scholarly journals Novel preparation method for sustained-release PLGA microspheres using water-in-oil-in-hydrophilic-oil-in-water emulsion

2013 ◽  
pp. 2433 ◽  
Author(s):  
Weien Yuan ◽  
Xiaoyun Hong ◽  
Yinghui Chen ◽  
Liuqing Ma ◽  
Zhenguo Liu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Preparation Method ◽  
Plga Microspheres ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion

Sustained release of low molecular weight heparin from PLGA microspheres prepared by a solid-in-oil-in-water emulsion method

2011 ◽  
Vol 28 (8) ◽  
pp. 763-770 ◽  
Author(s):  
Jintian He ◽  
Zhitao Zhou ◽  
Yangyang Fan ◽  
Xianglian Zhou ◽  
Huijuan Du
Keyword(s):  
Molecular Weight ◽  
Sustained Release ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Plga Microspheres ◽  
Water Emulsion ◽  
Emulsion Method ◽  
Oil In Water ◽  
Oil In Water Emulsion

Influence of the preparation method on the structure formed by ovalbumin/gum arabic to observe the stability of oil-in-water emulsion

2017 ◽  
Vol 63 ◽  
pp. 602-610 ◽  
Author(s):  
Fuge Niu ◽  
Yating Zhang ◽  
Cuihua Chang ◽  
Weichun Pan ◽  
Wanhai Sun ◽  
...  
Keyword(s):  
Preparation Method ◽  
Gum Arabic ◽  
Water Emulsion ◽  
Oil In Water ◽  
The Stability ◽  
Oil In Water Emulsion

scholarly journals Qualification of Non-Halogenated Organic Solvents Applied to Microsphere Manufacturing Process

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 425 ◽  
Author(s):  
Hyunjin Shim ◽  
Hongkee Sah
Keyword(s):  
Solvent Extraction ◽  
Ethyl Acetate ◽  
Manufacturing Process ◽  
Ethyl Formate ◽  
Plga Microspheres ◽  
Water Emulsion ◽  
Residual Solvent ◽  
Emulsion Droplets ◽  
Oil In Water ◽  
Oil In Water Emulsion

As a non-halogenated dispersed solvent, ethyl acetate has been most commonly used for the manufacturing of poly-d,l-lactide-co-glycolide (PLGA) microspheres. However, ethyl acetate-based microencapsulation processes face several limitations. This study was aimed at proposing ethyl formate as an alternative. Evaluated in this study was the solvent qualification of ethyl formate and ethyl acetate for microencapsulation of a hydrophobic drug into PLGA microspheres. An oil-in-water emulsion solvent extraction technique was developed to load progesterone into PLGA microspheres. Briefly, right after emulsion droplets were temporarily stabilized, they were subject to primary solvent extraction. Appearing semisolid, embryonic microspheres were completely hardened through subsequent secondary solvent extraction. Changes in process parameters of the preparative technique made it possible to manipulate the properties of emulsion droplets, progesterone behavior, and microsphere quality. Despite the two solvents showing comparable Hansen solubility parameter distances toward PLGA, ethyl formate surpassed ethyl acetate in relation to volatility and water miscibility. These features served as advantages in the microsphere manufacturing process, helping produce PLGA microspheres with better quality in terms of drug crystallization, drug encapsulation efficiency, microsphere size homogeneity, and residual solvent content. The present ethyl formate-based preparative technique could be an attractive method of choice for the production of drug-loaded PLGA microspheres.

Impact of Oil-in-Water Emulsion Composition and Preparation Method on Emulsion Physical Properties and Friction Behaviors

2014 ◽  
Vol 56 (1) ◽  
pp. 143-160 ◽  
Author(s):  
Helen S. Joyner ◽  
Chris W. Pernell ◽  
Christopher R. Daubert
Keyword(s):  
Physical Properties ◽  
Preparation Method ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion

scholarly journals  Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method

2012 ◽  
pp. 4559 ◽  
Author(s):  
Weien Yuan ◽  
Guang Liu ◽  
Xiaoyun Hong ◽  
Mier Jiang
Keyword(s):  
Sustained Release ◽  
Water Emulsion ◽  
Emulsion Method ◽  
Oil In Water ◽  
Oil In Water Emulsion

Oil-in-water emulsion development for the encapsulation and sustained release of xanthone

2019 ◽  
Vol 41 (3) ◽  
pp. 355-361
Author(s):  
Nelida Yanina Martinez ◽  
Mario Sergio Moreno
Keyword(s):  
Sustained Release ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion

Pharmacokinetics of an Oil-in-Water Emulsion Containing Isocarbacyclin Methyl Ester, TTC-909. (3). Tissue Distribution in Rats after Single Intravenous Administration.

1995 ◽  
Vol 10 (3) ◽  
pp. 332-343
Author(s):  
Yoshiro KOHNO ◽  
Toshiya MINAGAWA ◽  
Toshio SUWA ◽  
Shiro KONDO ◽  
Yoshio ESUMI ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Tissue Distribution ◽  
Intravenous Administration ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion ◽  
Single Intravenous Administration
Sign in / Sign up

Export Citation Format

Share Document