scholarly journals THERAPEUTIC TARGETING OF HYPOXIA-INDUCIBLE FACTOR SIGNALING PATHWAYS- A PROMISING APPROACH IN CANCER TREATMENT

2020 ◽  
Vol 8 (9) ◽  
pp. 1332-1337
Author(s):  
Anjum Mohammad Shaik ◽  
◽  
Valli Harisomayajula ◽  
Saranya M.L ◽  
Phani Greeshma Veeramachaneni ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Immune Cells ◽  
Cell Cycle Regulation ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factors ◽  
Low Oxygen ◽  
Therapeutic Targeting ◽  
Expression Of Genes ◽  
Transcription Regulators ◽  
Cycle Regulation

Oxygen and nutrients are delivered to the cells with the help of the vascular networking system, which makes availability of oxygen as primary regulator for many processes. Low oxygen availability condition activates the Hypoxia Inducible Factors (HIF), which are transcription regulators helping in the expression of genes related to cell cycle regulation and angiogenesis. HIF is hence regarded as the master regulator of angiogenesis. The oxygen deprival is due to the increased consumption of oxygen in the tumor microenvironment and in turn leads to hypoxia. A thorough understanding of how hypoxia influences angiogenesis mediated by several pathways has become essential for identifying novel strategies targeting HIF thereby blocking angiogenesis. In this review we would discuss about the HIF signaling pathways and altered functions of immune cells due to hypoxia by considering that reducing or targeting hypoxia may in turn prevent the suppression of anti-tumor immune response.

scholarly journals Erratum to: Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts

2016 ◽  
Vol 424 (1-2) ◽  
pp. 211-211
Author(s):  
Marta Moskot ◽  
Joanna Jakóbkiewicz-Banecka ◽  
Elwira Smolińska ◽  
Ewa Piotrowska ◽  
Grzegorz Węgrzyn ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Replication ◽  
Cell Cycle Regulation ◽  
Human Fibroblasts ◽  
Expression Of Genes ◽  
Cycle Regulation

scholarly journals Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?

Critical Care ◽  
2018 ◽  
Vol 22 (1) ◽  
Author(s):  
Juliana Monte Real ◽  
Ludmila Rodrigues Pinto Ferreira ◽  
Gustavo Henrique Esteves ◽  
Fernanda Christtanini Koyama ◽  
Marcos Vinícius Salles Dias ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Septic Shock ◽  
Signaling Pathways ◽  
Cell Cycle Regulation ◽  
Cycle Regulation

scholarly journals Changes in the expression of genes involved in cell cycle regulation and the relative telomere length in the process of canceration induced by omethoate

Tumor Biology ◽  
2017 ◽  
Vol 39 (7) ◽  
pp. 101042831771978 ◽  
Author(s):  
Xiaoran Duan ◽  
Yongli Yang ◽  
Sihua Wang ◽  
Xiaolei Feng ◽  
Tuanwei Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Telomere Length ◽  
Cell Cycle Regulation ◽  
Relative Telomere Length ◽  
Expression Of Genes ◽  
Cycle Regulation

scholarly journals Hypoxia-Inducible Factor in Thyroid Carcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-17 ◽  
Author(s):  
Natalie Burrows ◽  
Muhammad Babur ◽  
Julia Resch ◽  
Kaye J. Williams ◽  
Georg Brabant
Keyword(s):  
Thyroid Carcinoma ◽  
Potential Role ◽  
Hypoxia Inducible Factor ◽  
Current Data ◽  
Low Oxygen ◽  
Expression Of Genes ◽  
Mitogen Activated Protein ◽  
Growth Factor Signalling ◽  
Pi3k Signalling

Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy. In addition to hypoxia, HIF-1 can be activated by growth factor-signalling pathways such as the mitogen-activated protein kinases- (MAPK-) and phosphatidylinositol-3-OH kinases- (PI3K-) signalling cascades. Mutations in these pathways are common in thyroid carcinoma and lead to enhanced HIF-1 expression and activity. Here, we summarise current data that highlights the potential role of both hypoxia and MAPK/PI3K-induced HIF-1 signalling in thyroid carcinoma progression, metastatic characteristics, and the potential role of HIF-1 in thyroid carcinoma response to radiotherapy. Direct or indirect targeting of HIF-1 using an MAPK or PI3K inhibitor in combination with radiotherapy may be a new potential therapeutic target to improve the therapeutic response of thyroid carcinoma to radiotherapy and reduce metastatic burden.

scholarly journals IUGR impairs cardiomyocyte growth and maturation in fetal sheep

2018 ◽  
Vol 239 (2) ◽  
pp. 253-265 ◽  
Author(s):  
Sonnet S Jonker ◽  
Daniel Kamna ◽  
Dan LoTurco ◽  
Jenai Kailey ◽  
Laura D Brown
Keyword(s):  
Cell Cycle ◽  
Skeletal Muscle ◽  
Cell Cycle Regulation ◽  
Striated Muscle ◽  
Placental Insufficiency ◽  
Growth Restriction ◽  
Fetal Sheep ◽  
Ambient Temperatures ◽  
Expression Of Genes ◽  
Cycle Regulation

Placental insufficiency causes intrauterine growth restriction (IUGR), a common complication of pregnancy. In skeletal muscle, IUGR reduces fetal myofibril size, reduces myoblast proliferation and reduces expression of genes in cell cycle regulation clusters. The myocardium is striated like skeletal muscle, and IUGR also reduces cell cycle activity and maturation in cardiomyocytes, despite cardiac output preferentially directed to the coronary circulation. We hypothesized that cardiomyocyte growth restriction would be accompanied by similar changes in cell cycle regulation genes and would reduce cardiomyocyte cell cycle activity, number, maturity and size. Pregnant ewes were housed in elevated ambient temperatures from ~40 to ~115 days of gestation (dGA) to produce placental insufficiency and IUGR; fetal hearts were studied at ~134 dGA. Hearts were biopsied for mRNA analysis and then dissociated into individual myocytes (Control n = 8; IUGR n = 15) or dissected (Control n = 9; IUGR n = 13). IUGR fetuses had low circulating insulin and insulin-like growth factor 1 (IGF1) and high circulating cortisol. Bodies and hearts of IUGR fetuses were lighter than those of Controls. Cardiomyocytes of IUGR fetuses were smaller, less mature, less active in the cell cycle and less numerous than in Controls. Further, there was a pattern of downregulation of cell cycle genes in IUGR ventricles. IUGR growth profiles in heart and skeletal muscle suggest similar regulation despite differences in blood and nutrient delivery prioritization. IGF1 signaling is suggested as a mechanism regulating altered growth in IUGR striated muscle and a potential therapeutic candidate.

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