scholarly journals Characteristics and Prevalence of Early Chronic Obstructive Pulmonary Disease in a Middle-Aged Population: Results from a Nationwide-Representative Sample

2021 ◽  
Vol Volume 16 ◽  
pp. 3083-3091
Author(s):  
Taeyun Kim ◽  
Jehun Kim ◽  
Jun Hyeong Kim
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Representative Sample ◽  
Chronic Obstructive ◽  
Middle Aged ◽  
Obstructive Pulmonary Disease ◽  
Aged Population

scholarly journals Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with chronic obstructive pulmonary disease and asthma: a population-based study

2021 ◽  
pp. 00628-2021
Author(s):  
Elizabeth Benz ◽  
Sara R.A. Wijnant ◽  
Katerina Trajanoska ◽  
Johnmary T. Arinze ◽  
Emmely W. de Roos ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Older People ◽  
Pulmonary Disease ◽  
Mortality Risk ◽  
Study Groups ◽  
Population Based ◽  
Chronic Obstructive ◽  
Middle Aged ◽  
Obstructive Pulmonary Disease ◽  
All Cause Mortality

BackgroundIncreasing evidence suggests that sarcopenia and a higher systemic immune-inflammation index (SII) are linked with morbidity in patients with chronic obstructive pulmonary disease (COPD). However, whether these two conditions contribute to all-cause mortality in middle-aged and older patients with COPD or asthma is unclear. Therefore, we investigated the association between sarcopenia, SII, COPD, or asthma and all-cause mortality in a large-scale population-based setting.MethodsBetween 2009 and 2014, 4482 participants (aged>55 years, 57.3% female) from the population-based Rotterdam Study were included. COPD and asthma patients were clinically and spirometry-based diagnosed. Six study groups were defined according to the presence or absence of COPD or asthma and sarcopenia. Cox regression models were used to assess all-cause mortality in the study groups, adjusted for sex, age, BMI, SII, smoking, oral corticosteroid use and comorbidities. In addition, all participants were categorised into sex-specific quartiles of SII and mortality in these groups was compared.ResultsOver a median follow-up of 6.1 years (IQR 5.0–7.2), 466 (10.4%) persons died. Independent of the presence of sarcopenia, participants with COPD had a higher risk of all-cause mortality (HR: 2.13 [95% CI: 1.46 to 3.12], and HR: 1.70 [95% CI: 1.32 to 2.18]). Compared to lower SII levels, higher SII levels increased mortality risk even in people without sarcopenia, COPD or asthma.ConclusionMiddle-aged and older people with COPD, higher SII levels or sarcopenia had an independently increased mortality risk. Our study suggests prognostic usefulness of routinely evaluating sarcopenia and SII in older people with COPD or asthma.

scholarly journals Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

2002 ◽  
Vol 56 (7) ◽  
pp. 638-643 ◽  
Author(s):  
IC Walda ◽  
C Tabak ◽  
HA Smit ◽  
L Räsänen ◽  
F Fidanza ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
European Countries ◽  
Chronic Obstructive ◽  
Middle Aged ◽  
Obstructive Pulmonary Disease ◽  
Disease Mortality

scholarly journals The Course of Lung Function in Middle-aged Heavy Smokers: Incidence and Time to Early Onset of Chronic Obstructive Pulmonary Disease

2018 ◽  
Vol 198 (11) ◽  
pp. 1449-1451 ◽  
Author(s):  
Hans Petersen ◽  
Akshay Sood ◽  
Francesca Polverino ◽  
Caroline A. Owen ◽  
Victor Pinto-Plata ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Early Onset ◽  
Chronic Obstructive ◽  
Middle Aged ◽  
Obstructive Pulmonary Disease ◽  
Heavy Smokers

scholarly journals Processed Meat Intake and Risk of Chronic Obstructive Pulmonary Disease among Middle-aged Women

2019 ◽  
Vol 14 ◽  
pp. 88-95 ◽  
Author(s):  
Raphaëlle Varraso ◽  
Orianne Dumas ◽  
Krislyn M. Boggs ◽  
Walter C. Willett ◽  
Frank E. Speizer ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Processed Meat ◽  
Middle Aged ◽  
Meat Intake ◽  
Obstructive Pulmonary Disease

Prevalence of respiratory symptoms related to chronic obstructive pulmonary disease and asthma among middle aged and older adults

Respirology ◽  
2002 ◽  
Vol 7 (4) ◽  
pp. 325-331 ◽  
Author(s):  
MICHAEL ABRAMSON ◽  
MELANIE MATHESON ◽  
CATHRYN WHARTON ◽  
MALCOLM SIM
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Older Adults ◽  
Pulmonary Disease ◽  
Respiratory Symptoms ◽  
Chronic Obstructive ◽  
Middle Aged ◽  
Obstructive Pulmonary Disease

scholarly journals Midlife cardiorespiratory fitness and the long-term risk of chronic obstructive pulmonary disease

Thorax ◽  
2019 ◽  
Vol 74 (9) ◽  
pp. 843-848 ◽  
Author(s):  
Gorm Mørk Hansen ◽  
Jacob Louis Marott ◽  
Andreas Holtermann ◽  
Finn Gyntelberg ◽  
Peter Lange ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cardiorespiratory Fitness ◽  
Chronic Obstructive ◽  
Middle Aged ◽  
Reverse Causation ◽  
Obstructive Pulmonary Disease ◽  
Risk Of Death

BackgroundGood midlife cardiorespiratory fitness (CRF) may reduce the risk of chronic obstructive pulmonary disease (COPD). Reverse causation may play a role if follow-up time is short. We examined the association between CRF and both incident COPD and COPD mortality in employed men with up to 46 years follow-up, which allowed us to account for reverse causality.MethodsMiddle-aged men (n=4730) were recruited in 1970–1971. CRF was determined as VO2max by ergometer test. Categories of CRF (low, normal, high) were defined as ± 1 Z-score (± 1 SD) above or below the age-adjusted mean. Endpoints were identified through national registers and defined as incident COPD, and death from COPD. Multi-adjusted Cox models and restricted mean survival times (RMST) were performed.ResultsCompared with low CRF, the estimated risk of incident COPD was 21% lower in participants with normal CRF (HR 0.79, 95% CI 0.63 to 0.99) and 31 % lower with high CRF (HR 0.69, 95% CI 0.52 to 0.91). Compared with low CRF, the risk of death from COPD was 35% lower in participants with normal CRF (HR 0.65, 95% CI 0.46 to 0.91) and 62% lower in participants with high CRF (HR 0.38, 95% CI 0.23 to 0.61). RMST showed a delay to incident COPD and death from COPD in the magnitude of 1.3–1.8 years in normal and high CRF vs low CRF. Test for reverse causation did not alter the results.ConclusionIn a population of healthy, middle-aged men, higher levels of CRF were associated with a lower long-term risk of incident COPD and death from COPD.

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