scholarly journals Low periostin expression predicts poor survival in intestinal type gastric cancer patients

2018 ◽  
Vol Volume 11 ◽  
pp. 25-36 ◽  
Author(s):  
Teming Zhang ◽  
Zheng Han ◽  
Arvine Chandoo ◽  
Xincheng Huang ◽  
Xiangwei Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Intestinal Type ◽  
Poor Survival ◽  
Gastric Cancer Patients

Low Serum Albumin Correlates with Poor Survival in Gastric Cancer Patients

2018 ◽  
Vol 64 (03/2018) ◽  
Author(s):  
Xiaojuan Ouyang ◽  
Yuan Dang ◽  
Fan Zhang ◽  
Qiaojia Huang
Keyword(s):  
Gastric Cancer ◽  
Serum Albumin ◽  
Cancer Patients ◽  
Poor Survival ◽  
Gastric Cancer Patients ◽  
Low Serum

The relationship between HER-2 and TOPO-2A gene expression and clinicopathologic results in gastric cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14670-e14670
Author(s):  
Metin Ozkan ◽  
Esra Ermis Turak ◽  
Halit Karaca ◽  
Mevlude Inanc ◽  
Veli Berk ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Median Overall Survival ◽  
Intestinal Type ◽  
Negative Group ◽  
Diffuse Type ◽  
Her 2 ◽  
Gastric Cancer Patients

e14670 Background: HER-2 and Topo-2A genes are settled on a chromosome 17 and their co-amplification rates are high. In this study, early gastric cancer patients who received adjuvant chemo-radiotherapy and chemotherapy were evaluated with HER-2 and Topo-2A expression in association with clinical and histopathologic findings. Methods: A total of 103 gastric cancer patients were included the study. The HER-2 and Topo-2A levels were measured by immunohistochemistry in postoperative tumor materials. A standard evaluation method was admitted for HER-2 positivity, while Topo-2A nuclear staining 3+ and 4+ were considered as overexpression. Those with level 2+ or 3+ of HER-2, the FISH test were attempted. Results: The median follow-up was 19 months (ranges 2–70 months). Forty-six patients (44%) relapsed during follow-up whereas 60 patients (58%) had died. The median overall survival (mOS) was 23 months. Histopathologies of HER-2 positive patients were intestinal type in 7 (87.5%) and diffuse type in one (12.5%) patient. In the follow-up period 4 patients (50%) were died (mOS was 17 months in this group). Median overall survival was 23 months in HER-2 negative group (p=0.6). Histopathologies of Topo-2A positive patients were intestinal type in 9 (64.2%) and diffuse type in 5 (35.8%) patient. In the follow-up period 8 patients (57%) were died (mOS was 22 months in this group). Median overall survival was 23 months in Topo-2A negative group (p=0.8). Three patients (37.5%) who had HER-2 positive histopathologies also had Topo-2A positivity. Conclusions: Overexpression rates of HER-2 in gastric cancer were reported 6.8-34%. Racial differences and different scoring techniques thought to be impact the results. Co-amplification rate of HER-2 and Topo-2A was reported 34% in gastric cancer. In our study HER-2 and Topo-2A overexpression rates were 7.7% and 13.6% respectively and co-amplification of HER-2 with Topo-2A rate was 37.5% is also similar to the other studies. Stages of patients with HER-2 and Topo-2A overexpression were similar to the distribution of the overall patients. While intestinal subtypes showed a higher rate of HER-2 overexpression, the median survival times tend to be shorter in HER-2 positive patients.

scholarly journals Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients

Oncotarget ◽  
2017 ◽  
Vol 8 (12) ◽  
pp. 18848-18860 ◽  
Author(s):  
Shu Zhang ◽  
Shuling Huang ◽  
Chao Deng ◽  
Yu Cao ◽  
Jun Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
Gastric Cancer Patients

scholarly journals Decreased albumin-to-alkaline phosphatase ratio predicted poor survival of resectable gastric cancer patients

2021 ◽  
Vol 12 (4) ◽  
pp. 1338-1350
Author(s):  
Yan Wang ◽  
Feng Xiong ◽  
Jian Yang ◽  
Tingting Xia ◽  
Zhenyu Jia ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Alkaline Phosphatase ◽  
Cancer Patients ◽  
Poor Survival ◽  
Resectable Gastric Cancer ◽  
Gastric Cancer Patients

scholarly journals Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients

2019 ◽  
Vol Volume 12 ◽  
pp. 5589-5599
Author(s):  
Yanyan Shi ◽  
Siliang Zhou ◽  
Pan Wang ◽  
Yanlei Guo ◽  
Bingteng Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Malic Enzyme ◽  
Poor Survival ◽  
Gastric Cancer Cells ◽  
Gastric Cancer Patients

Prognostic effect of high pretreatment neutrophil to lymphocyte ratio on survival of patients with gastric adenocarcinoma in China

2015 ◽  
Vol 30 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Miaozhen Qiu ◽  
Yixin Zhou ◽  
Ying Jin ◽  
Xiao-li Wei ◽  
De-shen Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Gastric Adenocarcinoma ◽  
Prognostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Healthy Individuals ◽  
Poor Survival ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Gastric Cancer Patients

Background A high neutrophil to lymphocyte ratio (NLR) is a strong predictor of poor survival in patients with colorectal, breast, pancreatic and lung cancers, while the prognostic value of NLR in gastric cancer is still controversial. The aim of our study was to determine the prognostic value of pretreatment NLR in a Chinese population of patients with gastric adenocarcinoma. Methods Our retrospective study used an unselected cohort of gastric adenocarcinoma patients treated in the Cancer Center of Sun Yat-sen University between January 2001 and December 2008. We used the data from 341 healthy individuals as controls to understand the difference of NLR between the gastric cancer patients and normal individuals. A total of 706 patients had a complete blood count (CBC) record prior to treatment. Cox regression analysis was used to evaluate the prognostic value of NLR. Results Gastric adenocarcinoma patients had a significantly higher NLR as well as neutrophilic granulocyte and lower lymphocyte counts compared with healthy individuals. By combining the nearby groups of NLR whose survival had no significant difference, we got a cutoff value for NLR of 3. Patients with a high NLR had a significantly lower survival rate than patients with a low NLR. On multivariate analysis, after adjusting for tumor stage and other clinicopathologic factors, high NLR turned out to be an independent risk factor for poor survival (p=0.016). Conclusions Gastric cancer patients had a significantly higher incidence rate of high NLR compared with healthy individuals. High pretreatment NLR in gastric cancer was an independent prognostic factor.

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