Medicinal Plants and Natural Products, More Effective and Safer Pharmacological Treatment for the Management of Obesity

2021 ◽  
Vol 22 ◽  
Author(s):  
Harsha Negi ◽  
Meenakshi Gupta ◽  
Ramanpreet Walia ◽  
Moayad Khataibeh ◽  
Maryam Sarwat
Keyword(s):  
Natural Products ◽  
Weight Gain ◽  
Side Effects ◽  
Medicinal Plants ◽  
Mechanism Of Action ◽  
Pancreatic Lipase ◽  
Herbal Products ◽  
Prevalence Of Obesity ◽  
Herbal Plants ◽  
New Compounds

: Obesity is a major lifestyle disorder and it is correlated with several ailments. The prevalence of obesity has elevated over the years and it has become a global health problem. The drugs presently used for managing obesity have several side-effects associated with them such as diarrhoea, leakage of oily stools, etc. On the contrary, herbal plants and natural products are considered safe for use because they have lesser side effects. New compounds isolated from medicinal plants are screened and identified to determine their effectiveness and potential in preventing abnormal weight gain. In this review, the medicinal plants and natural materials were surveyed across the literature to cover those that have potential for managing and controlling weight gain, and their mechanism of action, active component, and experimental methodologies are also included. These herbal products can be developed as formulations for therapeutic use in obesity. The herbal plants mentioned in the review are classified based on their mechanism of action: inhibition of pancreatic lipase and appetite suppression activities. The ability to inhibit pancreatic lipase enzyme has been used to determine the effectiveness of herbal products for the prevention of abnormal weight gain because of its action on dietary fat and suppression of appetite. This review is an attempt to summarize the herbal plants and natural products that can be used to develop formulations effective in controlling weight gain and obesity.

scholarly journals Antiviral Natural Products for Arbovirus Infections

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2796 ◽  
Author(s):  
Vanessa Shi Li Goh ◽  
Chee-Keng Mok ◽  
Justin Jang Hann Chu
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Plant Extracts ◽  
Antiviral Drug ◽  
Good Tolerability ◽  
Antiviral Compounds ◽  
Potential Source ◽  
Herbal Plants ◽  
Antiviral Activities ◽  
Arboviral Diseases

Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

Potential Phytochemical Nanoemulsions in the Treatment of Oral Cancer and Oral Health

2022 ◽  
pp. 330-353
Author(s):  
Dharmeswar Barhoi ◽  
Sweety Nath Barbhuiya ◽  
Sarbani Giri
Keyword(s):  
Natural Products ◽  
Radiation Therapy ◽  
Oral Health ◽  
Side Effects ◽  
Oral Cancer ◽  
Medicinal Plants ◽  
Drug Development ◽  
Health Management ◽  
Free Form ◽  
New Drug Development

Oral cancer is one of the most common types of cancer, and lifestyle factors like extensive consumption of tobacco, betel quid, and alcohol are the major etiological factors of oral cancer. Treatment of oral cancer includes surgery, radiation therapy, and chemotherapy, but this treatment possesses lots of side effects. Therefore, scientists and medical experts are utilizing natural products and medicinal plants for new drug development. Natural products and phytochemicals showed better efficacy with less toxicity. However, most of the phytochemicals showed poor permeability and less bioavailability. To combat this problem, scientists developed nanosized nanoemulsions of phytochemicals to treat various ailments. Nanoemulsions of phytochemicals exhibited better efficacy than their free form due to increased permeability and bioavailability. Numerous phytopharmaceuticals have been formulated for nanoemulsions to date and tested for their anticancer potential against various cancers, including oral cancer and oral health management.

Evaluation of the effects and side effects of pyrrolizidine alkaloids in medicinal plants

2020 ◽  
Author(s):  
Hamed Fathi ◽  
Mohammad Azadbakht ◽  
Niusha Esmaealzadeh
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Pyrrolizidine Alkaloids ◽  
Physiological Activity ◽  
Polar Compounds ◽  
Herbal Products ◽  
Body Tissues ◽  
The World ◽  
Library Resources ◽  
Medicinal Properties

Medicinal plants are rich in secondary metabolites, the most important of which are alkaloids. Alkaloids are organic compounds that have diverse structural and physiological activity. Pyrrolizidine alkaloids are non-polar compounds that have side effects and harmful effects especially hepatotoxicity in addition to its medicinal properties. Therefore, due to the presence of these materials in some medicinal plants and the importance of these materials and consumption of plants, and monitoring and more precision in these cases, this study was carried out. In this paper, the information have been collected from electronic library resources and from reputable sites such as Google Scholar and Scopus, PubMed, ISI (Web of Science), and the related keywords, which was the benchmark for the period between 1991 and 2019, and about 90 articles and non-electronic resources for pyrolyzidine alkaloids, Medicinal plants, their effects, and their experiences and experiences were evaluated. Pyrrolizidine alkoxides in some dark Vegetable plants such as Leguminosae, Asteraceae, Orchidoceae, Boraginaceae family have been reported. Consumption of herbal products has been commonplace from centuries ago and is vital importance in various parts of the world, today. Many alkaloids are mutagenic and carcinogenic to humans. PAS-containing plants are present in most parts of the world and cause poisoning and damage to humans, livestock and wildlife.Pyrrolizidine alkaloids, which are found in some plants, can be harmed to body tissues, important properties and medicinal effects, of course, have also been reported, which requires it to be used for studying, knowing and recognizing the structure, organs and plants.

scholarly journals Exploring the Molecular Mechanisms of Action of Samoan Medicinal Plants via Chemical Genetic Analyses

2021 ◽  
Author(s):  
◽  
Seeseei Molimau-Samasoni
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Aqueous Extract ◽  
Mechanism Of Action ◽  
Condensed Tannin ◽  
Iron Chelation ◽  
Yeast Cells ◽  
Intracellular Iron ◽  
Drug Leads

<p>Natural products are a robust source of drug leads, and medicinal plants have been the source of natural products that are important pharmaceuticals in modern medicine. Samoan medicinal plants have been investigated in the past, but their potential as a source of new drug leads has not been realized. I hypothesized that determining the mechanism of action of Samoan medicinal plant extracts would provide insight into their pharmaceutical potential. The work described herein was carried out on 11 Samoan medicinal plants, from which 22 extracts were prepared. A bioactivity rate of 68% was determined when 15 of the 22 extracts inhibited the growth of yeast (Saccharomyces cerevisiae). The medicinal plant Psychotria insularum was the most potent, thus genome-wide analyses were completed using the haploid deletion mutant library of S. cerevisiae. Yeast strains deficient in iron transport were hypersensitive to the P. insularum aqueous extract. Further investigations showed that exogenous iron supplementation rescued the growth defect induced by P. insularum extracts, suggesting that P. insularum reduced intracellular iron. Fittingly, yeast cells treated with P. insularum extracts contained less intracellular iron than control cells. Paraxodically, the expression levels of iron transporter proteins were upregulated upon extract treatment. When we investigated iron-requiring cellular processes, we found that yeast cells treated with P. insularum extracts exhibited a respiratory deficient phenotype and reduced heme synthesis, indicative of an impaired cellular iron status. These findings suggested that P. insularum reduced bioavailable iron leading to the induction of the low iron response, and indeed the extracts of P. insularum were shown to chelate iron via the iron-chelating CAS assay. To translate results from yeast to mammalian cells, we treated primary murine macrophages with P. insularum extracts and detected an anti-inflammatory response, which we found to correlate with reduced activity of the iron-requiring aconitase enzyme. We further determined using pooled diploid mutant genetic analyses that the extracts of P. insularum did not have a genetic target. To identify the compound mediating the iron chelation mechanism, bioassay-guided isolation was conducted. Fractionation of the crude aqueous extract of P. insularum produced a relatively pure fraction that NMR and the acid-butanol assay identified as a condensed tannin. Together, these results indicate a relationship between iron chelation, a condensed tannin and inflammation. Further, we established an iron chelation mechanism of action by which P. insularum extracts are used to treat inflammation-associated symptoms in traditional Samoan medicine. Lastly, the findings presented here substantiate the reliability of plants with ethnobotanical background as sources for bioactive natural products.</p>

scholarly journals Herbendodontics – Phytotherapy In Endodontics: A Review

2018 ◽  
Vol 11 (2) ◽  
pp. 1073-1082
Author(s):  
Vishnuvardhini. S, Andamuthu Sivakumar ◽  
Vaiyapuri Ravi ◽  
A. S. Prasad ◽  
J.S. Sivakumar
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Antibacterial Effects ◽  
Herbal Preparations ◽  
Chemical Agents ◽  
Herbal Plants ◽  
Health Disorders

Plants have been used for health disorders and to prevent diseases including epidemics since times immemorial. Many plants are used as Phytomedicines in dentistry because they possess varying degree of biological and antibacterial effects. In endodontics, plants and their extract can be used as irrigant and intracanal medicament to prevent the potential side effects caused by conventional chemical agents. Such herbal preparations are derived from the roots, leaves, seeds, stems and flowers of medicinal plants. This paper emphasize on the advantages of different herbal plants and their products when used as phytotherapy in endodontics.

Ethnobotanical and Pharmacological Importance of the Herbal Plants With Anti-Hair Fall and Hair Growth Activities

2020 ◽  
pp. 49-66
Author(s):  
Kiran Mustafa ◽  
Javaria Kanwal ◽  
Sara Musaddiq ◽  
Samia Khakwani
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Beneficial Effect ◽  
Hair Loss ◽  
Hair Growth ◽  
Active Constituent ◽  
Herbal Plants ◽  
Natural Plants

The primary aim of this study is to access the salient herbal plants with the active constituent of potentially anti-hair fall activities. It also presents the various reasons behind hair loss ailments. As part of this study, a focus is placed on active phytochemicals within these medicinal plants or natural products in terms of various hair fall disease treatments. As natural products have a beneficial effect to minimize hair loss and have promoted the potential for new hair growth, it presents the medicinal values of natural plants in reference to safety and effectiveness for health.

Ethnobotanical and Pharmacological Importance of the Herbal Plants With Anti-Hair Fall and Hair Growth Activities

2022 ◽  
pp. 62-75
Author(s):  
Kiran Mustafa ◽  
Javaria Kanwal ◽  
Sara Musaddiq ◽  
Samia Khakwani
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Beneficial Effect ◽  
Hair Loss ◽  
Hair Growth ◽  
Active Constituent ◽  
Herbal Plants ◽  
Natural Plants

The primary aim of this study is to access the salient herbal plants with the active constituent of potentially anti-hair fall activities. It also presents the various reasons behind hair loss ailments. As part of this study, a focus is placed on active phytochemicals within these medicinal plants or natural products in terms of various hair fall disease treatments. As natural products have a beneficial effect to minimize hair loss and have promoted the potential for new hair growth, it presents the medicinal values of natural plants in reference to safety and effectiveness for health.

scholarly journals Pharmacological Developments Obtained from Marine Natural Products and Current Pipeline Perspective

2011 ◽  
Vol 6 (2) ◽  
pp. 1934578X1100600
Author(s):  
Galeano J. Elkin ◽  
Jhon J. Rojas ◽  
Alejandro Martínez
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Drug Development ◽  
Mechanism Of Action ◽  
Marine Organisms ◽  
Bioactive Molecules ◽  
Phase Iii ◽  
New Drug Development ◽  
Therapeutic Alternatives ◽  
Positive Results

Marine organisms represent a new extensive source for bioactive molecules. They have the potential to provide new therapeutic alternatives to treat human diseases. In this paper, we describe and discuss a variety of isolated and semisynthetic molecules obtained from marine sources. These compounds are in phase II, phase III and at the commercialization stage of new drug development. A description of the mechanism of action, dosage used and side effects are also reported. The positive results obtained from these studies have triggered the development of new studies to evaluate the prospects for utilization of marine organisms.

scholarly journals Ethnomedicinal Uses of Some Common Malaysian Medicinal Plants

2021 ◽  
Author(s):  
Idris Adewale Ahmed
Keyword(s):  
Natural Products ◽  
Rural Communities ◽  
Medicinal Plants ◽  
Low Income ◽  
Sustainable Use ◽  
Indigenous Plants ◽  
Herbal Products ◽  
Development Goals ◽  
Indigenous Uses ◽  
Local Plants

Historically, natural products have always been a rich source of novel pharmacological leads, thus, making the ethnobotanical and ethnopharmacological knowledge an important and major asset of the medicinal plant-based drug discovery in providing hints for effective and safe chemotherapeutic compounds. Such knowledge, however, requires a thorough review and documentation of the ethnomedicinal and indigenous uses of local plants of every part of the world. Malaysia is a global hub for natural products which contributes to its GDP. Malaysia is also one of the 12 most diverse Megabiodiversity countries. Its rainforest is ranked 4th on the list of biodiversity hotspots in Asia after India, China, and Indonesia and is also acknowledged as the world’s oldest rainforest. Natural products are relevant to both Malaysian health care and agriculture which are parts of the national key economic areas (NKEA) under the Government’s Economic Transformation Plan as well as parts of the United Nations’ 17 Sustainable Development Goals (SDGs). Though the quality, efficacy, and safety of herbal products require global and international standardization, herbal products should be made accessible to low-income and rural communities across the globe. The proper documentation of the ethnopharmacological important plants in addition to their preservation and cultivation would enhance the sustainable use of the various indigenous plants. This work is unique in the sense that it is meant to review some of the most important high-value herbal products in Malaysia. Though it covers only a few representatives of Malaysian medicinal plants.

scholarly journals Development of Poly Herbal Cream Formulations Containing Wild Growing Omani Medicinal Plants

2021 ◽  
pp. 57-65
Author(s):  
Mullaicharam Bhupathyraaj ◽  
Lakshmi Sreenath ◽  
Hanan Obaid Al-Habsi ◽  
Nirmala Halligudi
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Sebaceous Gland ◽  
Contact Allergy ◽  
Research Work ◽  
Aloe Vera ◽  
Herbal Medication ◽  
Herbal Plants ◽  
Limiting Condition ◽  
Bacterial Effect

Acne is derived from the Greek word “acme” which means “prime of life”. It is mostly considered to be benign and self-limiting condition but if it is ignored than it can progress to lifetime presence and scaring of the skin. Almost 85% of adolescence are affected by acne and from here males are at higher ration that female due to testosterone level that causes increase size in sebaceous gland which in turn causes more production of sebum (oil production). Women are affected more during adulthood due to imbalance of premenstrual hormones and over use of oil based cosmetics. There are many different factors that contribute to acne formation and it has many different forms. Herbal medication are considered safer than allopathic medicines because allopathic medicines are associated with various side effects such as like contact allergy, local irritation, scaling, photosensitivity, itching, redness, skin peeling, necrosis of the skin etc. In this study there are 3 herbal plants were used to prepare cream formulation that were used to investigate the anti-acne property. The aim of this research work was to develop formulations and to perform its evaluation as an herbal anti-acne cream. The objective of this study was to focus on the ant-acne or anti-bacterial effect of the formulated polyherbal cream containing three plants, Thyme, Aloe Vera and Basil. The results showed that the formulation 10 showed potential anti-acne property had that twice more concentration of aloe Vera than basil and thyme.

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