Cost-Effectiveness of Oral Pre-Exposure Prophylaxis and Expanded Antiretroviral Therapy for Preventing HIV Infections in the Presence of Drug Resistance: A Mathematical Modelling Study

2021 ◽  
Author(s):  
Xinye Jin ◽  
Lingen Shi ◽  
Congyue Wang ◽  
Tao Qiu ◽  
Yi Yin ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cost Effectiveness ◽  
Antiretroviral Therapy ◽  
Mathematical Modelling ◽  
Hiv Infections ◽  
Exposure Prophylaxis ◽  
Modelling Study

scholarly journals The cost-effectiveness of oral HIV pre-exposure prophylaxis and early antiretroviral therapy in the presence of drug resistance among men who have sex with men in San Francisco

BMC Medicine ◽  
2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Mingwang Shen ◽  
Yanni Xiao ◽  
Libin Rong ◽  
Lauren Ancel Meyers ◽  
Steven E. Bellan
Keyword(s):  
Drug Resistance ◽  
Cost Effectiveness ◽  
Antiretroviral Therapy ◽  
San Francisco ◽  
Sex With Men ◽  
Exposure Prophylaxis ◽  
The Cost

Cost-effectiveness analysis of pre-exposure prophylaxis for HIV-1 prevention in the Netherlands: a mathematical modelling study

2016 ◽  
Vol 16 (12) ◽  
pp. 1423-1429 ◽  
Author(s):  
Brooke E Nichols ◽  
Charles A B Boucher ◽  
Marc van der Valk ◽  
Bart J A Rijnders ◽  
David A M C van de Vijver
Keyword(s):  
Cost Effectiveness ◽  
The Netherlands ◽  
Mathematical Modelling ◽  
Cost Effectiveness Analysis ◽  
Effectiveness Analysis ◽  
Exposure Prophylaxis ◽  
Hiv 1 ◽  
Modelling Study

scholarly journals Cost-Effectiveness Analysis of the Daily HIV Pre-Exposure Prophylaxis in Men who Have Sex with Men in Barcelona

2021 ◽  
Author(s):  
Francesc López Seguí ◽  
Unai Oyon Lerga ◽  
Laura Laguna Marmol ◽  
Pep Coll ◽  
Angels Andreu ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cost Saving ◽  
Time Horizon ◽  
Cost Savings ◽  
Health Indicators ◽  
Hiv Infections ◽  
Sex With Men ◽  
Exposure Prophylaxis ◽  
Oral Prep

Introduction: Pre-Exposure Prophylaxis (PrEP) for HIV prevention has been implemented in several countries. Previous literature has shown that its cost-effectiveness (and, under some specifications, cost-saving character) is dependent on the reduction in price due to generics, the time-horizon and its effectiveness. The intervention has never been studied in Catalonia, a territory with extensive implementation. Methods: Economic evaluation of the implementation of HIV pre-exposition prophylaxis using administrative data from Men who have Sex with Men (MSM) who receive the treatment (at the generic price). A deterministic compartmental model and a social perspective with a micro-costing approach over the time horizon 2022-2062 are used. A baseline 86% effectiveness of PrEP is assumed. Results: Daily oral PrEP is found to be cost-saving: discounted savings in costs are attained after 16 years, and after 40 years they reach 81 million euros. In terms of health indicators, 10,322 additional discounted QALYs are generated by the intervention. Results are sensitive to sexual behavioral patterns among MSM, the price of PrEP (reduced if offered on-demand), its effectiveness and the discount rate. Conclusions: The use and promotion of PrEP in Catalonia is predicted to result in substantial health and monetary benefits because of reductions in HIV infections. Short-term investments in the promotion of PrEP will result in important cost-savings in the long term.

scholarly journals Impact and cost-effectiveness of chlamydia testing in Scotland: a mathematical modelling study

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Katharine J Looker ◽  
Lesley A Wallace ◽  
Katherine ME Turner
Keyword(s):  
Cost Effectiveness ◽  
Mathematical Modelling ◽  
Chlamydia Testing ◽  
Modelling Study

scholarly journals The impact and cost-effectiveness of combined HIV prevention scenarios among transgender women sex-workers in Lima, Peru: a mathematical modelling study

2019 ◽  
Vol 4 (3) ◽  
pp. e127-e136 ◽  
Author(s):  
Annick Bórquez ◽  
Juan Vicente Guanira ◽  
Paul Revill ◽  
Patricia Caballero ◽  
Alfonso Silva-Santisteban ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Hiv Prevention ◽  
Mathematical Modelling ◽  
Sex Workers ◽  
Transgender Women ◽  
The Impact ◽  
Modelling Study

scholarly journals Potential impact of pre-exposure prophylaxis for female sex workers and men who have sex with men in Bangalore, India: a mathematical modelling study

2016 ◽  
Vol 19 (1) ◽  
pp. 20942 ◽  
Author(s):  
Kate M Mitchell ◽  
Holly J Prudden ◽  
Reynold Washington ◽  
Shajy Isac ◽  
Subramanian P Rajaram ◽  
...  
Keyword(s):  
Mathematical Modelling ◽  
Sex Workers ◽  
Female Sex Workers ◽  
Female Sex ◽  
Potential Impact ◽  
Sex With Men ◽  
Exposure Prophylaxis ◽  
Modelling Study

scholarly journals Effects of naloxone distribution alone or in combination with addiction treatment with or without pre-exposure prophylaxis for HIV prevention in people who inject drugs: a cost-effectiveness modelling study

2017 ◽  
Vol 2 (3) ◽  
pp. e133-e140 ◽  
Author(s):  
Jennifer Uyei ◽  
David A Fiellin ◽  
Marianne Buchelli ◽  
Ramon Rodriguez-Santana ◽  
R Scott Braithwaite
Keyword(s):  
Cost Effectiveness ◽  
Hiv Prevention ◽  
Addiction Treatment ◽  
People Who Inject Drugs ◽  
Exposure Prophylaxis ◽  
Modelling Study

scholarly journals Antiretroviral Therapy and Pre-exposure Prophylaxis: Combined Impact on HIV Transmission and Drug Resistance in South Africa

2013 ◽  
Vol 208 (2) ◽  
pp. 224-234 ◽  
Author(s):  
Ume L. Abbas ◽  
Robert Glaubius ◽  
Anuj Mubayi ◽  
Gregory Hood ◽  
John W. Mellors
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Hiv Transmission ◽  
Exposure Prophylaxis ◽  
Combined Impact
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