Children’s Lipid Accumulation Product Combining Visceral Adiposity Index is a Novel Indicator for Predicting Unhealthy Metabolic Phenotype Among Chinese Children and Adolescents

Objective To compare the effects of resistance and aerobic training (RT and AT) on spexin (SPX), appetite, lipid accumulation product (LAP), visceral adiposity index (VAI), and body composition in type 2 diabetes mellitus (T2DM) patients. Materials and Methods: Thirty-six T2DM men were randomized to receive RT ( n = 12), AT ( n = 12), or to act as a non-exercise control (CON, n = 12) 3 days a week for 12 weeks. Results: SPX was increased after both RT and AT (66.2% and 46.5%, respectively). VAI, LAP, and homeostasis model assessment-insulin resistance (HOMA-IR) were reduced in both groups, while quantitative insulin sensitivity check index (Quicki) and McAuley’s indexes were increased following both interventions. However, the increases of both hunger and PFC in the RT group were greater than those of the AT. Moreover, the improvement of upper-body strength (41% vs. 10.3%) and lower-body strength (42.2% vs. 20.5%) in the RT group was greater than those of the AT. Conclusion: Our investigation shows that regardless of the modes of the regimen, a 12-week exercise intervention with RT and AT can effectively induce a significant improvement in SPX levels, appetite, LAP, VAI, and body composition in adults with T2DM.

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Adiposity Indexes as Phenotype-Specific Markers of Preclinical Metabolic Alterations and Cardiovascular Risk in Polycystic Ovary Syndrome: A Cross-Sectional Study

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0042-119524 ◽

2017 ◽

Vol 125 (05) ◽

pp. 307-315 ◽

Cited By ~ 5

Author(s):

Fernanda Mario ◽

Scheila Graff ◽

Poli Spritzer

Keyword(s):

Cardiovascular Risk ◽

Polycystic Ovary Syndrome ◽

Lipid Accumulation ◽

Polycystic Ovary ◽

Visceral Adiposity ◽

Visceral Adiposity Index ◽

Lipid Accumulation Product ◽

Ovary Syndrome ◽

Metabolic Alterations ◽

Adiposity Index

AbstractPolycystic ovary syndrome (PCOS) is a common condition in women of reproductive age. 2 PCOS phenotypes (classic and ovulatory) are currently recognized as the most prevalent, with important differences in terms of cardiometabolic features. We studied the performance of different adiposity indexes to predict preclinical metabolic alterations and cardiovascular risk in 234 women with PCOS (173 with classic and 61 with ovulatory PCOS) and 129 controls. Performance of waist circumference, waist-to-height ratio, conicity index, lipid accumulation product, and visceral adiposity index was assessed based on HOMA-IR ≥ 3.8 as reference standard for screening preclinical metabolic alterations and cardiovascular risk factors in each group. Lipid accumulation product had the best accuracy for classic PCOS, and visceral adiposity index had the best accuracy for ovulatory PCOS. By applying the cutoff point of lipid accumulation product<34, we identified a subgroup of patients without cardiometabolic alterations (P<0.05) in the group with classic PCOS, a population at higher risk for hypertension, dyslipidemia, and impaired glucose tolerance. In ovulatory PCOS, visceral adiposity index ≥ 1.32 was capable of detecting women with significantly higher blood pressure and less favorable glycemic and lipid variables as compared to ovulatory PCOS with lower visceral adiposity index (P<0.05). These results suggest LAP ≥ 34 as the best marker for classic PCOS, and VAI ≥ 1.32 for ovulatory PCOS women. Both indexes can be easily calculated with measures obtained in routine clinical practice and may be useful to detect cardiometabolic risk and secure early interventions.

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Visceral adiposity index performed better than traditional adiposity indicators in predicting unhealthy metabolic phenotype among Chinese children and adolescents

Scientific Reports ◽

10.1038/s41598-021-03311-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yangyang Dong ◽

Ling Bai ◽

Rongrong Cai ◽

Jinyu Zhou ◽

Wenqing Ding

Keyword(s):

Body Mass Index ◽

Children And Adolescents ◽

Receiver Operating Characteristic ◽

Body Mass ◽

Operating Characteristic ◽

Normal Weight ◽

Visceral Adiposity ◽

Metabolic Phenotype ◽

Visceral Adiposity Index ◽

Adiposity Index

AbstractThe relationship between visceral adiposity index (VAI) and unhealthy metabolic phenotype remained unclear in children and adolescents. This study aimed to investigate their association and compared the ability of VAI and traditional adiposity indicators (body mass index, waist circumference and waist-to-height ratio) to predict metabolically unhealthy phenotype among normal-weight, overweight and obese children and adolescents. In this cross-sectional study, 1722 children and adolescents aged 12–18 years were selected by cluster random sampling, underwent a questionnaire survey, physical examination and biochemical tests. Participants were divided into four phenotypes according to the combination of the weight status determined by body mass index (BMI) and metabolic syndrome components. Receiver operating characteristic (ROC) analysis and multivariate logistic regression were used to compare the predictive capacity between VAI and traditional adiposity indicators and their relationship with metabolically unhealthy phenotype. We found that VAI had better performance in predicting metabolically unhealthy phenotype than traditional adiposity indicators, the area under the receiver-operating characteristic curve (AUC) were 0.808 and 0.763 for boys and girls with normal-weight, 0.829 and 0.816 for boys and girls with overweight and obese (all P < 0.001). VAI was most strongly related to metabolically unhealthy phenotype whether or not to adjust the age, the adjusted OR and 95%CI was 6.15 (4.13–9.14) in boys with normal weight, and 5.90 (3.06–11.36), 4.95 (2.35–10.41) in boys and girls with overweight and obese, respectively (all P < 0.001). Our findings suggested VAI could be used as a comprehensive predictor to identify unhealthy metabolic phenotype in children and adolescents.

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Prediction of metabolically unhealthy phenotype by the visceral adiposity index, lipid accumulation product and triglyceride-glucose index in Chinese women with polycystic ovary syndrome

10.26226/morressier.5912d9efd462b802923866b2 ◽

2017 ◽

Author(s):

Hang Wun Raymond Li

Keyword(s):

Polycystic Ovary Syndrome ◽

Lipid Accumulation ◽

Chinese Women ◽

Polycystic Ovary ◽

Visceral Adiposity ◽

Visceral Adiposity Index ◽

Lipid Accumulation Product ◽

Ovary Syndrome ◽

Adiposity Index ◽

Triglyceride Glucose Index

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A novel indicator, relative children’s lipid accumulation product (RCLAP) for metabolic syndrome

10.21203/rs.3.rs-91096/v1 ◽

2020 ◽

Author(s):

Li Zhang ◽

Zizhe Zhang ◽

Bangxuan Wang ◽

Yongting Yuan ◽

Lili Sun ◽

...

Keyword(s):

Children And Adolescents ◽

Lipid Accumulation ◽

Vigorous Physical Activity ◽

Roc Curves ◽

Chinese Children ◽

Cluster Sampling ◽

Activity Time ◽

Lipid Accumulation Product ◽

Increased Risk ◽

Chinese Children And Adolescents

Abstract BackgroundThe children’s lipid accumulation product (CLAP) was associated with MS in Chinese children and adolescents. The study was to develop a more effective indicator, relative children’s lipid accumulation product （RCLAP）associated with MS reflect the density of lipid accumulation among Chinese children and adolescents. MethodsA stratified cluster sampling method was used to recruit 683 students aged 8-15 years in this study. The presence of MS was defined according to the NCEP-ATP III criteria. The t-test, chi-square test, logistic regression models were used to analyze the associations of SBMI, SWHtR, SlnCLAP, SRCLAP-H, SRCLAP-SH, RCLAP-W with MS. Receiver Operating Characteristic (ROC) curves was used to evaluate the predictive efficiency of above indexes for predicting MS. ResultsThe overall prevalence of MS was 4.8% (boys 6.6%, girls 2.8%). In girls, after adjusting for sedentary activity time, WHtR, BMI, CLAP, RCLAP-H, RCLAP-SH and RCLAP-W significantly increased risk of MS (OR(95%CI):15.79 (3.15-79.21), 3.73 (0.87-15.95), Null, 96.13 (11.11-831.97), 96.13 (11.11-831.97), 18.28 (4.24-78.87), respectively). In boys, after adjusting for ages and moderate-to-vigorous physical activity time, WHtR, BMI, CLAP, RCLAP-H, RCLAP-SH and SRCLAP-W significantly increased risk of MS (OR(95%CI): 37.43(11.67-120.10), 68.33(18.51-252.20), 105.86(21.99-509.68), 171.75(33.60-878.00), 133.18(27.65-641.39), 50.13(15.48-162.37, respectively). The AUCs of RCLAP-H and RCLAP-SH for predicting MS were 0.950, 0.948 in girls, and 0.952, 0.952 in boys, which were higher than these of BMI, WHtR, CLAP and RCLAP-W.ConclusionThe relative children，s lipid accumulation products（RCLAP-H and RCLAP-SH ) were more effective indicators for predicting MS than BMI, WHtR and CLAP in Chinese children and adolescents.

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