The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation

Nanoparticles in the drugs are useful for the treatment of cancer due to their unique properties and can act as drug carriers in different ways. Unlike the traditional chemotherapy, the entrance of nanotechnology enabled wide applications in treatment of cancer. Although nanoparticles provides safe and effective drug delivery systems but the factor of toxicity still limits the utilisation of several nanoparticles. The properties of nanodrug carriers are controllable by various factors. The use of nanoparticles in cancer therapy by drug delivery and their advantages as been reviewed.

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Understanding the behavior of nanoparticulate drug delivery systems in vivo: particle disposition patterns, toxicologic implications and effective drug development

Toxicology Letters ◽

10.1016/j.toxlet.2013.06.152 ◽

2013 ◽

Vol 221 ◽

pp. S42

Author(s):

Richard Kirsh ◽

Steven Hood ◽

Joel Parry ◽

Jan Losos ◽

Christine Merrill ◽

...

Keyword(s):

Drug Delivery ◽

Drug Development ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Effective Drug

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Novel approaches in development of cell penetrating peptides

Journal of Applied Pharmaceutical Research ◽

10.18231/joapr.2021.9.1.08.24 ◽

2021 ◽

Vol 9 (1) ◽

pp. 1-7

Author(s):

Vatsal R. Shah ◽

Yamini D. Shah ◽

Mansi N. Athalye

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Drug Delivery Systems ◽

Cell Penetrating Peptides ◽

Delivery Systems ◽

Endosomal Escape ◽

Effective Drug ◽

Cell Penetrating ◽

Potential Benefits ◽

Novel Approaches

Therapeutic cargos which are impermeable to the cell can be delivered by cell penetrating peptides (CPPs). CPP-cargo complexes accumulate by endocytosis inside the cells but they fail to reach the cytosolic space properly as they are often trapped in the endocytic organelles. Here the CPP mediated endosomal escape and some strategies used to increase endosomal escape of CPP-cargo conjugates are discussed with evidence. Potential benefits can be obtained by peptides such as reduction in side effects, biocompatibility, easier synthesis and can be obtained at lower administered doses. The particular peptide known as cell penetrating peptides are able to translocate themselves across membrane with the carrier drugs with different mechanisms. This is of prime importance in drug delivery systems as they have capability to cross physiological membranes. This review describes various mechanisms for effective drug delivery and associated challenges

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Tuning the properties of pH responsive nanoparticles to control cellular interactions in vitro and ex vivo

Polymer Chemistry ◽

10.1039/c6py01332e ◽

2016 ◽

Vol 7 (38) ◽

pp. 6015-6024 ◽

Cited By ~ 13

Author(s):

S. K. Mann ◽

A. Dufour ◽

J. J. Glass ◽

R. De Rose ◽

S. J. Kent ◽

...

Keyword(s):

Drug Delivery ◽

Human Blood ◽

Drug Delivery Systems ◽

Cultured Cells ◽

Ex Vivo ◽

Delivery Systems ◽

Effective Drug ◽

Cellular Interactions ◽

Ph Responsive

Engineering the properties of nanoparticles to limit non-specific cellular interactions is critical for developing effective drug delivery systems. Differences between interactions with cultured cells and human blood highlights the need for appropriate assays.

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Multiple mRNAs controlled and heat-driven drug release from gold nanocages in targeted chemo-photothermal therapy for tumor

Chemical Science ◽

10.1039/d1sc02017j ◽

2021 ◽

Author(s):

hao zhang ◽

ze gao ◽

Xiaoxiao Li ◽

Lu Li ◽

Sujuan Ye ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Cancer Treatment ◽

Photothermal Therapy ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Effective Drug ◽

Comprehensive Treatment ◽

Gold Nanocages

The multifunctional drug delivery systems enabling the effective drug delivery and comprehensive treatment is critical to successful cancer treatment. It still remains challenging for precise drug delivery to overcome nonspecific...

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