Low Serum Albumin Correlates with Poor Survival in Gastric Cancer Patients

2018 ◽  
Vol 64 (03/2018) ◽  
Author(s):  
Xiaojuan Ouyang ◽  
Yuan Dang ◽  
Fan Zhang ◽  
Qiaojia Huang
Keyword(s):  
Gastric Cancer ◽  
Serum Albumin ◽  
Cancer Patients ◽  
Poor Survival ◽  
Gastric Cancer Patients ◽  
Low Serum

scholarly journals Low periostin expression predicts poor survival in intestinal type gastric cancer patients

2018 ◽  
Vol Volume 11 ◽  
pp. 25-36 ◽  
Author(s):  
Teming Zhang ◽  
Zheng Han ◽  
Arvine Chandoo ◽  
Xincheng Huang ◽  
Xiangwei Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Intestinal Type ◽  
Poor Survival ◽  
Gastric Cancer Patients

Prognostic value of baseline complete blood count components in advanced gastric cancer patients: A multicenter retrospective study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16528-e16528
Author(s):  
Shereef Ahmed Elsamany ◽  
Ahmed Zeeneldin ◽  
Emad Tashkandi ◽  
Ayman Ahamd Rasmy ◽  
Waleed Abozeed ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multivariate Analysis ◽  
Serum Albumin ◽  
Cancer Patients ◽  
Eosinophil Count ◽  
Univariate Analysis ◽  
Metastatic Gastric Cancer ◽  
Neutrophil Percentage ◽  
Gastric Cancer Patients ◽  
Doublet Chemotherapy

e16528 Background: Gastric cancer (GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. Pretreatment CBC-based biomarkers, including blood neutrophil, lymphocyte, monocyte, and platelet counts; hemoglobin (Hb) levels; and their combinations, such as the neutrophil-lymphocyte ratio(NLR), lymphocyte-monocyte ratio (LMR) and platelet-lymphocyte ratio (PLR), have been reported to reflect systemic and local inflammation associated with cancer progression and prognosis. There has been growing interest in using CBC-based measures as biomarkers for GC. Methods: This chart-review study aimed to evaluate the effect of baseline levels of different components of routine CBC examination as well as other patients and disease characteristics on progression free survival (PFS) and overall survival (OS) in metastatic gastric cancer patients. Total 135 metastatic gastric cancer patients who had diagnosed and treated in three oncology centers in Saudi Arabia from 2011 to 2016 were incorporated. Various potential prognostic factors had measured in univariate and multivariate analysis. Results: After a median follow up of 21.4 months, the median OS / PFS were 11.0 and 6.1 months, respectively. Higher albumin level ( > 3g/dl), low neutrophil percentage ≤ 75%, high lymphocyte percentage > 15%, neutrophil /lymphocyte ≤ 2.5, high eosinophil count > 0.4 k/ml, and EOX/EOF chemotherapy vs. doublet chemotherapy were associated with better PFS in univariate analysis. Conversely, in multivariate analysis, only serum albumin and eosinophil levels were related to PFS. In univariate analysis, higher serum albumin (3 g/dl), low neutrophil percentage ≤ 75%, high lymphocyte percentage > 15%, neutrophil/lymphocyte ≤2.5, high eosinophil count > 0.4 k/ml, receiving 1st line chemotherapy vs. no chemotherapy, receiving > 6 cycles of chemotherapy, receiving EOX/EOF chemotherapy vs. doublet chemotherapy, platelet count ≤450 k/ml, male gender were associated with better OS. In multivariate analysis, lower neutrophil percentage, higher serum albumin, male sex and higher number of chemotherapy cycles were independently associated with OS. Conclusions: Higher eosinophil level was associated with improved PFS while lower neutrophil percentage and higher number of chemotherapy cycles were independent predictors of OS. Higher albumin levels independently predicted better OS and PFS.

scholarly journals Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients

Oncotarget ◽  
2017 ◽  
Vol 8 (12) ◽  
pp. 18848-18860 ◽  
Author(s):  
Shu Zhang ◽  
Shuling Huang ◽  
Chao Deng ◽  
Yu Cao ◽  
Jun Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
Gastric Cancer Patients

scholarly journals Decreased albumin-to-alkaline phosphatase ratio predicted poor survival of resectable gastric cancer patients

2021 ◽  
Vol 12 (4) ◽  
pp. 1338-1350
Author(s):  
Yan Wang ◽  
Feng Xiong ◽  
Jian Yang ◽  
Tingting Xia ◽  
Zhenyu Jia ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Alkaline Phosphatase ◽  
Cancer Patients ◽  
Poor Survival ◽  
Resectable Gastric Cancer ◽  
Gastric Cancer Patients

scholarly journals Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients

2019 ◽  
Vol Volume 12 ◽  
pp. 5589-5599
Author(s):  
Yanyan Shi ◽  
Siliang Zhou ◽  
Pan Wang ◽  
Yanlei Guo ◽  
Bingteng Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Malic Enzyme ◽  
Poor Survival ◽  
Gastric Cancer Cells ◽  
Gastric Cancer Patients

Ảnh hưởng của một số đặc điểm lâm sàng, cận lâm sàng lên sống còn toàn bộ bệnh nhân ung thư dạ dày giai đoạn tiến xa

2021 ◽  
Author(s):  
Hong Chuyen Nguyen-Thi
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Serum Albumin ◽  
Cancer Patients ◽  
Tumor Location ◽  
Albumin Level ◽  
Nodal Metastasis ◽  
Rank Test ◽  
Advanced Stage ◽  
Gastric Cancer Patients

TÓM TẮT Mục tiêu: Khảo sát ảnh hưởng của một số đặc điểm lâm sàng và cận lâm sàng lên sống còn toàn bộ của bệnh nhân ung thư dạ dày giai đoạn tiến xa. Phương pháp: Nghiên cứu mô tả loạt ca, hồi cứu trên 167 bệnh nhân ung thư dạ dày giai đoạn tiến xa được chẩn đoán và điều trị triệu chứng tại khoa Ung Bướu bệnh viện Trường Đại học Y Dược Huế và Trung tâm Ung Bướu Bệnh viện Trung Ương Huế từ tháng 01/2015 đến tháng 12/2020. Phân tích thời gian sống còn bằng mô hình Kaplan Meier và so sánh sự khác biệt về thời gian sống giữa các nhóm bệnh nhân theo đặc điểm lâm sàng, cận lâm sàng bằng Log rank test. Kết quả: Tuổi trung bình là 58,2; tỷ lệ nam/nữ là 2.5/1. Tại thời điểm chẩn đoán, đa số bệnh nhân có BMI là dưới 18,5 kg/m2 (64,1%) và KPS = 90% (50,3%). Triệu chứng lâm sàng phổ biến nhất là đau thượng vị (73,7%). Albumin máu < 35g/L chiếm 86,2%. Hầu hết bệnh nhân có tình trạng di căn xa (89,8%); 2,4% bệnh nhân có tình trạng huyết khối tĩnh mạch. Trung vị sống còn toàn bộ là 11 tháng. Phân tích đơn biến cho thấy các yếu tố ảnh hưởng đến sống còn toàn bộ là tuổi, chỉ số trạng thái hoạt động cơ thể Karnofsky (KPS), vị trí tổn thương, di căn hạch vùng, huyết khối tĩnh mạch, Albumin huyết thanh. Kết luận: Nghiên cứu cho thấy bệnh nhân ung thư dạ dày giai đoạn tiến xa có tiên lượng xấu với sống còn toàn bộ là 11 tháng. Các yếu tố lâm sàng gồm tuổi, chỉ số KPS, vị trí tổn thương, di căn hạch vùng, huyết khối tĩnh mạch ảnh hưởng đến sống còn toàn bộ bệnh nhân. ABSTRACT THE EFFECT OF SOME CLINICAL AND LABORATORY CHARACTERISTICS ON OVERALL SURVIVAL OF ADVANCED - STAGE GASTRIC CANCER PATIENTS Purposes: To investigate the influence of some clinical and laboratory characteristics on the overall survival of advanced - stage gastric cancer patients. Methods: A retrospective case series study with 167 early - stageadvanced - stage gastric cancer patients recruited from at oncology department, the Hospital of Hue University of Medicine and Pharmacy and Oncology Center of Hue Central HospitalfromJanuary 2015 to December 2020. The Kaplan - Meier method was used to estimate survival, the log - rank test analyzed the relevant factors. Results: Median age was 58.2; male/female was 2.5/1; the most common clinical symptom was epigastric pain (78.7%); at the time of diagnosis, almost all patients had KPS 90% (50.3%); BMI index below 18.5 (64.1%). Serum albumin < 35g/l accounting for 86.2% of patients. 89.8% of patients had distant metastasis disease. The median survival was 11 months. Univariate analysis indicated that age, KPS, primary tumor location, regional nodal metastasis, venous thrombosis, serum albumin level affecting on overall survival. Conclusions: Advanced - stage gastric cancer patients had poor survival with a median of 11 months. Age, KPS, tumor location, regional nodal metastasis, venous thrombosis, serum albumin level influence overall survival. Keywords: Outcomes, advanced - stage, gastric cancer.

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