at industrial enterprises is due to the presence in the technological process of production factors (noise, general vibration, microclimate, severity of labor, chemical factors), potentially capable of provoking the development of CVD.The aim of the study was to assess respiratory and metabolic disorders, which are risk factors for CVD, in workers exposed to dust, chlorine and hydrogen chloride.Materials and methods. 139 patients working under the influence of dust, chlorine and hydrogen chloride were examined. Among the surveyed 74 women and 65 men. The comparison group (45 people) consisted of 20 women and 25 men who were not exposed to harmful factors of production during their working life.Results. In the group of workers exposed to occupational exposure to dust, chlorine and hydrochloride vapors, it was revealed that the proportion of workers with arterial hypertension was 33.3%, in the comparison group–17.6%, p<0.05 (RR 1.99; 95% CI 1.01–3.93; EF=47%; the degree of professional conditioning is average). The volume of forced exhalation per 1 second (FEV1) in the observation group was 3.18±0.14 l, and in the comparison group–4.1±0.20 l (p<0.001). The level of total cholesterol in the observation group was 5.72±0.13 mmol / l, and in the comparison group–5.16±0.23 mmol / l (p<0.05). The observation group showed a decrease in HDL (1.35±0.04 mmol / l vs. 1.64±0.10 mmol / l in the comparison group, p<0.05) and an increase in triglycerides (2.3±0.17 mmol/l versus 1.51±0.16 mmol/l in the comparison group, p<0.05).Conclusions. In the group of workers exposed to professional dust, chlorine and hydrochloride vapors, a decrease in the speed parameters of the external respiratory function, the development of proatherogenic metabolic disorders, and an increase in laboratory indicators of inflammation were revealed. These changes can lead to early manifestation of cardiovascular and respiratory pathology in this category of workers.

scholarly journals Humoral and Cellular Immunity in Children with Mycoplasma pneumoniae Infection: a 1-Year Prospective Study

2005 ◽  
Vol 12 (10) ◽  
pp. 1246-1250 ◽  
Author(s):  
Iwona Stelmach ◽  
Malgorzata Podsiadłowicz-Borzęcka ◽  
Tomasz Grzelewski ◽  
Pawel Majak ◽  
Wlodzimierz Stelmach ◽  
...  
Keyword(s):  
Prospective Study ◽  
Mycoplasma Pneumoniae ◽  
Humoral Immunity ◽  
Cellular Immunity ◽  
Immunoglobulin G ◽  
Serum Immunoglobulin ◽  
Humoral And Cellular Immunity ◽  
Cellular And Humoral Immunity ◽  
Lymphocyte Phenotypes ◽  
Mycoplasma Pneumoniae Infection

ABSTRACT To determine whether children have persistent abnormalities in cellular and humoral immunity development after acute Mycoplasma pneumoniae infection, serum immunoglobulin G (IgG), IgA, IgM, and IgE levels and lymphocyte phenotypes were determined. There were no changes in the levels of IgG, IgM, IgA, or CD4+ or CD19+ lymphocytes that were measured in M. pneumoniae-positive patients after 3 months or after 12 months, but there were increases in these in M. pneumoniae-negative patients. Serum IgE increased in M. pneumoniae-positive patients. We have shown alterations in immunity development after M. pneumoniae infection.

scholarly journals Bactericidal Activity of Serum By Brucella Abortus RB51 Outer Membrane Protein’s Combined By Brucella Abortus S99 Lipopolysaccharide Induction

2021 ◽  
Author(s):  
Adeleh Attar ◽  
Hamed Afkhami ◽  
Mansoor Khaledi ◽  
Mahdi S.Sadati
Keyword(s):  
Humoral Immunity ◽  
Cellular Immunity ◽  
Bactericidal Activity ◽  
Brucella Abortus ◽  
Important Method ◽  
The Third ◽  
Serum Bactericidal Assay ◽  
Cellular And Humoral Immunity ◽  
Combined Vaccine

Abstract Brucellosis vaccines are designed to induce the cellular immunity. An effective brucellosis vaccine is one that could induce both cellular and humoral immunity. Serum Bactericidal Assay(SBA) is an important method for the determination of vaccine humoral immunity. This study is the first to observe humoral immunity in brucellosis by SBA. Extracted B.abortus LPS and OMP’s were injected to rabbits. Group1 injected by 25µg of LPS, Group2 injected by 50µg of OMP ‘s and Group3 injected by 1ml of combined vaccine, 3 times every 2 weeks. The Groups were challenged with B.abortus 544 in the second injection. Sera were separated 2 weeks after the last injection. SBA was performed, each well was streak cultured into a plate of Brucella Agar. Colony count was done for each plate. Results have shown, the third injection of the combined vaccine, had the highest titer of 1/64, and the efficacy of the vaccine was %87.71.

Age-related features of the immune status associated with the development of arterial hypertension in employees of an oil production enterprise

2020 ◽  
Vol 60 (11) ◽  
pp. 842-844
Author(s):  
Natalia A. Nikonoshina
Keyword(s):  
Blood Pressure ◽  
Work Experience ◽  
Blood Cells ◽  
Immune Status ◽  
Comparison Group ◽  
Oil Production ◽  
Observation Group ◽  
Age Related ◽  
Specific Igg ◽  
Perm Region

Introduction. Arterial hypertension (AH) is a multifactorial disease, the main risk factors of which are environmental determinants, the duration and level of their exposure, as well as the age of the examined population. The conditions of the production environment are characterized by a more pronounced effect of technogenic factors compared to the environment, which creates prerequisites for the development of adaptation disorders and an increased risk of hypertension among employees of the oil production enterprise. The aim of study was to analyze age - related features of the immune status associated with the development of AH in employees of an oil production enterprise in the Perm region. Materials and methods. 150 oil production operators exposed to chronic exposure to harmful production factors were examined. The observation group consisted of 67 people over 40 years of age with more than 10 years of work experience who had episodes of increased blood pressure (BP). The comparison group consisted of 73 men under 45 years of age with less than 10 years of experience and no cardiovascular pathology. Determination of the total IgE, IgG to benzene, and VEGF content was performed by the ELISA method. The content of CD3+CD25+, CD127-, CD3+CD95+, and Bax was determined by flow cytometry. Phagocytic activity of white blood cells was studied using formalized sheep red blood cells. The relationship between age and seniority with the development of episodes of increased blood pressure was evaluated using the odds - OR ratio indicator. Statistical processing of the results was performed using the Statistica 6.0 software package. Differences between groups were considered significant at p<0.05. Results. Episodes of increased blood pressure in employees of an oil production enterprise in the Perm region are significantly associated with work experience of more than 10 years when they reach the age of 40 years (p<0.05). The observation group is characterized by an increased (p<0.05) level of General (IgE General) and specific (IgG to benzene) sensitization. A decrease (p<0.05) in the CD3+CD25+ content relative to the comparison group was found against the background of an increase (p<0.05) in the level of regulatory CD127 lymphocytes. Episodes of increased blood pressure in the observation group are associated (p<0.05) with a reduced (p<0.05) level of the Bax protein and CD95+-receptor of lymphocytes relative to the comparison group. At the same time, signs of phagocytosis activation (p<0.05) were established according to the criteria of phagocytosis percentage, phagocytic number, and absolute phagocytosis relative to the comparison group. Conclusions. Detected changes in immune regulation: an increase in the level of General (IgE General) and specific (IgG to benzene) sensitization, suppression of the immune response (CD3+CD25+, CD127-) and apoptosis (CD3+CD95+, Bax) against the background of phagocytosis activation characterize the development of hypertension in employees of an oil production enterprise older than 40 years with more than 10 years of experience in this industry.

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