Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method

2010 ◽

Vol 3 (3) ◽

pp. 1136-1146

Author(s):

V K Verma ◽

Ram A

Keyword(s):

Electron Microscopy ◽

Particle Size ◽

Solid Lipid Nanoparticles ◽

In Vitro Release ◽

Entrapment Efficiency ◽

Lipid Nanoparticles ◽

Diffusion Method ◽

Solid Lipid ◽

Vitro Release

Solid lipid nanoparticles (SLNs) of piroxicam where produced by solvent emulsification diffusion method in a solvent saturated system. The SLNs where composed of tripamitin lipid, polyvinyl alcohol (PVAL) stabilizer, and solvent ethyl acetate. All the formulation were subjected to particle size analysis, zeta potential, drug entrapment efficiency, percent drug loading determination and in-vitro release studies. The SLNs formed were nano-size range with maximum entrapment efficiency. Formulation with 435nm in particle size and 85% drug entrapment was subjected to scanning electron microscopy (SEM) and transmission electron microscopy (TEM) for surface morphology, differential scanning calorimetry (DSC) for thermal analysis and short term stability studies. SEM and TEM confirm that the SLNs are nanometric size and circular in shape. The drug release behavior from SLNs suspension exhibited biphasic pattern with an initial burst and prolong release over 24 h.

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Characterization of Solid Lipid Nanoparticles Containing Caffeic Acid and Determination of its Effects on MCF-7 Cells

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574892810666150115124413 ◽

2015 ◽

Vol 10 (2) ◽

pp. 224-232 ◽

Cited By ~ 5

Author(s):

Gokhan Dikmen ◽

Gamze Guney ◽

Lutfi Genc

Keyword(s):

Caffeic Acid ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Solid Lipid ◽

Mcf 7

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Preparation and characterization of black seed oil loaded solid lipid nanoparticles for topical formulations: A preliminary study

10.1063/5.0052706 ◽

2021 ◽

Author(s):

Acharee Suksuwan ◽

Zamzam Arour ◽

Najwa Santiworakun ◽

Winai Dahlan

Keyword(s):

Solid Lipid Nanoparticles ◽

Seed Oil ◽

Lipid Nanoparticles ◽

Topical Formulations ◽

Solid Lipid ◽

Black Seed ◽

Preliminary Study ◽

Black Seed Oil

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Effects of doxorubicin on the structural and morphological characterization of solid lipid nanoparticles (SLN) using small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS)

Physica B Condensed Matter ◽

10.1016/j.physb.2017.12.036 ◽

2018 ◽

Vol 551 ◽

pp. 191-196 ◽

Cited By ~ 2

Author(s):

Fabiano Yokaichiya ◽

Christian Schmidt ◽

Joachim Storsberg ◽

Mont Kumpugdee Vollrath ◽

Daniele Ribeiro de Araujo ◽

...

Keyword(s):

Neutron Scattering ◽

Small Angle ◽

Solid Lipid Nanoparticles ◽

Small Angle Neutron Scattering ◽

Lipid Nanoparticles ◽

Morphological Characterization ◽

X Ray ◽

Solid Lipid ◽

X Ray Scattering

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Nephrotoxicity of Albendazole and Albendazole-Loaded Solid Lipid Nanoparticles in Mice with Experimental Hydatidosis

Advanced Pharmaceutical Bulletin ◽

10.34172/apb.2022.011 ◽

2021 ◽

Author(s):

Kobra Kohansal ◽

Abdollah Rafiei ◽

Heibatullah Kalantari ◽

Ali Jelowdar ◽

Anayatollah Salimi ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Physicochemical Characterization ◽

Public Health Problem ◽

New Product ◽

Lipid Nanoparticles ◽

Control Group ◽

Histopathological Study ◽

Normal Range ◽

Solid Lipid

Purposes: Cystic echinococcosis (CE) is a serious contemporary public health problem. Different CE treatment methods are of considerable importance, with albendazole (ABZ) being one of the most preferred drugs for CE treatment and prophylaxis. In this study, we evaluated the nephrotoxicity caused by ABZ and ABZ-loaded solid lipid nanoparticles (SLNs) in mice with experimental hydatid cyst. Methods: ABZ-loaded SLNs were produced by micro-emulsification and a high shear homogenization technique. Thereafter, we evaluated the physicochemical characterization of the product. Live protoscolices were injected into mice to induce experimental hydatidosis. Mice were then treated with ABZ and ABZ-loaded SLNs. The nephrotoxicity effects were evaluated by biochemical and histopathological surveys. Results: Significantly different blood urea nitrogen (BUN) levels were observed between the two infected groups (ABZ treatment and ABZ-loaded SLN treatment) and the control group. The kidney malondialdehyde (MDA) and glutathione (GSH) levels of the infected groups were not significantly different from those of the control group. The histopathological study revealed nephropathic and pathologic changes in the ABZ and ABZ-loaded SLN groups. Conclusion: ABZ formulated for ABZ-loaded SLNs had a more prominent chemoprophylactic efﬁcacy on CE and fewer side effects than ABZ alone. Neither ABZ nor ABZ-loaded SLNs caused significant biochemical and histopathological defects on the kidney, and all functional biochemical markers stayed within the normal range. Therefore, ABZ-loaded SLNs could be a potential new product for CE treatment.

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