scholarly journals Transparent, biocompatible nanostructured surfaces for cancer cell capture and culture

2014 ◽  
pp. 2569 ◽  
Author(s):  
Bin Xiong ◽  
Boran Cheng ◽  
Zhaobo He ◽  
Libo Zhao ◽  
Yuanyuan Chen ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Capture ◽  
Nanostructured Surfaces

scholarly journals Folic acid modified electrospun poly(vinyl alcohol)/polyethyleneimine nanofibers for cancer cell capture applications

2016 ◽  
Vol 34 (6) ◽  
pp. 755-765 ◽  
Author(s):  
Zhang-yu Fan ◽  
Yi-li Zhao ◽  
Xiao-yue Zhu ◽  
Yu Luo ◽  
Ming-wu Shen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cell ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Cell Capture

PDMS micropillar-based microchip for efficient cancer cell capture

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 52161-52166 ◽  
Author(s):  
Jingrong Xiao ◽  
Weiqi He ◽  
Zhengtao Zhang ◽  
Weiying Zhang ◽  
Yiping Cao ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Microfluidic Device ◽  
Cell Capture

We introduce a micropillar-based microfluidic device for efficient and rapid cancer cell capture.

A Magnetic Dynamic Microbiointerface with Biofeedback Mechanism for Cancer Cell Capture and Release

2019 ◽  
Vol 11 (44) ◽  
pp. 41019-41029 ◽  
Author(s):  
Xiaohua Tian ◽  
Xiangyu Sha ◽  
Yonghai Feng ◽  
Yuqing Duan ◽  
Mingdong Dong ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Capture ◽  
Magnetic Dynamic ◽  
Capture And Release

The effect of protein expression on cancer cell capture using the Human Transferrin Receptor (CD71) as an affinity ligand

2019 ◽  
Vol 1076 ◽  
pp. 154-161 ◽  
Author(s):  
Veronica J. Lyons ◽  
Amanda Helms ◽  
Dimitri Pappas
Keyword(s):  
Protein Expression ◽  
Cancer Cell ◽  
Transferrin Receptor ◽  
Cell Capture ◽  
Human Transferrin ◽  
Affinity Ligand ◽  
Human Transferrin Receptor

Bladder Cancer Cell Capture: Elucidating the Effect of Sample Storage Conditions on Capturing Bladder Cancer Cells via Surface Immobilized EpCAM Antibody

2019 ◽  
Vol 2 (9) ◽  
pp. 3730-3736 ◽  
Author(s):  
Kola Ostrikov ◽  
Thomas Michl ◽  
Melanie MacGregor ◽  
Krasimir Vasilev
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Storage Conditions ◽  
Bladder Cancer Cell ◽  
Cell Capture ◽  
Sample Storage ◽  
Bladder Cancer Cells

scholarly journals Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Michael J. Mitchell ◽  
Carlos A. Castellanos ◽  
Michael R. King
Keyword(s):  
Cell Adhesion ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Cell ◽  
Halloysite Nanotubes ◽  
Breast Adenocarcinoma ◽  
Hematogenous Metastasis ◽  
Mcf7 Cells ◽  
Nanostructured Surfaces ◽  
Cancer Cell Death

Hematogenous metastasis, the process of cancer cell migration from a primary to distal location via the bloodstream, typically leads to a poor patient prognosis. Selectin proteins hold promise in delivering drug-containing nanocarriers to circulating tumor cells (CTCs) in the bloodstream, due to their rapid, force-dependent binding kinetics. However, it is challenging to deliver such nanocarriers while avoiding toxic effects on healthy blood cells, as many possess ligands that adhesively interact with selectins. Herein, we describe a nanostructured surface to capture flowing cancer cells, while preventing human neutrophil adhesion. Microtube surfaces with immobilized halloysite nanotubes (HNTs) and E-selectin functionalized liposomal doxorubicin (ES-PEG L-DXR) significantly increased the number of breast adenocarcinoma MCF7 cells captured from flow, yet also significantly reduced the number of captured neutrophils. Neutrophils firmly adhered and projected pseudopods on surfaces coated only with liposomes, while neutrophils adherent to HNT-liposome surfaces maintained a round morphology. Perfusion of both MCF7 cells and neutrophils resulted in primarily cancer cell adhesion to the HNT-liposome surface, and induced significant cancer cell death. This work demonstrates that nanostructured surfaces consisting of HNTs and ES-PEG L-DXR can increase CTC recruitment for chemotherapeutic delivery, while also preventing healthy cell adhesion and uptake of therapeutic intended for CTCs.

Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip for cancer cell capture and culture

2017 ◽  
Vol 5 (4) ◽  
pp. 752-761 ◽  
Author(s):  
Gangwei Xu ◽  
Yulong Tan ◽  
Tiegang Xu ◽  
Di Yin ◽  
Mengyuan Wang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Microfluidic Chip ◽  
Cell Capture

Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip are able to effectively capture cancer cells.

Hyaluronic Acid-Functionalized Electrospun Polyvinyl Alcohol/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications

2015 ◽  
Vol 2 (15) ◽  
pp. 1500256 ◽  
Author(s):  
Yili Zhao ◽  
Zhangyu Fan ◽  
Mingwu Shen ◽  
Xiangyang Shi
Keyword(s):  
Hyaluronic Acid ◽  
Polyvinyl Alcohol ◽  
Cancer Cell ◽  
Cell Capture

Trap Effect of Three-Dimensional Fibers Network for High Efficient Cancer-Cell Capture

2015 ◽  
Vol 4 (6) ◽  
pp. 838-843 ◽  
Author(s):  
Lan Ma ◽  
Gao Yang ◽  
Nü Wang ◽  
Pengchao Zhang ◽  
Fengyun Guo ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Three Dimensional ◽  
Cell Capture ◽  
High Efficient

Dendrimer-functionalized electrospun cellulose acetate nanofibers for targeted cancer cell capture applications

2014 ◽  
Vol 2 (42) ◽  
pp. 7384-7393 ◽  
Author(s):  
Yili Zhao ◽  
Xiaoyue Zhu ◽  
Hui Liu ◽  
Yu Luo ◽  
Shige Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Cellulose Acetate ◽  
Cancer Cell ◽  
Cell Capture

Multifunctional folic acid-functionalized dendrimers can be modified on the surface of electrospun cellulose acetate nanofibers for the specific capture of FAR-overexpressing cancer cells.

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