Prognostic effect of high pretreatment neutrophil to lymphocyte ratio on survival of patients with gastric adenocarcinoma in China

2015 ◽  
Vol 30 (1) ◽  
pp. 96-103 ◽  
Author(s):  
Miaozhen Qiu ◽  
Yixin Zhou ◽  
Ying Jin ◽  
Xiao-li Wei ◽  
De-shen Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Gastric Adenocarcinoma ◽  
Prognostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Healthy Individuals ◽  
Poor Survival ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Gastric Cancer Patients

Background A high neutrophil to lymphocyte ratio (NLR) is a strong predictor of poor survival in patients with colorectal, breast, pancreatic and lung cancers, while the prognostic value of NLR in gastric cancer is still controversial. The aim of our study was to determine the prognostic value of pretreatment NLR in a Chinese population of patients with gastric adenocarcinoma. Methods Our retrospective study used an unselected cohort of gastric adenocarcinoma patients treated in the Cancer Center of Sun Yat-sen University between January 2001 and December 2008. We used the data from 341 healthy individuals as controls to understand the difference of NLR between the gastric cancer patients and normal individuals. A total of 706 patients had a complete blood count (CBC) record prior to treatment. Cox regression analysis was used to evaluate the prognostic value of NLR. Results Gastric adenocarcinoma patients had a significantly higher NLR as well as neutrophilic granulocyte and lower lymphocyte counts compared with healthy individuals. By combining the nearby groups of NLR whose survival had no significant difference, we got a cutoff value for NLR of 3. Patients with a high NLR had a significantly lower survival rate than patients with a low NLR. On multivariate analysis, after adjusting for tumor stage and other clinicopathologic factors, high NLR turned out to be an independent risk factor for poor survival (p=0.016). Conclusions Gastric cancer patients had a significantly higher incidence rate of high NLR compared with healthy individuals. High pretreatment NLR in gastric cancer was an independent prognostic factor.

scholarly journals Preoperative Neutrophil-to-lymphocyte Ratio May Predict Postoperative Pneumonia in Stage I–III Gastric Cancer Patients After Curative Gastrectomy: A Retrospective Study

2020 ◽  
Author(s):  
Mikito Mori ◽  
Kiyohiko Shuto ◽  
Atsushi Hirano ◽  
Kazuo Narushima ◽  
Chihiro Kosugi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Postoperative Complications ◽  
Cancer Patients ◽  
Neutrophil To Lymphocyte Ratio ◽  
Stage I ◽  
Postoperative Pneumonia ◽  
Prognostic Parameters ◽  
Curative Gastrectomy ◽  
Lymphocyte Ratio ◽  
Gastric Cancer Patients

Abstract Background: Several studies have demonstrated that diverse systemic inflammatory-based prognostic parameters predict poor prognosis in patients with gastric cancer. However, few studies focused on the relationships between postoperative complications and systemic inflammatory-based prognostic parameters after curative gastrectomy. We investigated the relationships between postoperative complications and these parameters to identify parameter-specific postoperative complications, and assessed the clinical utility of the parameters as predictors of postoperative complications in stage I–III gastric cancer patients.Methods: We retrospectively reviewed 300 patients who underwent curative gastrectomy for stage I–III gastric cancer. A postoperative complication sensitive to the systemic inflammatory-based prognostic parameters was identified using a receiver operating characteristic curve, and we evaluated the relationships between the identified postoperative complication and other clinical factors.Results: In total, 101 patients (33.7%) had postoperative Clavien–Dindo grade II–IV complications, namely anastomotic complications, such as leak, stenosis, or hemorrhage (35 patients, 11.7%); pancreatic fistula (16 patients, 5.3%); and pneumonia (14 patients, 4.7%). Postoperative pneumonia had the most sensitive relationship to five systemic inflammatory-based prognostic parameters, and was associated with poor prognosis in stage I–III gastric cancer patients after curative gastrectomy. Multivariate analysis revealed that preoperative neutrophil-to-lymphocyte ratio (odds ratio: 5.228, 95% confidence interval: 1.269–21.541; P=0.022) was an independent predictor of postoperative pneumonia.Conclusions: Preoperative neutrophil-to-lymphocyte ratio may be a useful predictor of postoperative pneumonia in stage I–III gastric cancer patients after curative gastrectomy.

scholarly journals The relationship between survival gastric cancer patients and neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio diagnosed before surgery

2020 ◽  
Author(s):  
Sareh Mohammadi ◽  
Zeinab Veisi ◽  
Mohammad Moazeni ◽  
Soleiman Kheiri ◽  
Zahra Lorigooini ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Cancer Patients ◽  
Patient Survival ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Gastric Cancer Patients ◽  
Relationship Of ◽  
The Relationship

Abstract Aim: This study aims to investigate the relationship of two prognostic factors NLR and PLR to patient survival in gastric cancer patients diagnosed before surgery.Background: Due to the high prevalence of gastric cancer and the lack of appropriate prognostic factors, most patients are diagnosed at advanced stages of the disease. Therefore, this study aimed to determine the appropriate prognostic factor investigated investigate the relationship of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in gastric cancer patients.Methods: This retrospective study was performed on all gastric cancer patients referred to Kashani Hospital of Shahrekord (Chaharmahal and Bakhtiari province) in 2011-2016. Demographic and biological variables such as NLR and PLR were evaluated. Patient survival was calculated by subtracting the date at disease diagnosis (using endoscopy) from the date at death and expressed in month. Data was analyzed by SPSS software.Results: The mean age of patients was 63.79 ± 15.03 (range: 10-92) years. 76% of patients were male and the rest were female. Only NLR had significant effect on survival (P < 0.05) and PLR had no significant effect on survival (P > 0.05).Conclusion: With the increase in NLR by one point, the risk of death in gastric cancer patients increased by 18%. In other words, with increase in NLR, survival rate of gastric cancer after surgery significantly decreased. It is suggested that further studies be conducted with a more statistical population to ensure the reproducibility of the results of the present study.

The neutrophil-to-lymphocyte ratio (NLR) predicts short-term and long-term outcomes in gastric cancer patients

2018 ◽  
Vol 44 (5) ◽  
pp. 607-612 ◽  
Author(s):  
Ryoichi Miyamoto ◽  
Satoshi Inagawa ◽  
Naoki Sano ◽  
Sosuke Tadano ◽  
Shinya Adachi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Neutrophil To Lymphocyte Ratio ◽  
Long Term Outcomes ◽  
Short Term ◽  
Lymphocyte Ratio ◽  
Gastric Cancer Patients

scholarly journals The Preoperative and the Postoperative Neutrophil-to-Lymphocyte Ratio Both Predict Prognosis in Gastric Cancer Patients

2020 ◽  
Author(s):  
Eun Young Kim ◽  
Kyo Young Song
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Characteristic Curve ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Impact ◽  
Curative Surgery ◽  
Lymphocyte Ratio ◽  
Postoperative Changes ◽  
Long Term Prognosis ◽  
Gastric Cancer Patients

Abstract Background: Both the preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR) have been proposed to predict the long-term prognosis in some cancers, including gastric cancer. The present study investigated the prognostic impact of postoperative NLR, and its preoperative to postoperative changes, in patients with gastric cancer. Methods: From 2009 to 2012, 1,612 consecutive patients who underwent curative surgery for gastric cancer were enrolled in this study. The optimal cut-off value for the postoperative 6-month NLR was 1.7, as determined by receiver operating characteristic curve analysis. Patients were categorized into low- and high-NLR groups based on their postoperative NLR. Four additional groups (low to low, low to high, high to low, and high to high groups) were defined based on the preoperative to postoperative change in the NLR.Results: The 5-year overall survival (OS) rates of the low- and high-NLR group were 90.7% and 83.0%, respectively (P < 0.001). The differences in OS were significant in stage I and stage III gastric cancer patients. (P = 0.000 and 0.012, respectively). Postoperative NLR was an independent prognostic factor for OS (hazard ratio [HR] = 1.611; P = 0.005). The high to high NLR change was a significant predictor of OS (HR = 1.914; P = 0.001). Conclusions: High preoperative and postoperative NLRs, and especially the persistent elevation of preoperative to postoperative NLR, were significant prognostic factors for OS in patients with gastric cancer.

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