Corneal Hysteresis in Thais and Variation of Corneal Hysteresis in Glaucoma

AbstractTo evaluate the role of corneal hysteresis (CH) as a risk factor for progressive ONH surface depression and RNFL thinning measured by confocal scanning laser ophthalmoscopy (CSLO) and spectral-domain optical coherence tomography (SD-OCT), respectively in glaucoma patients. Prospective study. A total of 146 eyes of 90 patients with glaucoma were recruited consecutively. The CH measurements were acquired at baseline and 4-months interval using the Ocular Response Analyzer (Reichert Instruments, Depew, NY). Eyes were imaged by CSLO (Heidelberg Retinal Tomograph [HRT]; Heidelberg Engineering, GmbH, Dossenheim, Germany) and SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec AG, Dublin, CA) at approximately 4-month intervals for measurement of ONH surface topography and RNFL thickness, respectively. Significant ONH surface depression and RNFL thinning were defined with reference to Topographic Change Analysis (TCA) with HRT and Guided Progression Analysis (GPA) with Cirrus HD-OCT, respectively. Multivariate cox proportional hazards models were used to investigate whether CH is a risk factor for ONH surface depression and RNFL progression after adjusting potential confounding factors. All patients with glaucoma were followed for an average of 6.76 years (range, 4.56–7.61 years). Sixty-five glaucomatous eyes (44.5%) of 49 patients showed ONH surface depression, 55 eyes (37.7%) of 43 patients had progressive RNFL thinning and 20 eyes (13.7%) of 17 patients had visual field progression. In the cox proportional hazards model, after adjusting baseline diastolic IOP, CCT, age, baseline disc area and baseline MD, baseline CH was significantly associated with ONH surface depression and visual field progression (HR = 0.71, P = 0.014 and HR = 0.54, P = 0.018, respectively), but not with RNFL thinning (HR = 1.03, P = 0.836). For each 1-mmHg decrease in baseline CH, the hazards for ONH surface depression increase by 29%, and the hazards for visual field progression increase by 46%. The CH measurements were significantly associated with risk of glaucoma progression. Eyes with a lower CH were significantly associated with an increased risk of ONH surface depression and visual field progression in glaucoma patients.

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A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma

American Journal of Ophthalmology ◽

10.1016/j.ajo.2017.12.018 ◽

2018 ◽

Vol 187 ◽

pp. 148-152 ◽

Cited By ~ 19

Author(s):

Carolina N. Susanna ◽

Alberto Diniz-Filho ◽

Fábio B. Daga ◽

Bianca N. Susanna ◽

Feilin Zhu ◽

...

Keyword(s):

Risk Factor ◽

Longitudinal Study ◽

Corneal Hysteresis ◽

Prospective Longitudinal Study ◽

Prospective Longitudinal

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Relative Importance of Factors Affecting Corneal Hysteresis Measurement

Optometry and Vision Science ◽

10.1097/opx.0b013e3182504214 ◽

2012 ◽

Vol 89 (5) ◽

pp. E803-E811 ◽

Cited By ~ 15

Author(s):

Michael Sullivan-Mee ◽

Suchitra Katiyar ◽

Denise Pensyl ◽

Kathy D. Halverson ◽

Clifford Qualls

Keyword(s):

Corneal Hysteresis ◽

Relative Importance ◽

Factors Affecting

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Assessment of corneal hysteresis measured by the ocular response analyzer as a screening tool in patients with glaucoma

Clinical Ophthalmology ◽

10.2147/opth.s168032 ◽

2018 ◽

Vol Volume 12 ◽

pp. 1809-1813 ◽

Cited By ~ 4

Author(s):

Justin A Schweitzer ◽

Molly Ervin ◽

John P Berdahl

Keyword(s):

Screening Tool ◽

Corneal Hysteresis ◽

Ocular Response Analyzer

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Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314370 ◽

2019 ◽

Vol 104 (4) ◽

pp. 563-568 ◽

Cited By ~ 2

Author(s):

Masato Matsuura ◽

Hiroshi Murata ◽

Yuri Fujino ◽

Mieko Yanagisawa ◽

Yoshitaka Nakao ◽

...

Keyword(s):

Intraocular Pressure ◽

Central Corneal Thickness ◽

Linear Regression Analysis ◽

Corneal Thickness ◽

Biomechanical Properties ◽

Applanation Tonometry ◽

Corneal Hysteresis ◽

Corneal Resistance Factor ◽

Corvis St ◽

The Relationship

AimsCorvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA).MethodsA total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) underwent IOP measurements with GAT, CST and ORA. The relationships between IOP measurements (ORA-IOPg, ORA-IOPcc, CST-bIOP and GAT IOP) and biomechanical properties (CCT, CH and corneal resistance factor (CRF)) were analysed using the linear regression analysis.ResultsIOPg, IOPcc and GAT IOP were significantly associated with CCT (p<0.001), whereas bIOP was not significantly associated with CCT (p=0.19). IOPg, bIOP and GAT IOP were significantly associated with CH (IOPg: p<0.001; bIOP: p<0.001; GAT IOP: p=0.0054), whereas IOPcc was not significantly associated with CH (p=0.18). All of IOP records were associated with CRF (p<0.001).ConclusionThe bIOP measurement from CST is independent from CCT, but dependent on CH and CRF.

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Relationship between optic disc hemorrhage and corneal hysteresis

Canadian Journal of Ophthalmology ◽

10.1016/j.jcjo.2019.10.007 ◽

2020 ◽

Vol 55 (3) ◽

pp. 239-244

Author(s):

Nathan M. Radcliffe ◽

Nathaniel Tracer ◽

Carlos Gustavo V. De Moraes ◽

Celso Tello ◽

Jeffrey M. Liebmann ◽

...

Keyword(s):

Optic Disc ◽

Corneal Hysteresis ◽

Disc Hemorrhage

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Conventional Versus Accelerated Collagen Cross-Linking for Keratoconus: A Comparison of Visual, Refractive, Topographic and Biomechanical Outcomes

The Open Ophthalmology Journal ◽

10.2174/1874364101711010262 ◽

2017 ◽

Vol 11 (1) ◽

pp. 262-272 ◽

Cited By ~ 11

Author(s):

Jyh Haur Woo ◽

Jayant Venkatramani Iyer ◽

Li Lim ◽

M Htoon Hla ◽

Jodhbir S Mehta ◽

...

Keyword(s):

Visual Acuity ◽

Endothelial Cell ◽

Cell Loss ◽

Corneal Topography ◽

Resistance Factor ◽

Corneal Hysteresis ◽

Cross Linking ◽

Corneal Resistance Factor ◽

Accelerated Crosslinking

Objective: The aim was to compare the visual, refractive, topographic and biomechanical outcomes in patients with progressive keratoconus treated with either conventional or accelerated crosslinking at one year follow up. Methods: It is a prospective, non-randomised interventional study of 76 patients who underwent conventional (CXL; 3mW/cm2 for 30 minutes) or accelerated cross linking (KXL; 30mW/cm2 for 4 minutes) for progressive keratoconus. Baseline and postoperative visual acuity, manifest refraction, corneal topography, pachymetry, endothelial cell density and biomechanical parameters of corneal hysteresis and corneal resistance factor were evaluated and compared. Results: The 2 groups were comparable in terms of uncorrected and best corrected visual acuity and spherical equivalent. Both groups showed no significant increase in K1, K2 and Kmean from baseline at 12 months. There was also no difference between the CXL and KXL group for postoperative corneal topography as well as central and minimal pachymetry up to 12 months. There was a significant increase in both corneal hysteresis (0.62mm Hg, P=0.04) and corneal resistance factor (0.91mm Hg, P=0.003) in the KXL group at 12 months but not in the CXL group. There was no significant endothelial cell loss throughout follow up in both the groups. Conclusion: We have established comparability of the 2 protocols in stabilizing the progression of keratoconus. Our findings also suggested an added biomechanical advantage of accelerated crosslinking at 1 year follow up.

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Role of corneal biomechanical properties in predicting of speed of myopic progression in children wearing orthokeratology lenses or single-vision spectacles

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2018-000204 ◽

2018 ◽

Vol 3 (1) ◽

pp. e000204 ◽

Cited By ~ 3

Author(s):

Kin Wan ◽

Sin Wan Cheung ◽

James S Wolffsohn ◽

Janis B Orr ◽

Pauline Cho

Keyword(s):

Axial Length ◽

Corneal Thickness ◽

Significant Negative Correlation ◽

Biomechanical Properties ◽

Corneal Hysteresis ◽

Axial Elongation ◽

Single Vision ◽

Length Data ◽

Corneal Biomechanical Properties

ObjectiveTo determine the characteristics of children who were likely to progress rapidly and gain the greatest benefit from orthokeratology (ortho-k) treatment.Methods and analysisThe files of 113 children who participated in two myopia control studies and wore either ortho-k lenses (n=62) or single-vision spectacles (SVS) (n=51) were reviewed. Baseline cycloplegic subjective refraction, central corneal thickness, axial length, keratometry, intraocular pressure, corneal biomechanical properties and 24-month axial length data were retrieved and analysed.ResultsMultivariate analysis showed that there was significant negative correlation between axial elongation and baseline age and corneal hysteresis (p<0.05) in the SVS group. In the ortho-k group, only baseline age was significantly and negatively associated with axial elongation (p<0.01).ConclusionCorneal biomechanical properties and baseline age can predict the rate of axial elongation in myopic children. It may be beneficial for younger myopic children with low corneal hysteresis to commence ortho-k treatment as early as possible.

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