Predictive Value of Preoperative Controlling Nutritional Status Score Combined with Fibrinogen–Albumin Ratio in Postoperative Local Recurrence-Free Survival of Patients with Retroperitoneal Liposarcoma

1120 Background: After breast conserving surgery, radiotherapy leads to a better overall survival. In addition to whole breast radiotherapy (WBRT) a boost to the tumor bed leads to a better local control. The tumor bed boost is usually added after WBRT or can be done intraoperative (IORT). Belletti et al. (Clin Cancer Res., 2008) described positive effects, an antitumoral effect and modulation of microenvironment after IORT with 50kV x-rays. A matched pair analysis was performed to investigate the impact of IORT boost on overall survival compared to standard external beam boost. Methods: Between 2002 – 2009, 370 patients were treated for breast cancer with WBRT + boost (external beam (EBRT) boost n = 146, IORT boost n =224). A matched pair analysis (1:1 propensity score matching for age, TNM, grading, hormonal treatment and chemotherapy) for overall survival and local recurrence free survival could be done for 53 pairs. All patients underwent breast conserving surgery and WBRT with 46-50Gy. 53 patients received an EBRT boost with 16Gy (2Gy/fraction, dedicated linear accelerator) and 53 patients received an IORT boost with 20Gy (INTRABEAM system, 50kV x-rays). Median follow-up was 6 months (range, 1-77 months) for the EBRT boost patients and 56 months (range, 2-97 months) for IORT boost patients. Kaplan Meier estimates were performed for overall survival and local recurrence free survival. Results: IORT boost patients had a longer follow-up than EBRT boost patients. Despite the difference in follow-up times, there was a strong trend towards better overall survival after IORT boost (90.2% vs. 62.3%, p = 0.375). One local recurrence was present in each group (EBRT boost after 15 months, local recurrence free survival 95%; IORT boost after 12 months, local recurrence free survival 98.1%). Conclusions: IORT given as a boost seems to have a positive impact on overall survival in breast cancer patients after breast conserving surgery. To identify such an effect a prospective randomized trial should be conducted.

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164 Preoperative radiation with concurrent chemotherapy for respectable rectal cancer: Does dose escalation improve local recurrence free survival and disease free survival?

Radiotherapy and Oncology ◽

10.1016/s0167-8140(04)80664-9 ◽

2004 ◽

Vol 72 ◽

pp. S50

Keyword(s):

Rectal Cancer ◽

Local Recurrence ◽

Dose Escalation ◽

Disease Free Survival ◽

Concurrent Chemotherapy ◽

Preoperative Radiation ◽

Recurrence Free Survival ◽

Free Survival ◽

Local Recurrence Free Survival ◽

Disease Free

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CT-Based Radiomics Nomogram may predict Local Recurrence-free Survival in Esophageal Squamous Cell Carcinoma Patients Receiving Definitive Chemoradiotherapy: A Multicenter Study

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2020.07.1799 ◽

2020 ◽

Vol 108 (3) ◽

pp. e587

Author(s):

L. Zhao ◽

W. Zhang ◽

J. Gong ◽

Y. Liao ◽

Y. Yin ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Local Recurrence ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Multicenter Study ◽

Recurrence Free Survival ◽

Definitive Chemoradiotherapy ◽

Free Survival ◽

Local Recurrence Free Survival

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Role of radiotherapy in adenoid cystic carcinoma of the head and neck

The Journal of Laryngology & Otology ◽

10.1017/s0022215109990338 ◽

2009 ◽

Vol 123 (10) ◽

pp. 1137-1144 ◽

Cited By ~ 41

Author(s):

T A Iseli ◽

L H Karnell ◽

S M Graham ◽

G F Funk ◽

J M Buatti ◽

...

Keyword(s):

Local Recurrence ◽

Adenoid Cystic Carcinoma ◽

Head And Neck ◽

Distant Metastases ◽

Recurrence Free Survival ◽

Free Survival ◽

Prognostic Features ◽

Adenoid Cystic ◽

Radiotherapy Alone ◽

Local Recurrence Free Survival

AbstractThis study retrospectively reviewed 183 cases of adenoid cystic carcinoma treated over 40 years. The local recurrence free survival rate was 68.2 per cent at five years and 40.8 per cent at 10 years. At 10 years, local recurrence free survival was significantly worse following radiotherapy alone (0 per cent), compared with surgery alone (41.8 per cent, p = 0.004) or combined with post-operative radiotherapy (43.5 per cent, p = 0.001). Neither tumour stage three or four, perineural invasion, solid subtype nor involved margins predicted local recurrence. Treatment with radiotherapy alone resulted in worse survival than surgery alone (p = 0.002) or combined with post-operative radiotherapy (p = 0.001). Survival rates following local recurrence (n = 34) were higher following surgery (p = 0.006) but not significantly improved following radiotherapy (p = 0.139). Chemotherapy for distant metastases did not prolong survival (p = 0.747) but did result in improved eating and aesthetics scores, while decreasing overall physical health. These results indicate that surgery is preferable for primary and recurrent adenoid cystic carcinoma of the head and neck. The incidence of local recurrence following surgery and postoperative radiotherapy was similar to surgery alone cases although the latter had less adverse prognostic features. Contemporary chemotherapy may benefit quality of life but not survival in patients with distant metastases due to adenoid cystic carcinoma of the head and neck.

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