Clinical Evolution and Quality of Life in Clinically Based COPD Chronic Bronchitic and Emphysematous Phenotypes: Results from the 1-Year Follow-Up of the STORICO Italian Observational Study

Objective: The aim of the study is to assess the therapeutic efficacy of drugs used in acne vulgaris by measuring the severity of acne using the Global Acne Grading System score (GAGS) and Cardiff Acne Disability Index (CADI) questionnaire score pre and post-drug therapy. Methods: The present study was conducted in the Department of Dermatology after getting approval from the Institutional Ethics Committee (No MC/190/2007/Pt1/MAR-2019/PG/123) dated 10/04/2019. It was an observational study for a period of 1 y. 172 patients were enrolled in the study. Patients were divided into 4 grades depending on their clinical manifestation. The severity of acne vulgaris and the quality of life were measured using the GAGS scale and the CADI questionnaire, respectively at the first visit and at the follow-up visit in all the grades of acne vulgaris. A correlation was done between the GAGS and the CADI score at the follow-up visit in all grades of acne. Results: It was observed that the GAGS score and the CADI score was significantly improved at the F/U visit (p<0.05) as compared to baseline in all the 4 grades of acne. A correlation between GAGS score and QoL using CADI scale was done using Pearson Parametric Correlation Test. In none of the groups, the correlation was significant (p>0.05). Conclusion: We can conclude from our study that following treatment with drugs, the clinical severity of acne decreased and there was also a significant improvement in the quality of life of patients.

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Clinical, radiological and functional outcomes in patients with SARS-CoV-2 pneumonia: a prospective observational study

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01509-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Pietro Gianella ◽

Elia Rigamonti ◽

Marco Marando ◽

Adriana Tamburello ◽

Lorenzo Grazioli Gauthier ◽

...

Keyword(s):

Quality Of Life ◽

Lung Function ◽

Observational Study ◽

Ct Scan ◽

Prospective Observational Study ◽

Lung Function Tests ◽

Medium Term ◽

Function Tests

Abstract Background All over the world, SARS-CoV-2 pneumonia is causing a significant short-term morbidity and mortality, but the medium-term impact on lung function and quality of life of affected patients are still unknown. Methods In this prospective observational study, 39 patients with SARS-CoV-2 pneumonia were recruited from a single COVID-19 hospital in Southern Switzerland. At three months patients underwent radiological and functional follow-up through CT scan, lung function tests, and 6 min walking test. Furthermore, quality of life was assessed through self-reported questionnaires. Results Among 39 patients with SARS-CoV-2 pneumonia, 32 (82% of all participants) presented abnormalities in CT scan and 25 (64.1%) had lung function tests impairment at three months. Moreover, 31 patients (79.5%) reported a perception of poor health due to respiratory symptoms and all 39 patients showed an overall decreased quality of life. Conclusions Medium-term follow up at three months of patients diagnosed with SARS-CoV-2 pneumonia shows the persistence of abnormalities in CT scans, a significant functional impairment assessed by lung function tests and a decreased quality of life in affected patients. Further studies evaluating the long-term impact are warranted to guarantee an appropriate follow-up to patients recovering from SARS-CoV-2 pneumonia.

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Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review

10.21203/rs.3.rs-60935/v1 ◽

2020 ◽

Author(s):

Muhammad Maarj ◽

Andrea Coda ◽

Louise Tofts ◽

Cylie Williams ◽

Derek Santos ◽

...

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Outcome Measures ◽

Joint Hypermobility ◽

Assessment Tools ◽

Post Intervention ◽

Associated Symptoms ◽

Prospective Longitudinal

Abstract Background This study aimed to synthesise outcome measure type and use in interventional or prospective longitudinal studies of children with generalised joint hypermobility (GJH) and associated symptoms. Method Electronic searches of Medline, CINAHL and Embase databases from inception to 16th March 2020 were performed for studies of children with GJH and symptoms between 5-18 years reporting repeated outcome measures collected at least 4 weeks apart. Methodological quality of eligible studies were described using the Downs and Black checklist.Results Six studies comprising of five interventional, and one prospective observational study (total of 388 children) met the inclusion criteria. Interventional study durations were between 2 to 3 months, with up to 10 months post-intervention follow-up, while the observational study spanned 3 years. Three main constructs of pain, function and quality of life were reported as primary outcome measures using 20 different instruments. All but one measure was validated in paediatric populations, but not specifically for children with GJH and symptoms. One study assessed fatigue, reporting disabling fatigue to be associated with higher pain intensity. Conclusions There were no agreed sets of outcome measures for children with GJH and symptoms found. The standardisation of assessment tools across paediatric clinical trials is needed. Four constructs of pain, function, quality of life and fatigue are recommended to be included with agreed upon, validated, objective tools

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VARIOUS DIAGNOSTIC MEASURES OF FRAILTY AS PREDICTORS FOR FALLS, WEIGHT CHANGE, QUALITY OF LIFE, AND MORTALITY AMONG OLDER FINNISH MEN

Journal of Frailty & Aging ◽

10.14283/jfa.2017.26 ◽

2017 ◽

pp. 1-6

Author(s):

N.M. Perttila ◽

K.H. Pitkala ◽

H. Kautiainen ◽

R. Tilvis ◽

T. Strandberg

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Weight Change ◽

Frailty Index ◽

Postal Questionnaire ◽

Study Cohort ◽

Diagnostic Measures ◽

Lower Hrqol

Background: Frailty predisposes individuals to a variety of complications. However, there is no consensus on the definition of frailty. Objectives: To examine whether various frailty measures are equivalent in identifying the same individuals as being frail and whether the measures also predict similar outcomes. Design, Setting and Participants: The Helsinki Businessmen Study cohort, which is a long-term observational study of men born in 1919-1934, was used as the population. We investigated these men by their postal questionnaire responses in 2000 and 2005. The mean age of the men (N=480) was 73 years at the start of follow-up. Measurements: We compared two phenotypic frailty measures, the Helsinki Businessmen Study measure (HBS), the modified Women’s Health Initiative Observational Study (WHI-OS), and the Frailty Index (FI) comprising 20 items. All three measurements were applied to Helsinki Businessmen Study cohort data collected via simple postal questionnaire from 480 men. We investigated how effectively these three measures distinguished between the not frail, prefrail, and frail individuals, and predicted mortality, falls, weight change, and health-related quality of life (HRQoL, 15D instrument) during a 5-year follow-up. Results: The HBS and the modified WHI-OS identified 35 persons (7.3%) each as frail but their respective sets comprised different groupings of individuals that partly overlapped. The FI identified 86 persons (17.9%) as frail. One-hundred-and-two (21.3%) men were classified as frail by at least one of the measures. All three measures significantly predicted higher mortality, higher number of fallers, and lower HRQoL for frail participants. None of the measures showed different results for weight change between the frailty groups or frailty stages. Conclusions: All three measures identified somewhat different sets of participants as frail. They all predicted increased mortality, falls and reduced HRQoL for the frail groups.

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A five-year follow-up observational study of the T-14 paediatric throat disorders outcome measure in tonsillectomy and adenotonsillectomy

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2018.0133 ◽

2019 ◽

Vol 101 (1) ◽

pp. 40-43

Author(s):

KM Konieczny ◽

TN Pitts-Tucker ◽

TC Biggs ◽

MB Pringle

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Outcome Measurement ◽

Paediatric Population ◽

Measurement Tool ◽

Postoperative Time ◽

The Mean

Introduction The T-14 questionnaire is a validated outcome measurement tool to assess the value of paediatric tonsillectomy from a parent’s perspective. There is a paucity of data regarding the long-term postoperative effects of tonsillectomy on quality of life in the paediatric population. Our previous study assessed T-14 scores up to year 2 postoperatively, with this study extending follow-up to 5 years. Materials and methods We undertook a prospective uncontrolled observational study examining 54 paediatric patients undergoing tonsillectomy at Portsmouth Hospitals NHS Trust. Parents of children undergoing surgery were invited to complete a T-14 questionnaire preoperatively, as well as at 3 months, 6 months, 1 year, 2 years and now 5 years postoperatively. Results In total, 44 of 54 patients completed questionnaires preoperatively and at all postoperative time points, with 46 being completed at 5 years. There was a highly significant (P < 0.001) difference between the preoperative scores and all other measured T-14 scores postoperatively. The mean score preoperatively was 33.3 compared with 1.0 at 5 years. Conclusions This is the first study to assess long-term quality of life following paediatric tonsillectomy using the T-14 questionnaire. The benefits of tonsillectomy on long-term quality of life further confirms its value within the paediatric population.

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Improvements in Quality of Life in Individuals with Friedreich’s Ataxia after Participation in a 5-Year Program of Physical Activity: An observational Study Pre-Post Test Design, and Two Years Follow-Up

International Journal of Neurorehabilitation ◽

10.4172/2376-0281.1000129 ◽

2014 ◽

Vol 01 (03) ◽

Cited By ~ 1

Author(s):

Jesus Seco Jon Torres Unda

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Observational Study ◽

Friedreich’S Ataxia ◽

Friedreich's Ataxia ◽

Test Design ◽

Post Test

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Long-Term Effectiveness of Guided Self-Help for Parents of Children With ADHD in Routine Care—An Observational Study

Journal of Attention Disorders ◽

10.1177/1087054718810797 ◽

2018 ◽

Vol 25 (2) ◽

pp. 265-274 ◽

Cited By ~ 4

Author(s):

Manfred Döpfner ◽

Hannah Liebermann-Jordanidis ◽

Claudia Kinnen ◽

Nora Hallberg ◽

Laura Mokros ◽

...

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Behavioral Problems ◽

Routine Care ◽

Adhd Symptoms ◽

Children With Adhd ◽

Self Help

Objective:To assess long-term effectiveness of guided self-help for parents of children with ADHD under routine care conditions. Method: 6- to 12-year-old children diagnosed with ADHD were enrolled in an observational study on a 1-year telephone-assisted parent-administered behavioral intervention. N = 136 families who completed the intervention participated in a follow-up assessment. Pre-, post-, and follow-up data were analyzed by repeated measures ANOVA with planned contrasts. Clinical significance was analyzed according to the reliable change index. Results: Child ADHD symptoms (primary outcome), oppositional defiant disorder (ODD) symptoms, overall behavioral problems, and quality of life improved during the intervention. There was a further improvement in ADHD symptoms at follow-up, with a medium effect size. Improvements during treatment in ODD symptoms, overall behavioral problems, and quality of life were maintained at follow-up. Conclusion: The findings suggest that telephone-assisted self-help interventions may result in a long-term reduction of child behavior problems.

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Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review

BMC Pediatrics ◽

10.1186/s12887-021-03009-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Muhammad Maarj ◽

Andrea Coda ◽

Louise Tofts ◽

Cylie Williams ◽

Derek Santos ◽

...

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Outcome Measures ◽

Prospective Observational Study ◽

Joint Hypermobility ◽

Assessment Tools ◽

Post Intervention ◽

Prospective Longitudinal

Abstract Background Generalised joint hypermobility (GJH) is highly prevalent among children and associated with symptoms in a fifth with the condition. This study aimed to synthesise outcome measures in interventional or prospective longitudinal studies of children with GJH and associated lower limb symptoms. Methods Electronic searches of Medline, CINAHL and Embase databases from inception to 16th March 2020 were performed for studies of children with GJH and symptoms between 5 and 18 years reporting repeated outcome measures collected at least 4 weeks apart. Methodological quality of eligible studies were described using the Downs and Black checklist. Results Six studies comprising of five interventional, and one prospective observational study (total of 388 children) met the inclusion criteria. Interventional study durations were between 2 and 3 months, with up to 10 months post-intervention follow-up, while the observational study spanned 3 years. Three main constructs of pain, function and quality of life were reported as primary outcome measures using 20 different instruments. All but one measure was validated in paediatric populations, but not specifically for children with GJH and symptoms. One study assessed fatigue, reporting disabling fatigue to be associated with higher pain intensity. Conclusions There were no agreed sets of outcome measures used for children with GJH and symptoms. The standardisation of assessment tools across paediatric clinical trials is needed. Four constructs of pain, function, quality of life and fatigue are recommended to be included with agreed upon, validated, objective tools.

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