Analysis of the Therapeutic Effects of Staged Posterior–Anterior Combined Surgery for Cervicothoracic Segmental Tuberculosis with Kyphosis in Pediatric Patients

Objectives: Rituximab is frequently used off-label for the treatment of frequent-relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS), but the relapse rate remained high and the dosing regimen varied widely. The objective of this study was to characterize rituximab pharmacokinetics (PK) in pediatric patients with FRNS/SDNS, and to investigate the differences in rituximab PK between patients with FRNS/SDNS and other disease populations.Methods: Fourteen pediatric patients received rituximab for FRNS/SDNS treatment were enrolled in a prospective, open-label, single-center PK study. A population PK model of rituximab was developed and validated, and PK parameters were derived for quantitative evaluation.Results: A two-compartment PK model best described the data. Body surface area was the most significant covariate for both central clearance (CL) and apparent central volume of distribution (V1). Patients with FRNS/SDNS exhibited a clinically relevant increase in rituximab CL compared to patient population with non-Hodgkin’s lymphoma (NHL).Conclusion: This pilot study indicated that higher doses or more frequent regimens of rituximab may be required for optimal therapeutic effects in patients with FRNS/SDNS. Further clinical studies with more patients are warranted to confirm this result.

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Evaluasi Rasionalitas dan Efektifitas Penggunaan Antibiotik pada Pasien Pneumonia Pediatrik di Instalasi Rawat Inap Rumah Sakit Pusat Jawa Tengah

Pharmacon Jurnal Farmasi Indonesia ◽

10.23917/pharmacon.v14i2.6524 ◽

2019 ◽

Vol 14 (2) ◽

pp. 62-71

Author(s):

Mahardika Putri Bestari ◽

Hidayah Karuniawati

Keyword(s):

Pediatric Patients ◽

Respiratory Infections ◽

Data Retrieval ◽

Therapeutic Effects ◽

Central Java ◽

Record Data ◽

Center Hospital ◽

Combination Antibiotics ◽

Result Analysis ◽

Parasitic Pathogens

Pneumonia is a respiratory infections disease are caused by bacterial, viral, fungal and parasitic pathogens that cause deaths in children, especially toddlers and increasing number incidents per year. Treatment of pneumonia treated with antibiotics rational and effective because can improve clinical therapeutic effects, minimize drug toxicity, reduce the incidence of resistance that leads to treatment failure, and more economically. The purpose of this study are to determine the rationale and effectiveness of antibiotic therapy. This study was an observational study with retrospective data retrieval using medical record data of pediatric patients diagnosed pneumonia in center hospital, Central Java. The results of 90 cases studied were 60% of patients treated with single antibiotics and 40% of patients treated with combination antibiotics. The most antibiotics given in single therapy were ampicillin (22,2%), amoxicillin (16,7%), and ceftriaxone (15,6%). While antibiotics in combination therapy was ampicillin with gentamicin 31.2%. rationality result analysis was: right indication 100%; proper patients 100%; appropriate medicines 72,2%; appropriate dose 9,23% and rational antibiotics 6,67%. Giving antibiotics ampicillin with gentamycin effective in eradicating bacteria this could be seen with temperature and leukocyte rate down, antibiotics did not improve on symptoms of patients.

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Posterior/anterior combined surgery for thoracolumbar burst fractures—posterior instrumentation with pedicle screws and laminar hooks, anterior decompression and strut grafting

Spinal Cord ◽

10.1038/sc.2010.159 ◽

2010 ◽

Vol 49 (4) ◽

pp. 573-579 ◽

Cited By ~ 14

Author(s):

M Machino ◽

Y Yukawa ◽

K Ito ◽

H Nakashima ◽

F Kato

Keyword(s):

Posterior Instrumentation ◽

Pedicle Screws ◽

Anterior Decompression ◽

Combined Surgery ◽

Thoracolumbar Burst Fractures ◽

Burst Fractures ◽

Laminar Hooks ◽

Posterior Anterior

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Audiology Service Models in a Family Physician Practice Setting

Perspectives on Audiology ◽

10.1044/poa6.1.24 ◽

2010 ◽

Vol 6 (1) ◽

pp. 24-32 ◽

Cited By ~ 2

Author(s):

Sridhar Krishnamurti

Keyword(s):

Pediatric Patients ◽

Practice Patterns ◽

Healthcare Delivery ◽

Direct Consequence ◽

Direct Access ◽

Practice Setting ◽

Pediatric Populations ◽

Family Practice Physicians ◽

Primary Focus ◽

Balance Problems

This article illustrates the potential of placing audiology services in a family physician’s practice setting to increase referrals of geriatric and pediatric patients to audiologists. The primary focus of family practice physicians is the diagnosis/intervention of critical systemic disorders (e.g., cardiovascular disease, diabetes, cancer). Hence concurrent hearing/balance disorders are likely to be overshadowed in such patients. If audiologists get referrals from these physicians and have direct access to diagnose and manage concurrent hearing/balance problems in these patients, successful audiology practice patterns will emerge, and there will be increased visibility and profitability of audiological services. As a direct consequence, audiological services will move into the mainstream of healthcare delivery, and the profession of audiology will move further towards its goals of early detection and intervention for hearing and balance problems in geriatric and pediatric populations.

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