scholarly journals Role of Respiratory Muscle Strength using MIP Testing Following COVID-19 Infection

2020 ◽  
Author(s):  
Anita Agrawal ◽  
Vivek Nalgirkar
Keyword(s):  
Muscle Strength ◽  
Respiratory Muscle ◽  
Muscular Atrophy ◽  
Muscle Performance ◽  
Inspiratory Pressure ◽  
Respiratory Muscle Strength ◽  
Maximal Inspiratory Pressure ◽  
Increased Risk ◽  
Muscle Impairment

Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) are measures of respiratory muscle strength and may be more sensitive in detecting early respiratory muscle impairment compared with spirometry. Respiratory muscle strength is a proven conjecturer of many diseases like muscular dystrophy, neuromuscular disease, amyotrophic lateral sclerosis and spinal muscular atrophy. Maximal inspiratory pressure is gaining interest as a test to improvise impaired respiratory muscle strength of COVID-19 patients following infection. The primary aim of this study is to discuss the potential role of respiratory muscle performance followed by coronavirus infection. The sensitivity and specificity of MIP and MEP was estimated on patients suffering with chronic lung disease. This study proposes a hypothesis that aims to screen for respiratory muscle impairment in patients with dyspnea or characteristics associated with increased risk of severe respiratory complaints.

scholarly journals Natural History of Respiratory Muscle Strength in Spinal Muscular Atrophy: A Prospective National Cohort Study

2021 ◽  
Author(s):  
Esther S Veldhoen ◽  
Camiel A Wijngaarde ◽  
Erik H.J. Hulzebos ◽  
Roelie W Wosten-van Asperen ◽  
Renske I Wadman ◽  
...  
Keyword(s):  
Early Childhood ◽  
Muscle Strength ◽  
Natural History ◽  
Spinal Muscular Atrophy ◽  
Respiratory Muscle ◽  
Muscular Atrophy ◽  
Inspiratory Pressure ◽  
Respiratory Muscle Strength ◽  
Treatment Naïve ◽  
National Cohort

Abstract Background: Respiratory complications are the most important cause of morbidity and mortality in Spinal Muscular Atrophy (SMA). Respiratory muscle weakness results in impaired cough, recurrent respiratory tract infections and finally respiratory failure. We assessed longitudinal patterns of measurements of respiratory muscle strength in a national cohort of treatment-naïve children and adults with SMA, hypothesizing a continued decline of respiratory muscle strength parameters throughout life. Methods: We measured Maximal Expiratory and Inspiratory Pressure (PEmax and PImax), Sniff Nasal Inspiratory Pressure (SNIP), Peak Expiratory Flow (PEF), and Peak Cough Flow (PCF) in treatment-naïve patients. We used both cross-sectional and longitudinal data in mixed-models to analyze natural history patterns. Results: We included 2756 measurements of respiratory muscle function from 80 treatment-naïve patients with SMA types 1c-3b. Both PEmax and PImax were significantly lower in more severe phenotypes. SNIP was low in nearly all patients, most pronounced in more severely affected patients. PEmax was low from early childhood onwards in patients with SMA type 1c–3a. PEF decline below 80% of predicted values was observed in early childhood in SMA types 1c-2 and in adolescence in patients with type 3a. Annual decline was linear (1-2%/year). All but type 3b patients had lowered PCF. Patients with types 2b and 3a had PCF levels between 160 and 270L/min, those with type 2a around 160L/min and patients with type 1c well below 160L/min. Conclusions: There are clear differences in respiratory muscle strength and its progressive decline between SMA types. We observed lower outcomes in more severe SMA types. Particularly PEmax and PEF may be suitable outcome measures for follow-up of patients with SMA. PEmax had the highest discriminative capacity and PEF declined in a rather linear pattern in all SMA types. PEmax was even low in patients with normal lung volumes. These natural history data may serve as a reference for longer-term treatment efficacy assessments.

scholarly journals Evaluation of Respiratory Muscle Strength in the Acute Phase of Stroke: The Role of Aging and Anthropometric Variables

2017 ◽  
Vol 26 (10) ◽  
pp. 2300-2305 ◽  
Author(s):  
Gustavo José Luvizutto ◽  
Maria Regina Lopes dos Santos ◽  
Lorena Cristina Alvarez Sartor ◽  
Josiela Cristina da Silva Rodrigues ◽  
Rafael Dalle Molle da Costa ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Acute Phase ◽  
Respiratory Muscle ◽  
Respiratory Muscle Strength

Longitudinal course of lung function and respiratory muscle strength in spinal muscular atrophy type 2 and 3

2013 ◽  
Vol 17 (6) ◽  
pp. 552-560 ◽  
Author(s):  
Sonia Khirani ◽  
Marina Colella ◽  
Valeria Caldarelli ◽  
Guillaume Aubertin ◽  
Michèle Boulé ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Lung Function ◽  
Spinal Muscular Atrophy ◽  
Respiratory Muscle ◽  
Muscular Atrophy ◽  
Respiratory Muscle Strength ◽  
Spinal Muscular Atrophy Type ◽  
Longitudinal Course

scholarly journals Respiratory Muscle Performance and the Perception of Dyspnea in Parkinson's Disease

2002 ◽  
Vol 29 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Paltiel Weiner ◽  
Rivka Inzelberg ◽  
Avi Davidovich ◽  
Puiu Nisipeanu ◽  
Rasmi Magadle ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Respiratory Muscles ◽  
Normal Subjects ◽  
Forced Expiratory Volume ◽  
Muscle Performance ◽  
Respiratory Muscle Strength ◽  
Before And After

Background:Pulmonary and respiratory muscle function impairment are common in patients with Parkinson's disease (PD). However, dyspnea is not a frequent complaint among these patients, although it is well documented that the intensity of dyspnea is related to the activity and the strength of the respiratory muscles.Patients and Methods:We studied pulmonary function, respiratory muscle strength and endurance and the perception of dyspnea (POD) in 20 patients with PD (stage II and III Hoehn and Yahr scale) before and after their first daily L-dopa dose. Respiratory muscle strength was assessed by measuring the maximal inspiratory and expiratory mouth pressures (PImax and PEmax), at residual volume (RV) and total lung capacity (TLC) respectively. The POD was measured while the subject breathed against progressive load and dyspnea was rated using a visual analog scale.Results:Respiratory muscle strength and endurance were decreased and the POD was increased during the off medication period compared to normal subjects. There was a nonsignificant trend to an increase in PImax, PEmax and endurance after L-dopa intake. The POD of PD patients decreased (p<0.05) following medication, although, it remained increased (p<0.01) as compared to the normal subjects. Even if patients had spirometry data showing a mild restrictive pattern, before medication, both forced vital capacity (FVC) and forced expiratory volume (FEV)1 remained almost identical after L-dopa intake.Conclusions:Patients with PD have higher POD, compared to normal subjects and this increased perception is attenuated when the patients are on dopaminergic medication. The change in the POD is not related to changes in respiratory muscle performance or pulmonary functions. A central effect or a correction of uncoordinated respiratory movements by L-dopa may contribute to the decrease in POD following L-dopa treatment.

scholarly journals Does obesity affect the respiratory muscle strength? An observational study

2021 ◽  
Vol 8 (4) ◽  
pp. 1880
Author(s):  
Isha Shripad ◽  
Razia Nagarwala
Keyword(s):  
Waist Circumference ◽  
Muscle Strength ◽  
Respiratory Muscle ◽  
Breathing Pattern ◽  
The Body ◽  
Physical Aspect ◽  
Obese Patients ◽  
Respiratory Muscle Strength ◽  
Inclusion Criteria ◽  
Maximal Inspiratory Pressure

Background: Obesity is a condition where the energy intake exceeds energy expenditure of the body. Obesity is seen to affect different aspects of life both physically and emotionally. One such physical aspect is the breathing pattern. Studies on the behavior of respiratory muscle strength (RMS) in obese patients have found conflicting results.Methods: Using purposive sampling, 60 subjects who fulfilled the inclusion criteria were recruited in the study. Each individual was subjected for the assessment of Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP), Body Mass Index (BMI) and Waist circumference (WC).   Results: A Pearson’s product-moment correlation coefficient showed a positive correlation between MIP and WC (r=0.378, n=60, p=0.003 with α at 0.01) and between MEP and WC (r=0.288, n=60, p=0.026 with α at 0.05). There was no correlation found between BMI and MIP (r=0.138, n=60, p=0.292) and BMI and MEP (r=0.150, n=60, p=0.252).Conclusions: The findings of the study suggest that the respiratory muscle strength is more in individuals with higher waist circumference values whereas with BMI it is inconclusive. 

scholarly journals Influence of heat and moisture exchanger use on measurements performed with manovacuometer and respirometer in healthy adults

2015 ◽  
Vol 11 ◽  
Author(s):  
Jeanette Janaina Jaber Lucato ◽  
Thiago Marraccini Nogueira da Cunha ◽  
Sara Solange Oliveira Costa Rocha ◽  
Fernanda Maria Palmieri de Carvalho ◽  
Daniele Cristina Botega ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Respiratory Muscle ◽  
Vital Capacity ◽  
Pulmonary Infection ◽  
Healthy Adults ◽  
Respiratory Muscle Strength ◽  
Maximal Inspiratory Pressure ◽  
Moisture Exchanger ◽  
Significant Difference ◽  
Heat And Moisture

Background: The use of evaluation tools such as the manovacuometer and respirometer is frequent and disinfection is usually limited to the external surfaces, which is insufficient and raises concerns because of the potential spread of infectious diseases. Hydrophobic heat and moisture exchangers (HME) are used in mechanical ventilation and have microbiological filters, which can possibly reduce contamination, increasing the safety of related procedures. It is unknown, however, if the addition of an exchanger affects the measurements obtained. Aim of this study was to verify if the use of an HME interferes in maximal inspiratory and expiratory pressures assessed using the manovacuometer and vital capacity evaluated using the respirometer in healthy adults. Methods: A controlled transversal trial was carried out. Twenty healthy young adults were included in the study. Vital capacity by respirometer and, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) were assessed with and without the use of HME. Results: No significant difference was found between the values pre and post HME use in vital capacity measurements: (3878.8 ± 202.2 mL vs. 3925.5 ± 206.0 mL, p = 0.116) and the respiratory muscle strength measurements: MIP (−99.0 ± 8.9 vs −95.5 ± 9.0 cm H2O, p = 0.149) and MEP (92.5 ± 7.5 vs 92.5 ± 7.7 cm H2O, p = 1.0) respectively. Conclusion: We conclude that the use of HME does not modify the lung volumes or respiratory muscle strength, and can be used in order to reduce the occurrence of pulmonary infection.

scholarly journals Effect of inspiratory muscle loaded exercise training on peak oxygen uptake and ventilatory response during incremental exercise under normoxia and hypoxia

2019 ◽  
Author(s):  
Takeshi Ogawa ◽  
Maiko Nagao ◽  
Naoto Fujii ◽  
Takeshi NIshiyasu
Keyword(s):  
Muscle Strength ◽  
Exercise Training ◽  
Exercise Performance ◽  
Respiratory Muscle ◽  
Work Capacity ◽  
Peak Oxygen Uptake ◽  
Inspiratory Muscle ◽  
Respiratory Muscle Strength ◽  
Maximal Inspiratory Pressure ◽  
Muscle Training

Abstract Background: Although numerous studies have reported the effect of inspiratory muscle training for improving exercise performance, the outcome of whether exercise performance is improved by inspiratory muscle training is controversial. Therefore, this study investigated the influence of inspiratory muscle-loaded exercise training (IMLET) on peak oxygen uptake (VO2peak), respiratory responses, and exercise performance under normoxic (N) and hypoxic (H) exercise conditions. We hypothesised that IMLET enhances respiratory muscle strength and improves respiratory response, thereby improving VO2peak and work capacity under H condition. Methods: Sixteen university track runners (13 men and 3 women) were randomly assigned to the IMLET (n=8) or exercise training (ET) group (n=8). All subjects underwent 4 weeks of 20-min 60% VO2peak cycling exercise training, thrice per week. IMLET loaded 50% of maximal inspiratory pressure during exercise. At pre- and post-training periods, subjects performed exhaustive incremental cycling under normoxic (N; 20.9 ± 0%) and hypoxic (H; 15.0 ± 0.1%) conditions. Results: Although maximal inspiratory pressure (PImax) significantly increased after training in both groups, the extent of PImax increase was significantly higher in the IMLET group (from 102 ± 20 to 145 ± 26 cmH2O in IMLET; from 111± 23 to 127 ± 23 cmH2O in ET; P < 0.05). In both groups, VO2peak and maximal work load (Wmax) similarly increased both under N and H conditions after training (P < 0.05). Further, the extent of Wmax decrease under H condition was lower in the IMLET group at post-training test than at pre-training (from -14.7 ± 2.2% to -12.5 ± 1.7%; P < 0.05). Maximal minute ventilation in both N and H conditions increased after training than in the pre-training period. Conclusions: Our IMLET enhanced the respiratory muscle strength, and the decrease in work capacity under hypoxia was reduced regardless of the increase VO2peak.

scholarly journals Effect of inspiratory muscle-loaded exercise training on peak oxygen uptake and ventilatory response during incremental exercise under normoxia and hypoxia 

2020 ◽  
Author(s):  
Takeshi Ogawa ◽  
Maiko Nagao ◽  
Naoto Fujii ◽  
Takeshi NIshiyasu
Keyword(s):  
Muscle Strength ◽  
Exercise Training ◽  
Exercise Performance ◽  
Respiratory Muscle ◽  
Work Capacity ◽  
Peak Oxygen Uptake ◽  
Inspiratory Muscle ◽  
Respiratory Muscle Strength ◽  
Maximal Inspiratory Pressure ◽  
Muscle Training

Abstract Background: Although numerous studies have reported the effect of inspiratory muscle training for improving exercise performance, the outcome of whether exercise performance is improved by inspiratory muscle training is controversial. Therefore, this study investigated the influence of inspiratory muscle-loaded exercise training (IMLET) on peak oxygen uptake (VO2peak), respiratory responses, and exercise performance under normoxic (N) and hypoxic (H) exercise conditions. We hypothesised that IMLET enhances respiratory muscle strength and improves respiratory response, thereby improving VO2peak and work capacity under H condition.Methods: Sixteen university track runners (13 men and 3 women) were randomly assigned to the IMLET (n=8) or exercise training (ET) group (n=8). All subjects underwent 4 weeks of 20-min 60% VO2peak cycling exercise training, thrice per week. IMLET loaded 50% of maximal inspiratory pressure during exercise. At pre- and post-training periods, subjects performed exhaustive incremental cycling under normoxic (N; 20.9 ± 0%) and hypoxic (H; 15.0 ± 0.1%) conditions. Results: Although maximal inspiratory pressure (PImax) significantly increased after training in both groups, the extent of PImax increase was significantly higher in the IMLET group (from 102 ± 20 to 145 ± 26 cmH2O in IMLET; from 111 ± 23 to 127 ± 23 cmH2O in ET; P<0.05). In both groups, VO2peak and maximal work load (Wmax) similarly increased both under N and H conditions after training (P<0.05). Further, the extent of Wmax decrease under H condition was lower in the IMLET group at post-training test than at pre-training (from -14.7 ± 2.2% to -12.5 ± 1.7%; P<0.05). Maximal minute ventilation in both N and H conditions increased after training than in the pre-training period. Conclusions: Our IMLET enhanced the respiratory muscle strength, and the decrease in work capacity under hypoxia was reduced regardless of the increase in VO2peak.

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