Clinical, radiological and functional outcomes in patients with SARS-CoV-2 pneumonia: a prospective observational study

Abstract Background All over the world, SARS-CoV-2 pneumonia is causing a significant short-term morbidity and mortality, but the medium-term impact on lung function and quality of life of affected patients are still unknown. Methods In this prospective observational study, 39 patients with SARS-CoV-2 pneumonia were recruited from a single COVID-19 hospital in Southern Switzerland. At three months patients underwent radiological and functional follow-up through CT scan, lung function tests, and 6 min walking test. Furthermore, quality of life was assessed through self-reported questionnaires. Results Among 39 patients with SARS-CoV-2 pneumonia, 32 (82% of all participants) presented abnormalities in CT scan and 25 (64.1%) had lung function tests impairment at three months. Moreover, 31 patients (79.5%) reported a perception of poor health due to respiratory symptoms and all 39 patients showed an overall decreased quality of life. Conclusions Medium-term follow up at three months of patients diagnosed with SARS-CoV-2 pneumonia shows the persistence of abnormalities in CT scans, a significant functional impairment assessed by lung function tests and a decreased quality of life in affected patients. Further studies evaluating the long-term impact are warranted to guarantee an appropriate follow-up to patients recovering from SARS-CoV-2 pneumonia.

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Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review

BMC Pediatrics ◽

10.1186/s12887-021-03009-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Muhammad Maarj ◽

Andrea Coda ◽

Louise Tofts ◽

Cylie Williams ◽

Derek Santos ◽

...

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Outcome Measures ◽

Prospective Observational Study ◽

Joint Hypermobility ◽

Assessment Tools ◽

Post Intervention ◽

Prospective Longitudinal

Abstract Background Generalised joint hypermobility (GJH) is highly prevalent among children and associated with symptoms in a fifth with the condition. This study aimed to synthesise outcome measures in interventional or prospective longitudinal studies of children with GJH and associated lower limb symptoms. Methods Electronic searches of Medline, CINAHL and Embase databases from inception to 16th March 2020 were performed for studies of children with GJH and symptoms between 5 and 18 years reporting repeated outcome measures collected at least 4 weeks apart. Methodological quality of eligible studies were described using the Downs and Black checklist. Results Six studies comprising of five interventional, and one prospective observational study (total of 388 children) met the inclusion criteria. Interventional study durations were between 2 and 3 months, with up to 10 months post-intervention follow-up, while the observational study spanned 3 years. Three main constructs of pain, function and quality of life were reported as primary outcome measures using 20 different instruments. All but one measure was validated in paediatric populations, but not specifically for children with GJH and symptoms. One study assessed fatigue, reporting disabling fatigue to be associated with higher pain intensity. Conclusions There were no agreed sets of outcome measures used for children with GJH and symptoms. The standardisation of assessment tools across paediatric clinical trials is needed. Four constructs of pain, function, quality of life and fatigue are recommended to be included with agreed upon, validated, objective tools.

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S10 The Impact of Omalizumab on Lung Function and Quality of Life in Patients with Severe Allergic Asthma in UK Clinical Practice: A multi-centre prospective observational study – APEX II

Thorax ◽

10.1136/thoraxjnl-2015-207770.16 ◽

2015 ◽

Vol 70 (Suppl 3) ◽

pp. A9.2-A10

Author(s):

R Niven ◽

R Kurukulaaratchy ◽

L Heaney

Keyword(s):

Quality Of Life ◽

Clinical Practice ◽

Lung Function ◽

Observational Study ◽

Allergic Asthma ◽

Prospective Observational Study ◽

Severe Allergic Asthma ◽

The Impact

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Quality of Life in Patients with Nasal Obstruction after Septoplasty: A Single Institution Prospective Observational Study

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1722162 ◽

2021 ◽

Author(s):

Justyna Dąbrowska-Bień ◽

Henryk Skarżyński ◽

Sebastian Filip Górski ◽

Piotr Henryk Skarżyński

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Nasal Obstruction ◽

Prospective Observational Study ◽

Common Symptom ◽

Single Institution ◽

High Satisfaction ◽

Symptom Evaluation ◽

The Individual

Abstract Introduction Nasal obstruction is a common symptom in otorhinolaryngological practice. It can impact significantly on the quality of life of the individual. Objective The primary goal of the present study was to evaluate quality of life after septoplasty in adults with nasal obstruction. A secondary goal was to assess the effectiveness of septoplasty. Methods This was a single institution prospective observational study. Patients had experienced septal deviation and symptomatic nasal obstruction with no benefit from medical treatment. There were 51 patients who completed the Nasal Obstruction Symptom Evaluation (NOSE-POL) scale as well as theVisual Analogue Scale (VAS) before undergoing septoplasty, 3 months later, and finally 7 months after surgery. Patients evaluated changes in their nasal obstruction and changes in their quality of life using the Clinical Global Impression Scale (CGI-S). Results There was a significant improvement in nasal obstruction after septoplasty. Before septoplasty, the mean score on NOSE was 60.3 ± 20.4; 3 months after surgery, it was 32.9 ± 16.8; and 7 months after surgery it was 39.6 ± 33.2. The VAS results also proved a significant enhancement in nasal obstruction after septoplasty. Patients reported an improvement in nasal obstruction as well as a positive change in quality of life, confirming the effectiveness of septoplasty. Conclusions In patients with deformed septum, septoplasty contributes to high satisfaction of the patient and a compelling improvement in disease-specific quality of life. The NOSE-POL questionnaire is a useful tool for measuring the outcomes of this procedure.

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Quality of life in patients referring to private osteopathic clinical practice: A prospective observational study

Complementary Therapies in Medicine ◽

10.1016/j.ctim.2014.05.007 ◽

2014 ◽

Vol 22 (4) ◽

pp. 625-631 ◽

Cited By ~ 2

Author(s):

Francesco Cerritelli ◽

Marco Verzella ◽

Gina Barlafante

Keyword(s):

Quality Of Life ◽

Clinical Practice ◽

Observational Study ◽

Prospective Observational Study

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Epidemiology of injuries, treatment (costs) and outcome in burn patients admitted to a hospital with or without dedicated burn centre (Burn-Pro): protocol for a multicentre prospective observational study

BMJ Open ◽

10.1136/bmjopen-2018-023709 ◽

2018 ◽

Vol 8 (11) ◽

pp. e023709 ◽

Cited By ~ 1

Author(s):

Esther MM Van Lieshout ◽

Daan T Van Yperen ◽

Margriet E Van Baar ◽

Suzanne Polinder ◽

Doeke Boersma ◽

...

Keyword(s):

Quality Of Life ◽

Observational Study ◽

Prospective Observational Study ◽

Burn Injury ◽

Treatment Costs ◽

Burn Patients ◽

Severe Burns ◽

Referral Criteria ◽

Age Limit

IntroductionThe Emergency Management of Severe Burns (EMSB) referral criteria have been implemented for optimal triaging of burn patients. Admission to a burn centre is indicated for patients with severe burns or with specific characteristics like older age or comorbidities. Patients not meeting these criteria can also be treated in a hospital without burn centre. Limited information is available about the organisation of care and referral of these patients. The aims of this study are to determine the burn injury characteristics, treatment (costs), quality of life and scar quality of burn patients admitted to a hospital without dedicated burn centre. These data will subsequently be compared with data from patients with<10% total bodysurface area (TBSA) burned who are admitted (or secondarily referred) to a burn centre. If admissions were in agreement with the EMSB, referral criteria will also be determined.Methods and analysisIn this multicentre, prospective, observational study (cohort study), the following two groups of patients will be followed: 1) all patients (no age limit) admitted with burn-related injuries to a hospital without a dedicated burn centre in the Southwest Netherlands or Brabant Trauma Region and 2) all patients (no age limit) with<10% TBSA burned who are primarily admitted (or secondarily referred) to the burn centre of Maasstad Hospital. Data on the burn injury characteristics (primary outcome), EMSB compliance, treatment, treatment costs and outcome will be collected from the patients’ medical files. At 3 weeks and at 3, 6 and 12 months after trauma, patients will be asked to complete the quality of life questionnaire (EuroQoL-5D), and the patient-reported part of the Patient and Observer Scar Assessment Scale (POSAS). At those time visits, the coordinating investigator or research assistant will complete the observer-reported part of the POSAS.Ethics and disseminationThis study has been exempted by the medical research ethics committee Erasmus MC (Rotterdam, The Netherlands). Each participant will provide written consent to participate and remain encoded during the study. The results of the study are planned to be published in an international, peer-reviewed journal.Trial registration numberNTR6565.

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