scholarly journals Biotite-Calx Based Traditional Indian Medicine Sahastraputi-Abhrak-Bhasma Prophylactically Mitigates Allergic Airway Inflammation in a Mouse Model of Asthma by Amending Cytokine Responses

2021 ◽  
Vol Volume 14 ◽  
pp. 4743-4760
Author(s):  
Acharya Balkrishna ◽  
Siva Kumar Solleti ◽  
Hoshiyar Singh ◽  
Rani Singh ◽  
Niti Sharma ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Cytokine Responses ◽  
Traditional Indian Medicine ◽  
Indian Medicine

OVA-Induced Allergic Airway Inflammation Mouse Model

2018 ◽  
pp. 297-301 ◽  
Author(s):  
Mateus Casaro ◽  
Vanessa R. Souza ◽  
Fernando A. Oliveira ◽  
Caroline M. Ferreira
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation

scholarly journals Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhidan Li ◽  
Wei Zhang ◽  
Fang Luo ◽  
Jian Li ◽  
Wenbin Yang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protective Effect ◽  
Airway Inflammation ◽  
Lung Tissue ◽  
Immunoglobulin E ◽  
Allergic Airway Inflammation ◽  
Treg Cells ◽  
Protective Effects ◽  
Novel Therapy ◽  
Allergen Sensitization

Schistosoma japonicum infection showed protective effects against allergic airway inflammation (AAI). However, controversial findings exist especially regarding the timing of the helminth infection and the underlying mechanisms. Most previous studies focused on understanding the preventive effect of S. japonicum infection on asthma (infection before allergen sensitization), whereas the protective effects of S. japonicum infection (allergen sensitization before infection) on asthma were rarely investigated. In this study, we investigated the protective effects of S. japonicum infection on AAI using a mouse model of OVA-induced asthma. To explore how the timing of S. japonicum infection influences its protective effect, the mice were percutaneously infected with cercaria of S. japonicum at either 1 day (infection at lung-stage during AAI) or 14 days before ovalbumin (OVA) challenge (infection at post–lung-stage during AAI). We found that lung-stage S. japonicum infection significantly ameliorated OVA-induced AAI, whereas post–lung-stage infection did not. Mechanistically, lung-stage S. japonicum infection significantly upregulated the frequency of regulatory T cells (Treg cells), especially OVA-specific Treg cells, in lung tissue, which negatively correlated with the level of OVA-specific immunoglobulin E (IgE). Depletion of Treg cells in vivo partially counteracted the protective effect of lung-stage S. japonicum infection on asthma. Furthermore, transcriptomic analysis of lung tissue showed that lung-stage S. japonicum infection during AAI shaped the microenvironment to favor Treg induction. In conclusion, our data showed that lung-stage S. japonicum infection could relieve OVA-induced asthma in a mouse model. The protective effect was mediated by the upregulated OVA-specific Treg cells, which suppressed IgE production. Our results may facilitate the discovery of a novel therapy for AAI.

scholarly journals Ascaris lumbricoides Cystatin Prevents Development of Allergic Airway Inflammation in a Mouse Model

2019 ◽  
Vol 10 ◽  
Author(s):  
Sandra Coronado ◽  
Josefina Zakzuk ◽  
Ronald Regino ◽  
Velky Ahumada ◽  
Ines Benedetti ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Ascaris Lumbricoides ◽  
Allergic Airway Inflammation

Inhaled Carbenoxolone Prevents Allergic Airway Inflammation and Airway Hyperreactivity in a Mouse Model of Asthma

2008 ◽  
Vol 149 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Arjun Ram ◽  
Shashi Kant Singh ◽  
Vijay Pal Singh ◽  
Sarvesh Kumar ◽  
Balaram Ghosh
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Airway Hyperreactivity

GARP inhibits allergic airway inflammation in a humanized mouse model

Allergy ◽  
2016 ◽  
Vol 71 (9) ◽  
pp. 1274-1283 ◽  
Author(s):  
H. Meyer-Martin ◽  
S. A. Hahn ◽  
H. Beckert ◽  
C. Belz ◽  
A. Heinz ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Humanized Mouse ◽  
Humanized Mouse Model

scholarly journals Suppression of allergic airway inflammation in a mouse model by Der p2 recombined BCG

Immunology ◽  
2009 ◽  
Vol 128 (1pt2) ◽  
pp. e343-e352 ◽  
Author(s):  
Hai-Feng Ou-Yang ◽  
Xing-Bin Hu ◽  
Xin-Yu Ti ◽  
Jie-Ran Shi ◽  
Shu-Jun Li ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Der P2
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