scholarly journals IMPACTS OF THE FOOD ADDITIVE BENZOIC ACID ON LIVER FUNCTION OF WISTAR RATS.

2016 ◽  
Vol 4 (8) ◽  
pp. 568-575
Author(s):  
Mahmoud.M. Hassan ◽  
◽  
MuawiaI.A.Abdelgadir Elrrigieg ◽  
MurwanK. Sabahelkhier ◽  
OmerF. Idris. ◽  
...  
Keyword(s):  
Liver Function ◽  
Benzoic Acid ◽  
Wistar Rats ◽  
Food Additive

scholarly journals ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF SWERTIA CHIRATA ON HYPOXIA-INDUCED OXIDATIVE STRESS IN WISTAR RATS

2019 ◽  
Vol 12 (1) ◽  
pp. 76
Author(s):  
Kritika Kaushal ◽  
Harvinder Singh ◽  
Anil Kant Thakur
Keyword(s):  
Oxidative Stress ◽  
Liver Function ◽  
Wistar Rats ◽  
Hepatic Damage ◽  
Ros Generation ◽  
Dependent Manner ◽  
Traditional Use ◽  
Hydroalcoholic Extract ◽  
Swertia Chirata ◽  
Liver Functions

Objective: Swertia chirata has been used in traditional and folklore medicine to treat several ailments such as hepatic disorders. However, the mechanistic and experimental justification to its traditional use is lacking. The present study was aimed to investigate the hepatoprotective potential of S. chirata during hypoxia (HYP)-induced hepatic damage in Wistar rats and to determine the underlying mechanism.Methods: Hydroalcoholic extract of S. chirata was prepared using Soxhlet extraction. Animals were divided into six groups (n=5). Animals in the HYP groups were subjected to HYP for 3 days (10% O2) to induce oxidative stress and hepatic damage. 50 and 100 mg/kg extract treatments were provided orally once daily for 7 days after which animals were sacrificed, and biochemical investigations for oxidative stress, liver function tests, and hepatic histopathology were performed.Results: HYP-induced marked oxidative stress as indicated by the significantly elevated mitochondrial ROS generation, lipid peroxidation, glutathione, and depleted catalase levels. Liver function test indicated hepatic damage as the levels of serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, and aspartate transaminase were significantly elevated in HYP animals. S. chirata treatment alleviated oxidative stress and improved liver functions in a dose-dependent manner. Liver histopathology confirmed the marked hepatic damage induced by HYP and revealed that S. chirata efficiently rescued liver from hypoxic damage.Conclusion: Hydroalcoholic extract of S. chirata is a potent hepatoprotective intervention which was associated with its potential to alleviate oxidative stress and improve liver functions. Moreover, it could find clinical application as a safer and alternative remedy for liver ailments.

scholarly journals Protective effect of Berberis asiatica root on biochemical and histopathological changes in streptozotocin-induced diabetic Wistar rats

2017 ◽  
Vol 6 (8) ◽  
pp. 1880 ◽  
Author(s):  
Mohd Muddassir Husain Khan ◽  
Chetan Rastogi ◽  
Sachin Gupta ◽  
Shravan Kumar Paswan ◽  
Pritt Verma ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Liver Function ◽  
Blood Glucose Level ◽  
Protective Effect ◽  
Glucose Level ◽  
Wistar Rats ◽  
Total Bilirubin ◽  
Group Iv ◽  
Group Iii ◽  
Group I

Background: This study was designed to evaluate the effect of Berberis asiatica root extract (BAE) against streptozotocin induced elevated blood glucose level and other liver and kidney functions changes in adult male Wistar rats.Methods: Thirty male Wistar rats were divided into five groups of six rats in each (Groups I-V). Group I and Group II served as normal control and disease control, respectively. Group III received standard anti-diabetic drug glibenclamide (5mg/kg), while Group IV and Group V received the low dose (250mg/kg) and high dose (500mg/kg) of BAE. Serum blood glucose, SGOT, SGPT, ALP, total bilirubin, BUN, serum creatinine, TC, TG, HDL-C, LDL-C, and VLDL-C were estimated using standard methods. After collection of samples for biochemical evaluation, the pancreas from each animal was isolated and examined for histological changes.Results: BAE and glibenclamide treated disease rats showed significant (p <0.05) decrease in blood glucose concentration. Treatment with BAE at 250mg/kg and 500mg/kg in Group IV and V and standard drug glibenclamide in Group III showed significant (p <0.05) reduction in the level of liver function substances such as SGOT, SGPT, ALP and total bilirubin as compared to disease group, as well as showed significant (p <0.05) decrease in renal panel. Liver function parameters were significantly (p <0.05) improved in groups treated with BAE. Histopathological analysis revealed the protective effect of BAE against streptozotocin induced damage to islets of Langerhans.Conclusions: This study showed the destruction of islets of Langerhans and elevation in blood glucose level as well as alteration in other biochemical parameters were ameliorated by the effect of Berberis asiatica extract.

scholarly journals STUDY ON FRESH LEAF AQUEOUS EXTRACT OF FLACOURTIA INDICA FOR HEPATOPROTECTIVE, ANTI-ANEMIC AND HYPOGLYCEMIC ABILITIES IN CCL4 INDUCED HEPATOTOXICITY IN ALBINO WISTAR RATS

2019 ◽  
Author(s):  
Idoko A ◽  
Ufedo-Enyo G. Emmanuel
Keyword(s):  
Blood Glucose ◽  
Liver Function ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Hepatic Injury ◽  
Negative Control ◽  
Herbal Remedies ◽  
Fresh Leaf ◽  
Group I ◽  
Leaf Aqueous Extract

Hepatic injury and its associated conditions have been reportedly shown to be managed through herbal remedies. In this study, investigation of the fresh leaf aqueous extract of Flacourtia indica (of the family of Salicaceae) as hypoglycemic, anti-anemic and hepatoprotective agent in albino wistar rats induced CCl4 hepatotocxicity was done. Fifteen rats of either sex, weighing 175-295g, divided into five groups (I-V) of three rats each, were used. Group-I is negative control, II-positive control and III –V test groups. Groups II-V were induced 200mg/Kg/bodyweight CCl4, for 3-days, for hepatic injury and anemia. Groups III-V were respectively treated orally with 400, 600 and 800 mg/Kg/bodyweight of fresh leaf aqueous extracts (FLAE) of Flacourtia indica, for 7-days. Activities of Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase, concentrations of Bilirubin, Albumin, Total protein, blood glucose and packed cell volume (PCV) and hemoglobin were assayed. Results after induction showed significant (p˂0.05) decrease in heamoglobin and PCV, significant (p˂0.05) increase in the liver function enzymes and blood glucose compared with results of liver function enzyme and blood glucose having significant (p˂0.05) decrease, and significant (p˂0.05) increase of PCV and hemoglobin after treatment with FLAE of Flacourtia indica. Body weight of rats induced CCl4 was found to increase with FLAE of Flacourtia indica treatment. It may be concluded that the potentials exhibited by FLAE of Flacourtia indica to manage hyperglycaemia, hepatic injury and anemia induced by CCl4 are associated with its antioxidant activity and the presence of phytochemicals, minerals and nutrients value.

scholarly journals Hepatotherapeutic Tendency of Citrullus lanatus Rind Methanolic Extract on Liver Markers in Male Wistar Rats

2019 ◽  
pp. 1-10
Author(s):  
Ilochi Ogadinma ◽  
Chuemere Arthur Nwafor ◽  
Bassy Samuel
Keyword(s):  
Liver Function ◽  
Wistar Rats ◽  
Liver Enzymes ◽  
Methanolic Extract ◽  
Citrullus Lanatus ◽  
Left Ventricular ◽  
Normal Male ◽  
High Dose ◽  
Serum Total Bilirubin ◽  
Male Wistar Rats

It is a common practice to dispose the peel or rind of fruits. Interestingly, some parts of fruits humans find unacceptable to eat actually possess bioactive nutrients that can be used for medicinal purposes.  The effect of methanolic extract of Citrullus lanatus rind on liver function in normal male wistar rats was studied. 24 wistar rats with body weight between 150-250 g were used for this study. The animals were randomly divided into four groups, with 6 rats in each. Group 1 contained the control given normal saline and feed; group 2, low dose, 50mg/kg of methanolic extract of  Citrullus lanatus rind was administered, group 3 and 4 were administered medium and high dose of Citrullus lanatus rind extract 100 mg/kg and 200 mg/kg respectively. The Citrullus lanatus rind extract was administered via orogastric route and the experiment lasted for a period of 56 days. Blood samples were collected by left ventricular cardiac puncture for liver function test at the last day of the experiment.  The outcome of this research revealed that medium and high dose administration of citrullus lanatus rind significantly (p≤0.05) reduced the serum level of liver enzymes alanine transaminase, aspartate transaminase and alkaline phosphatase and also total protein.There was a non-significant (P≤0.05) change in serum total bilirubin and albumin when all doses were compared to the control. Prolonged and moderate ingestion of Citrullus lanatus rind may be of benefit in regulating blood level of liver enzymes; hence, this part of the fruit has therapeutic value.

scholarly journals The effect of rutin on lipid profile and liver function enzymes on alloxan induced hyperglycaemic wistar rats

2017 ◽  
Vol 10 (1) ◽  
pp. 210
Author(s):  
Y Tanko ◽  
A Jimoh ◽  
I Sulaiman ◽  
K.A. Mohammed ◽  
A.I. Salisu ◽  
...  
Keyword(s):  
Liver Function ◽  
Lipid Profile ◽  
Wistar Rats
Sign in / Sign up

Export Citation Format

Share Document