SARS-CoV-2 Seroprevalence and Accuracy Diagnostic Evaluation During a Covid-19 Outbreak in a Major Penitentiary Complex in Brazil, June-July 2020: A Population-Based Study

SARS-CoV-2 infection fatality ratios (IFR) remain controversially discussed with implications for political measures. The German county of Tirschenreuth suffered a severe SARS-CoV-2 outbreak in spring 2020, with particularly high case fatality ratio (CFR). To estimate seroprevalence, underreported infections, and IFR for the Tirschenreuth population aged ≥14 years in June/July 2020, we conducted a population-based study including home visits for the elderly, and analyzed 4203 participants for SARS-CoV-2 antibodies via three antibody tests. Latent class analysis yielded 8.6% standardized county-wide seroprevalence, a factor of underreported infections of 5.0, and 2.5% overall IFR. Seroprevalence was two-fold higher among medical workers and one third among current smokers with similar proportions of registered infections. While seroprevalence did not show an age-trend, the factor of underreported infections was 12.2 in the young versus 1.7 for ≥85-year-old. Age-specific IFRs were <0.5% below 60 years of age, 1.0% for age 60–69, and 13.2% for age 70+. Senior care homes accounted for 45% of COVID-19-related deaths, reflected by an IFR of 7.5% among individuals aged 70+ and an overall IFR of 1.4% when excluding senior care home residents from our computation. Our data underscore senior care home infections as key determinant of IFR additionally to age, insufficient targeted testing in the young, and the need for further investigations on behavioral or molecular causes of the fewer infections among current smokers.

Download Full-text

The magnitude and distribution of infectious intestinal disease in Malta: a population-based study

Epidemiology and Infection ◽

10.1017/s0950268806007795 ◽

2007 ◽

Vol 135 (8) ◽

pp. 1282-1289 ◽

Cited By ~ 19

Author(s):

C. GAUCI ◽

H. GILLES ◽

S. O'BRIEN ◽

J. MAMO ◽

I. STABILE ◽

...

Keyword(s):

Burden Of Illness ◽

Population Level ◽

Population Based ◽

Intestinal Disease ◽

Sources Of Information ◽

Cross Sectional ◽

Population Based Study ◽

Infectious Intestinal Disease ◽

Duration Of Illness ◽

June July

SUMMARYRoutine sources of information on infectious intestinal disease (IID) capture a fraction of the actual disease burden. Population studies are required to measure the burden of illness. A retrospective age-stratified cross-sectional telephone study was carried out in Malta in order to estimate the magnitude and distribution of IID at population level. A random sample of 3504 persons was interviewed by a structured questionnaire between April 2004 and December 2005. The response rate was 99·7%. From the study, the observed standardized monthly prevalence was 3·18% (95% CI 0·7–5·74) with 0·421 (95% CI 0·092–0·771) episodes of IID per person per year. The monthly prevalence was higher in the <5 years age group and in females aged 31–44 years. The mean duration of illness was 6·8 days and a median duration of 3 days. A bimodal seasonal distribution was observed with peaks in June–July and October–November.

Download Full-text