scholarly journals ANTIMULLERIANHORMONE: CORRELATION WITH FIRST TRIMESTER MISCARRIAGE

2021 ◽  
Vol 9 (01) ◽  
pp. 886-891
Author(s):  
Mostafa Abdulla Elsayed ◽  
Keyword(s):  
Pregnancy Loss ◽  
Cardiac Activity ◽  
First Trimester ◽  
Assisted Conception ◽  
Statistical Software ◽  
Blood Samples ◽  
Spontaneous Pregnancy ◽  
Valuable Marker ◽  
First Trimester Of Pregnancy ◽  
Early Abortion

Objective: The present study assessed antiMullerian hormone (AMH) levels as a useful markerand a predictor of abortion in the first trimester among women younger than 35 years. Methods: Prospective study of women aged 18–34 years with a spontaneous pregnancy at less than 12 gestational weeks in Benha , Egypt, between January 2019 and November 2020 samples of blood taken at the beginning of pregnancy on booking and again at 6 weeks. Cases of anembryonic abortion and assisted conception were excluded. Blood samples were collected and assayed for serum AMH levels (on booking and at 6 weeks gestation. Data were compared between women with an embryo with no cardiac activity by ultrasound (n=50) and those with a normalpulsating embryo (n=50) by using smith statistical software. Results: Risk of pregnancy loss in the first trimester was found to be higher for low AMH (<1 ng/mL relative risk [RR], 3.66 95% confidence interval. Conclusions: LowAMH concentrations found to significantly increase the risk of abortion in the first trimester of pregnancy. Serum AMH might be a valuable marker to predict the risk of early abortion when it is below 1ng/ml.

scholarly journals Distribution of diandric and digynic triploidy depending on gestational age

2021 ◽  
Author(s):  
Diana Massalska ◽  
Katarzyna Ozdarska ◽  
Tomasz Roszkowski ◽  
Julia Bijok ◽  
Anna Kucińska-Chahwan ◽  
...  
Keyword(s):  
Gestational Age ◽  
Pregnancy Loss ◽  
First Trimester ◽  
Parental Origin ◽  
Second Trimester ◽  
Chain Reaction ◽  
Spontaneous Pregnancy ◽  
First Trimester Of Pregnancy ◽  
Polymerase Chain ◽  
Fluorescent Polymerase Chain Reaction

Abstract Purpose To establish the distribution of diandric and digynic triploidy depending on gestational age. Methods 107 triploid samples tested prospectively in a single genetic department during a four-year period were analyzed for parental origin of triploidy by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) (n=95) with the use of matching parental samples or by MS-MLPA (n=12), when parental samples were unavailable. Tested pregnancies were divided into three subgroups with regard to the gestational age at spontaneous pregnancy loss: <11 gestational weeks, 11–14 gestational weeks, and >14 gestational weeks. Results Diandric triploidy constituted overall 44.9% (46.5% in samples miscarried <11 gestational weeks, 64.3% in samples miscarried between 11 and 14 gestational weeks, and 27.8% in pregnancies which survived >14 gestational weeks). Conclusions The distribution of diandric and digynic triploidy depends on gestational age. The majority of diandric triploid pregnancies is lost in the first trimester of pregnancy. In the second trimester, diandric cases are at least twice less frequent than digynic ones.

scholarly journals Hydroxychloroquine and the Prevention of Pregnancy Losses

2019 ◽  
pp. 359-366
Author(s):  
Frishman M ◽  
Radin M ◽  
Cecchi I ◽  
Sciascia S ◽  
Schreiber K
Keyword(s):  
Connective Tissue ◽  
Antiphospholipid Antibodies ◽  
Pregnancy Loss ◽  
Chromosomal Abnormalities ◽  
Connective Tissue Diseases ◽  
First Trimester ◽  
Pregnancy Complication ◽  
Distinct Entity ◽  
Consecutive Pregnancy ◽  
First Trimester Of Pregnancy

Pregnancy loss is a common and devastating pregnancy complication. Recurrent early miscarriage (REM) isdefined as two or more consecutive pregnancy losses during the first trimester of pregnancy. It is a distinct entity and in approximately 50% of these patients, the underlying cause is never established. REM can be idiopathic, i.e. of unknown cause, be related to infections, anatomical or chromosomal abnormalities and can also be related to the presence of autoimmune connective tissue diseases or antiphospholipid antibodies (aPL). Hydroxychloroquine (HCQ) is an antimalarial immunomodulator and is currently being investigated for its role in the prevention of idiopathic REM and REM related to antiphospholipid antibodies (aPL). In this article we review the evidence that exists to date regarding the use of HCQ in the setting of unexplained REM and REM in relation to connective tissue diseases and aPL and antiphospholipid syndrome (APS).

scholarly journals Efficiency of early monitoring gestational process in women with risk of pregnancy loss

2021 ◽  
Vol 51 (4) ◽  
pp. 8-12
Author(s):  
V. E. Radzinskiy ◽  
E. M. Demidova ◽  
M. Y Bazovaia ◽  
I. M. Ordiyants
Keyword(s):  
Enzyme Activity ◽  
Blood Plasma ◽  
Pregnant Women ◽  
Pregnancy Loss ◽  
First Trimester ◽  
First Trimester Of Pregnancy ◽  
Definition Of

This article is devoted to optimization of dispensary observation at the eshlia terms of gestation of women suffer from sporadic miscaniages in anamnesis as well as tlie definition of prognostic meaning of the ultmsonic doppleromet-ry criterias, the enzyme activity of lisosomal of blood plasma and tlie cytochemical mte (DCR) for tlie segmentnuclear leucocytes at the pregnant women witli pathological obstetl'ic anamnesis. 13 7p1-egnant women were tested, 98 o f them at the earlier terms o f gest-ation from 7 to 14 weelis of t-heir pregnancy. The received data show that metabolic conection and normalization of microbiocenosis of vagina and cavix channel in tlie first trimester of pregnancy is pathogen validity, they promot-e tlie nmwaf pregnancy of the next terms of gestation and decrease tlie frequency of repeat-ed misriages

scholarly journals EMBRYONIC HEART RATE: A PROGNOSTIC FACTOR OF FIRST TRIMESTER PREGNANCY OUTCOME

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Chetana Choudhary ◽  
Lata Rajoria ◽  
Chelsae Kuntal ◽  
Sunita Hemani ◽  
Aditi Bansal ◽  
...  
Keyword(s):  
Heart Rate ◽  
Gestational Age ◽  
Pregnancy Loss ◽  
Cardiac Activity ◽  
First Trimester ◽  
Good Prognosis ◽  
Embryonic Heart ◽  
Transvaginal Sonography ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

Introduction: The earliest proof of a viable pregnancy is obtained when cardiac activity of the embryo can be observed. Transvaginal sonography can accurately demonstrate embryonic heart rate at 6 weeks of gestational age by using M-mode transvaginal sonography. Slow embryonic heart rate at 6-7 weeks of gestational age is associated with high rate of first trimester pregnancy loss. AIM:  The study was aimed to evaluate the role of embryonic heart rate (EHR) of early pregnancies as predictive factor of adverse outcome at end of first trimester of pregnancy. Methods: This observational study was conducted in the Department of Obstetrics and Gynecology Zenana Hospital, SMS Medical College, Jaipur. It included 300 pregnant women between 6 weeks to 9 weeks of gestational age attending antenatal OPD. Embryonic heart rate was measured by transvaginal sonography. Embryonic heart rate was classified as slow, if it was fewer than 110 beats/ mint or outcome was measured as occurance of spontaneous pregnancy loss prior to 12 weeks. Results: Out of 300 cases, 290 (96.67%) had embryonic heart rate ?100 beats per minutes and 10(3.33%) had embryonic heart rate <100 beats per minutes. Out of these 290, (Embryonic heart rate ?100 beats per minutes), 284 (97.93%) had good prognosis and 6 (2.07%) had abortion. In 10 women (Embryonic heart rate <100 beats per minutes), 3 (30.00%) had good prognosis and 7 (70.00%) had abortion. This observation was statistically significant. Conclusion: Slow embryonic heart rate on ultrasonography reduced the success of pregnancy and may lead to abortion. Keywords: Embryonic heart rate, Ultrasonography, Early pregnancy loss

scholarly journals Increased Pregnancy Loss Rate in Thyroid Antibody Negative Women with TSH Levels between 2.5 and 5.0 in the First Trimester of Pregnancy

2010 ◽  
Vol 95 (9) ◽  
pp. E44-E48 ◽  
Author(s):  
Roberto Negro ◽  
Alan Schwartz ◽  
Riccardo Gismondi ◽  
Andrea Tinelli ◽  
Tiziana Mangieri ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Loss Rate ◽  
First Trimester ◽  
Thyroid Antibody ◽  
First Trimester Of Pregnancy ◽  
Tsh Levels

Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment

2006 ◽  
Vol 291 (5) ◽  
pp. E878-E884 ◽  
Author(s):  
Waljit S. Dhillo ◽  
Philip Savage ◽  
Kevin G. Murphy ◽  
Owais B. Chaudhri ◽  
Michael Patterson ◽  
...  
Keyword(s):  
Reproductive Development ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Gestational Trophoblastic Neoplasia ◽  
Third Trimester ◽  
Blood Samples ◽  
Amino Acid Peptide ◽  
The Third ◽  
First Trimester Of Pregnancy ◽  
G Protein Coupled

Kisspeptin is a 54-amino acid peptide, encoded by the anti-metastasis gene KiSS-1, that activates G protein-coupled receptor 54 (GPR54). The kisspeptin-GPR54 system is critical to normal reproductive development. KiSS-1 gene expression is increased in the human placenta in normal and molar pregnancies. Circulating kisspeptin is dramatically increased in normal pregnancy, but levels in GTN have not previously been reported. The present study was designed to determine whether plasma kisspeptin levels are altered in patients with malignant GTN. Thirty-nine blood samples were taken from 11 patients with malignant GTN at presentation during and after chemotherapy. Blood was also sampled from nonpregnant and pregnant volunteers. Plasma kisspeptin IR and hCG concentrations were measured. Plasma kisspeptin IR concentration in nonpregnant ( n = 16) females was <2 pmol/l. Plasma kisspeptin IR in females was 803 ± 125 pmol/l in the first trimester of pregnancy ( n = 13), 2,483 ± 302 pmol/l in the third trimester of pregnancy ( n = 7), and <2 pmol/l on day 15 postpartum ( n = 7). Plasma kisspeptin IR and hCG concentrations in patients with malignant GTN were elevated at presentation and fell during and after treatment with chemotherapy in each patient (mean plasma kisspeptin IR: prechemotherapy 1,363 ± 1,076 pmol/l vs. post-chemotherapy <2 pmol/l, P < 0.0001; mean plasma hCG: prechemotherapy 227,191 ± 152,354 U/l vs. postchemotherapy 2 U/l, P < 0.0001). Plasma kisspeptin IR strongly positively correlated with plasma hCG levels ( r2= 0.99, P < 0.0001). Our results suggest that measurement of plasma kisspeptin IR may be a novel tumor marker in patients with malignant GTN.

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