Sustained release of low molecular weight heparin from PLGA microspheres prepared by a solid-in-oil-in-water emulsion method

2011 ◽  
Vol 28 (8) ◽  
pp. 763-770 ◽  
Author(s):  
Jintian He ◽  
Zhitao Zhou ◽  
Yangyang Fan ◽  
Xianglian Zhou ◽  
Huijuan Du
Keyword(s):  
Molecular Weight ◽  
Sustained Release ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Plga Microspheres ◽  
Water Emulsion ◽  
Emulsion Method ◽  
Oil In Water ◽  
Oil In Water Emulsion

Effect of medium molecular weight xanthan gum in rheology and stability of oil-in-water emulsion stabilized with legume proteins

2005 ◽  
Vol 85 (12) ◽  
pp. 1967-1973 ◽  
Author(s):  
Evdoxia M Papalamprou ◽  
Eleousa A Makri ◽  
Vassilios D Kiosseoglou ◽  
Georgios I Doxastakis
Keyword(s):  
Molecular Weight ◽  
Xanthan Gum ◽  
Water Emulsion ◽  
Oil In Water ◽  
Legume Proteins ◽  
Oil In Water Emulsion

Preparation of porous alumina microspheres via an oil-in-water emulsion method accompanied by a sol–gel process

2016 ◽  
Vol 40 (1) ◽  
pp. 589-595 ◽  
Author(s):  
Hui Yang ◽  
Yuan Xie ◽  
Guisong Hao ◽  
Weiwei Cai ◽  
Xingzhong Guo
Keyword(s):  
Porous Alumina ◽  
Sol Gel ◽  
Three Dimensional ◽  
Water Emulsion ◽  
Emulsion Method ◽  
Oil In Water ◽  
Sol Gel Process ◽  
Template Free ◽  
Oil In Water Emulsion ◽  
Interconnected Structure

Porous alumina microspheres prepared via a facile template-free approach followed by heat-treatment, exhibiting a three-dimensional interconnected structure.

Carbon foams prepared by an oil-in-water emulsion method

Carbon ◽  
2007 ◽  
Vol 45 (13) ◽  
pp. 2710-2712 ◽  
Author(s):  
Mingxian Liu ◽  
Lihua Gan ◽  
Fengqi Zhao ◽  
Huixiang Xu ◽  
Xuezhong Fan ◽  
...  
Keyword(s):  
Water Emulsion ◽  
Emulsion Method ◽  
Oil In Water ◽  
Carbon Foams ◽  
Oil In Water Emulsion

scholarly journals Qualification of Non-Halogenated Organic Solvents Applied to Microsphere Manufacturing Process

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 425 ◽  
Author(s):  
Hyunjin Shim ◽  
Hongkee Sah
Keyword(s):  
Solvent Extraction ◽  
Ethyl Acetate ◽  
Manufacturing Process ◽  
Ethyl Formate ◽  
Plga Microspheres ◽  
Water Emulsion ◽  
Residual Solvent ◽  
Emulsion Droplets ◽  
Oil In Water ◽  
Oil In Water Emulsion

As a non-halogenated dispersed solvent, ethyl acetate has been most commonly used for the manufacturing of poly-d,l-lactide-co-glycolide (PLGA) microspheres. However, ethyl acetate-based microencapsulation processes face several limitations. This study was aimed at proposing ethyl formate as an alternative. Evaluated in this study was the solvent qualification of ethyl formate and ethyl acetate for microencapsulation of a hydrophobic drug into PLGA microspheres. An oil-in-water emulsion solvent extraction technique was developed to load progesterone into PLGA microspheres. Briefly, right after emulsion droplets were temporarily stabilized, they were subject to primary solvent extraction. Appearing semisolid, embryonic microspheres were completely hardened through subsequent secondary solvent extraction. Changes in process parameters of the preparative technique made it possible to manipulate the properties of emulsion droplets, progesterone behavior, and microsphere quality. Despite the two solvents showing comparable Hansen solubility parameter distances toward PLGA, ethyl formate surpassed ethyl acetate in relation to volatility and water miscibility. These features served as advantages in the microsphere manufacturing process, helping produce PLGA microspheres with better quality in terms of drug crystallization, drug encapsulation efficiency, microsphere size homogeneity, and residual solvent content. The present ethyl formate-based preparative technique could be an attractive method of choice for the production of drug-loaded PLGA microspheres.

scholarly journals Antifibrotic therapy by sustained release of low molecular weight heparin from poly(lactic-co-glycolic acid) microparticles on bleomycin-induced pulmonary fibrosis in mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Takashi Saito ◽  
Takuya Kotani ◽  
Koichi Suzuki
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Glycolic Acid ◽  
Pathological Condition ◽  
Lung Fibroblasts ◽  
Low Molecular Weight ◽  
Sustained Drug Release ◽  
Cell Culture Study ◽  
Water Emulsion ◽  
Plga Microparticles

Abstract Heparin and low molecular weight heparin (LMWH) have recently been considered useful treatment tools for inflammation. Heparin has antifibrotic activity, mediated by cellular secretion of hepatocyte growth factor (HGF). HGF has antifibrotic properties demonstrated in experimental models of lung, kidney, heart, skin, and liver fibrosis. The ability of LMWH for HGF secretion is similar to that of normal heparin. Poly (lactic-co-glycolic acid) (PLGA) is widely used for sustained drug release, because of its biocompatibility and low toxicity. LMWH-loaded PLGA microparticles are prepared by a conventional water-in-oil-in-water emulsion method. Interstitial pneumonia is a life-threatening pathological condition that causes respiratory failure when it progresses. In the present study, we investigated the therapeutic effect of LMWH-loaded PLGA microparticles in a mouse model of bleomycin-induced lung fibrosis. The ratios of fibrotic area to total area were significantly lower in mice administered LMWH-loaded microparticles than in mice administered bleomycin alone. The microparticle administration did not further enhance the gene expression for inflammatory cytokines. In a cell culture study, HGF secretion by mouse and human lung fibroblasts was significantly increased by LMWH addition. We conclude that LMWH showed anti-inflammatory activity, through the effects of LMWH-loaded PLGA microparticles on cells at sites of inflammation.

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