Association Between Blood Pressure and Branched-Chain/Aromatic Amino Acid Excretion Rate in 24-Hour Urine Samples from Elderly Hypertension Patients

Amino acid excretion was studied in young, healthy men during summer, fall and winter months in a southwestern U. S. location. Both untimed and timed urine samples were employed. The amino acids determined were alanine, arginine, cysteine, glutamic acid, glutamine, glycine, histidine, lysine, methyl histidine, serine, threonine and valine. Supplemental determinations included urine volume, creatinine, uric acid, urea, sodium and potassium. Using untimed urine samples and expressing values as ratios with creatinine, significant seasonal variation was found for alanine, arginine, cysteine, glutamic acid, glycine, lysine and serine. Submitted on April 11, 1959

Download Full-text

Exercise-induced changes in branched chain amino acid/aromatic amino acid ratio in the rat brain and plasma.

The Japanese Journal of Pharmacology ◽

10.1254/jjp.45.243 ◽

1987 ◽

Vol 45 (2) ◽

pp. 243-248 ◽

Cited By ~ 9

Author(s):

Koji OKAMURA ◽

Futoshi MATSUBARA ◽

Yasuyuki YOSHIOKA ◽

Noriaki KIKUCHI ◽

Yuko KIKUCHI ◽

...

Keyword(s):

Amino Acid ◽

Rat Brain ◽

Aromatic Amino Acid ◽

Branched Chain Amino Acid ◽

Acid Ratio ◽

Branched Chain ◽

Exercise Induced ◽

Induced Changes

Download Full-text

Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance

British Journal Of Nutrition ◽

10.1017/s0007114521002920 ◽

2021 ◽

pp. 1-30

Author(s):

L.E. González-Salazar ◽

O. Granados-Portillo ◽

I. Medina-Vera ◽

E. Pichardo-Ontiveros ◽

A. Vigil-Martínez ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Amino Acid ◽

Biochemical Parameters ◽

Dietary Intervention ◽

Energy Restriction ◽

Fat Free Mass ◽

Oral Glucose ◽

Branched Chain ◽

Age And Sex

Abstract Background & aims: Branched-chain amino acids (BCAAs) are considered markers of insulin resistance (IR) in subjects with obesity. In this study, we evaluated whether the presence of a single nucleotide polymorphism (SNP) of the branched-chain aminotransferase 2 (BCAT2) gene can modify the effect of a dietary intervention (DI) on the plasma concentration of BCAAs in subjects with obesity and IR. Methods: A prospective cohort study of adult subjects with obesity, body mass index (BMI) ≥ 30 kg/m2, IR (HOMA-IR ≥ 2.5) no diagnosed chronic disease, underwent a DI with an energy restriction of 750 kcal/d and nutritional education for one month. Anthropometric measurements, body composition, blood pressure, resting energy expenditure (REE), oral glucose tolerance test (OGTT) results, serum biochemical parameters and the plasma amino acid profile were evaluated before and after the DI. SNPs were assessed by the TaqMan SNP genotyping assay. Results: A total of 82 subjects were included, 15 subjects with a BCAT2 SNP had a greater reduction in leucine, isoleucine, valine, and the sum of BCAAs. Those subjects also had a greater reduction in skeletal muscle mass, fat free mass, total body water, blood pressure, muscle strength and biochemical parameters after one month of the DI and adjusting for age and sex. Conclusions: This study demonstrated that the presence of the BCAT2 SNP promotes a greater reduction in plasma BCAA concentration after adjusting for age and sex, in subjects with obesity and IR after a one-month energy-restricted DI.

Download Full-text