Deficient Thyroid Hormone Transport to the Brain Leads to Impairments in Axonal Caliber and Oligodendroglial Differentiation

2021 ◽  
Author(s):  
Víctor Valcárcel-Hernández ◽  
Daniela López-Espíndola ◽  
Marina Guillén-Yunta ◽  
Ángel García-Aldea ◽  
Inés López de Toledo-Soler ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Transport ◽  
The Brain

scholarly journals Deficient thyroid hormone transport to the brain leads to impairments in axonal caliber and oligodendroglial development

2021 ◽  
pp. 105567
Author(s):  
Víctor Valcárcel-Hernández ◽  
Daniela López-Espíndola ◽  
Marina Guillén-Yunta ◽  
Ángel García-Aldea ◽  
Inés López de Toledo-Soler ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Transport ◽  
The Brain

Transthyretin – a forgotten thyroid hormone transport protein

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S44-S45
Author(s):  
J. RAMAKER ◽  
P. C. SCRIBA ◽  
W. G. WOOD
Keyword(s):  
Thyroid Hormone ◽  
Transport Protein ◽  
Hormone Transport

Thyroid hormone transport into target tissues

2016 ◽  
Author(s):  
Jiesi Chen ◽  
Steffen Mayerl ◽  
Heike Heuer
Keyword(s):  
Thyroid Hormone ◽  
Hormone Transport

Thyroid Hormone Metabolism and Action in the Brain and Pituitary

2000 ◽  
Vol 27 (1) ◽  
pp. 1-7 ◽  
Author(s):  
J. Kohrle
Keyword(s):  
Thyroid Hormone ◽  
Hormone Metabolism ◽  
Thyroid Hormone Metabolism ◽  
The Brain

scholarly journals Thyroid Hormone and the Neuroglia: Both Source and Target

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Petra Mohácsik ◽  
Anikó Zeöld ◽  
Antonio C. Bianco ◽  
Balázs Gereben
Keyword(s):  
Thyroid Hormone ◽  
Cell Function ◽  
Hormone Regulation ◽  
Mediobasal Hypothalamus ◽  
Iodothyronine Deiodinase ◽  
Neuronal Gene ◽  
Health And Disease ◽  
And Function ◽  
The Brain

Thyroid hormone plays a crucial role in the development and function of the nervous system. In order to bind to its nuclear receptor and regulate gene transcription thyroxine needs to be activated in the brain. This activation occurs via conversion of thyroxine to T3, which is catalyzed by the type 2 iodothyronine deiodinase (D2) in glial cells, in astrocytes, and tanycytes in the mediobasal hypothalamus. We discuss how thyroid hormone affects glial cell function followed by an overview on the fine-tuned regulation of T3 generation by D2 in different glial subtypes. Recent evidence on the direct paracrine impact of glial D2 on neuronal gene expression underlines the importance of glial-neuronal interaction in thyroid hormone regulation as a major regulatory pathway in the brain in health and disease.

scholarly journals Thyroid hormones and seasonal reproductive neuroendocrine interactions

Reproduction ◽  
2008 ◽  
Vol 136 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Nobuhiro Nakao ◽  
Hiroko Ono ◽  
Takashi Yoshimura
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Biological Process ◽  
Critical Role ◽  
Day Length ◽  
Seasonal Reproduction ◽  
Seasonal Breeding ◽  
Length Changes ◽  
Neuroendocrine Axis ◽  
The Brain

Many animals that breed seasonally measure the day length (photoperiod) and use these measurements as predictive information to prepare themselves for annual breeding. For several decades, thyroid hormones have been known to be involved in this biological process; however, their precise roles remain unknown. Recent molecular analyses have revealed that local thyroid hormone activation in the hypothalamus plays a critical role in the regulation of the neuroendocrine axis involved in seasonal reproduction in both birds and mammals. Furthermore, functional genomics analyses have revealed a novel function of the hormone thyrotropin. This hormone plays a key role in signaling day-length changes to the brain and thus triggers seasonal breeding. This review aims to summarize the currently available knowledge on the interactions between elements of the thyroid hormone axis and the neuroendocrine system involved in seasonal reproduction.

Integrative view of serpins in health and disease: the contribution of serpinA3

2020 ◽  
Author(s):  
Andrea Sanchez-Navarro ◽  
Isaac González-Soria ◽  
Rebecca Caldiño-Bohn ◽  
Norma A. Bobadilla
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Cellular Processes ◽  
Hormone Transport ◽  
Integrative View ◽  
Health And Disease ◽  
The Brain ◽  
Regulation Of Blood Pressure ◽  
Common Function

Serpins are a superfamily of proteins characterized by their common function as serine protease inhibitors. So far, 36 serpins from nine clades have been identified. These proteins are expressed in all the organs and are involved in multiple important functions such as the regulation of blood pressure, hormone transport, insulin sensitivity, and the inflammatory response. Diseases such as obesity, diabetes, cardiovascular, and kidney disorders are intensively studied to find effective therapeutic targets. Given serpins' outstanding functionality, the deficiency or overexpression of certain types of serpin have been associated with diverse pathophysiological events. In particular, we will focus on reviewing the studies evaluating the participation of serpins, and particularly SerpinA3, in diverse diseases that occur in relevant organs such as the brain, retinas, corneas, lungs, cardiac vasculature, and kidneys. In this review, we summarize the role of serpins in physiological and pathophysiological processes, as well as recent evidence on the crucial role of SerpinA3 in several pathologies. Finally, we emphasize the importance of SerpinA3 in regulating cellular processes such as angiogenesis, apoptosis, fibrosis, oxidative stress, and the inflammatory response.

Thyroid Hormone Transport from Blood into Brain Cells

1989 ◽  
pp. 39-50 ◽  
Author(s):  
Jacob Robbins ◽  
Edison Goncalves ◽  
Mark Lakshmanan ◽  
Daniels Foti
Keyword(s):  
Thyroid Hormone ◽  
Brain Cells ◽  
Hormone Transport
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