Epidemiology and Clinical Outcomes of Adults with Acute Respiratory Failure in a Low-Income Country: A Prospective, Observational, Multicentre Cohort Study

2021 ◽  
Author(s):  
Arthur Kwizera ◽  
Daphne Kabatooro ◽  
cornelius sendagire ◽  
Jane Nakibuuka ◽  
Darius Owachi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Clinical Outcomes ◽  
Low Income ◽  
Income Country ◽  
Low Income Country ◽  
Multicentre Cohort Study ◽  
Multicentre Cohort

scholarly journals Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study)

2020 ◽  
Vol 26 (11) ◽  
pp. 1545-1553 ◽  
Author(s):  
Michele Bartoletti ◽  
Maddalena Giannella ◽  
Luigia Scudeller ◽  
Sara Tedeschi ◽  
Matteo Rinaldi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Failure ◽  
Prediction Model ◽  
Hospitalized Patients ◽  
Severe Respiratory Failure ◽  
Multicentre Cohort Study ◽  
Development And Validation ◽  
Multicentre Cohort

Effects of short inter-pregnancy interval on maternal and perinatal outcomes: A cohort study of pregnant women in a low-income country

2020 ◽  
Vol 23 (7) ◽  
pp. 928
Author(s):  
EO Ugwu ◽  
CC Onwuka ◽  
SN Obi ◽  
CI Onwuka ◽  
CC Dim ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Low Income ◽  
Perinatal Outcomes ◽  
Income Country ◽  
Low Income Country ◽  
Inter Pregnancy Interval

Clinical outcomes of children receiving ABO-incompatible versus ABO-compatible heart transplantation: a multicentre cohort study

2021 ◽  
Vol 5 (5) ◽  
pp. 341-349 ◽  
Author(s):  
Simon Urschel ◽  
Jean A Ballweg ◽  
Ryan S Cantor ◽  
Devin A Koehl ◽  
Zdenka Reinhardt ◽  
...  
Keyword(s):  
Cohort Study ◽  
Heart Transplantation ◽  
Clinical Outcomes ◽  
Multicentre Cohort Study ◽  
Multicentre Cohort

scholarly journals Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort study

Critical Care ◽  
2022 ◽  
Vol 26 (1) ◽  
Author(s):  
Mariano Esperatti ◽  
Marina Busico ◽  
Nora Angélica Fuentes ◽  
Adrian Gallardo ◽  
Javier Osatnik ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Failure ◽  
Hospital Mortality ◽  
Acute Respiratory Failure ◽  
Clinical Outcomes ◽  
Endotracheal Intubation ◽  
High Flow ◽  
Secondary Outcome ◽  
Prone Positioning ◽  
Multicenter Cohort Study

Abstract Background In patients with COVID-19-related acute respiratory failure (ARF), awake prone positioning (AW-PP) reduces the need for intubation in patients treated with high-flow nasal oxygen (HFNO). However, the effects of different exposure times on clinical outcomes remain unclear. We evaluated the effect of AW-PP on the risk of endotracheal intubation and in-hospital mortality in patients with COVID-19-related ARF treated with HFNO and analyzed the effects of different exposure times to AW-PP. Methods This multicenter prospective cohort study in six ICUs of 6 centers in Argentine consecutively included patients > 18 years of age with confirmed COVID-19-related ARF requiring HFNO from June 2020 to January 2021. In the primary analysis, the main exposure was awake prone positioning for at least 6 h/day, compared to non-prone positioning (NON-PP). In the sensitivity analysis, exposure was based on the number of hours receiving AW-PP. Inverse probability weighting–propensity score (IPW-PS) was used to adjust the conditional probability of treatment assignment. The primary outcome was endotracheal intubation (ETI); and the secondary outcome was hospital mortality. Results During the study period, 580 patients were screened and 335 were included; 187 (56%) tolerated AW-PP for [median (p25–75)] 12 (9–16) h/day and 148 (44%) served as controls. The IPW–propensity analysis showed standardized differences < 0.1 in all the variables assessed. After adjusting for other confounders, the OR (95% CI) for ETI in the AW-PP group was 0.36 (0.2–0.7), with a progressive reduction in OR as the exposure to AW-PP increased. The adjusted OR (95% CI) for hospital mortality in the AW-PP group ≥ 6 h/day was 0.47 (0.19–1.31). The exposure to prone positioning ≥ 8 h/d resulted in a further reduction in OR [0.37 (0.17–0.8)]. Conclusion In the study population, AW-PP for ≥ 6 h/day reduced the risk of endotracheal intubation, and exposure ≥ 8 h/d reduced the risk of hospital mortality.

scholarly journals Age differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multicentre cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e039887 ◽  
Author(s):  
Huanyuan Luo ◽  
Songqiao Liu ◽  
Yuancheng Wang ◽  
Penelope A Phillips-Howard ◽  
Shenghong Ju ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Respiratory Failure ◽  
Hospital Stay ◽  
Older Patients ◽  
Adverse Outcomes ◽  
Trend Test ◽  
Chronic Obstructive ◽  
Multicentre Cohort Study ◽  
Multicentre Cohort

ObjectivesTo determine the age-specific clinical presentations and incidence of adverse outcomes among patients with COVID-19 in Jiangsu, China.Design and settingRetrospective, multicentre cohort study performed at 24 hospitals in Jiangsu, China.Participants625 patients with COVID-19 enrolled between 10 January and 15 March 2020.ResultsOf the 625 patients (median age, 46 years; 329 (52.6%) men), 37 (5.9%) were children (18 years or younger), 261 (41.8%) young adults (19–44 years), 248 (39.7%) middle-aged adults (45–64 years) and 79 (12.6%) elderly adults (65 years or older). The incidence of hypertension, coronary heart disease, chronic obstructive pulmonary disease and diabetes comorbidities increased with age (trend test, p<0.0001, p=0.0003, p<0.0001 and p<0.0001, respectively). Fever, cough and shortness of breath occurred more commonly among older patients, especially the elderly, compared with children (χ2 test, p=0.0008, 0.0146 and 0.0282, respectively). The quadrant score and pulmonary opacity score increased with age (trend test, both p<0.0001). Older patients had many significantly different laboratory parameters from younger patients. Elderly patients had the highest proportion of severe or critically-ill cases (33.0%, χ2 test p<0.0001), intensive care unit use (35.4%, χ2 test p<0.0001), respiratory failure (31.6%, χ2 test p<0.0001) and the longest hospital stay (median 21 days, Kruskal–Wallis test p<0.0001).ConclusionsElderly (≥65 years) patients with COVID-19 had the highest risk of severe or critical illness, intensive care use, respiratory failure and the longest hospital stay, which may be due partly to their having a higher incidence of comorbidities and poor immune responses to COVID-19.

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