Increased prevalence of coronary artery disease risk markers in patients with chronic hepatitis C – a cross-sectional study

CONTEXT AND OBJECTIVE: Atherosclerotic disease is the leading cause of death in Brazil. It is a complex disease and its prevention involves identification and control of risk factors. Moderately increased plasma homocysteine concentration (hyperhomocysteinemia) has been considered to be a risk factor for several vascular diseases. Mutations in the methylenetetrahydrofolate reductase (MTHFR) enzyme, which is involved in homocysteine metabolism, have been investigated as potential vascular disease risk factors. G1793A polymorphism was described in 2002 and there are few studies analyzing its involvement in diseases. The objective of this study was to investigate the prevalence of G1793A polymorphism in subjects with early coronary artery disease (CAD). DESIGN AND SETTING: Cross-sectional study with control group conducted at a private cardiology clinic and a molecular biology laboratory (Universidade do Vale do Itajaí). METHODS: We studied 74 early-onset CAD+ patients and 40 CAD- individuals with normal angiography results. DNA was extracted from blood samples. Molecular data were obtained via PCR/RFLP and agarose gel electrophoresis. RESULTS: The occurrence of G1793A heterozygotes was similar in the control (5%) and test (6.25%) groups, thus showing that in the population studied there was no correlation between the marker and occurrences of early CAD. There was also no association between the polymorphism and the risk factors for atherosclerosis. CONCLUSIONS: The frequency of the 1793A allele in the test group (3.4%) was similar to what was found in the control individuals (2.5%). There was no correlation between G1793A polymorphism and occurrences of early CAD in this population.

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Assessment of high-sensitivity C-reactive protein and lipid levels in healthy adults and patients with coronary artery disease, with and without periodontitis - a cross-sectional study

Journal of Periodontal Research ◽

10.1111/jre.12172 ◽

2014 ◽

Vol 49 (6) ◽

pp. 836-844 ◽

Cited By ~ 7

Author(s):

K. R. V. Kumar ◽

V. Ranganath ◽

R. Naik ◽

S. Banu ◽

A. S. Nichani

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

High Sensitivity ◽

Cross Sectional Study ◽

Sectional Study ◽

Lipid Levels ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Artery Disease

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Association between plasma lipids, and apolipoproteins and coronary artery disease: a cross-sectional study in a low-risk Korean population

International Journal of Cardiology ◽

10.1016/j.ijcard.2004.03.057 ◽

2005 ◽

Vol 101 (3) ◽

pp. 435-440 ◽

Cited By ~ 18

Author(s):

Hyung-Kwan Kim ◽

Sung-A Chang ◽

Eue-Keun Choi ◽

Yong-Jin Kim ◽

Hyo-Soo Kim ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Plasma Lipids ◽

Cross Sectional Study ◽

Low Risk ◽

Korean Population ◽

Sectional Study ◽

Cross Sectional ◽

Artery Disease

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How Fast Foods Impact Coronary Artery Disease Incidence: A Cross-Sectional Study

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2021.3.5.1033 ◽

2021 ◽

Vol 3 (5) ◽

pp. 52-55

Author(s):

Khudayenoor ◽

Ayesha Shaheen ◽

Aimen Fatima ◽

Zohaib Saleem ◽

Hafeez Arshad ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Fast Food ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Fast Foods ◽

High Prevalence ◽

Artery Disease ◽

The Impact

Coronary artery disease (CAD) is a very ordinary health problem around the globe. CAD is affected by numerous factors like diabetes, obesity, smoking, gender, and diet. However, the association of CAD with diet is understudied in our region that’s why our study was aimed to evaluate the effect of diet on CAD incidence. This cross-sectional study was completed among local population of Rawalpindi, Pakistan in almost 6 months from November 2020 to April 2021. People were taken in our study via set criteria. Data was collected by self-structured proforma. Data analysis was performed by applying IBM SPSS version 25. Descriptive statistics were applied for quantitative variables. Statistical tests like Chi-square test and Spearman correlation analysis were applied to know the association, direction, and strength of study variables. Our current study displays overall high prevalence CAD (17.48%) among study population. Mean value of age for study participants was 45.42 with SD of ±8.01years. Prevalence of CAD was more common among females, faster food eaters and fresh fruit and raw vegetables non-eaters. Gender, fast food, and fresh fruits and vegetables were associated with CHD significantly with p-values 0.030, 0.0007, and 0.0006 respectively. Strength and direction for fast food and CAD association was very strong and positive while for association between fresh fruits and raw vegetables and CAD was very strong and negative with correlation coefficient +0.812 and -0.831 respectively. In a nutshell, current study indicates high prevalence of CAD especially among females, fast food eaters and fresh fruits and raw vegetables non-eaters. Higher consumption of fast foods leads to higher incidence of CAD and vice versa while higher consumption of fresh fruits and raw vegetables bring down the incidence of CAD incidence and vice versa. So, we need to create awareness among people about the impact of food on CAD and gender specific interventions for each gender to lower down the CAD incidence.

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