scholarly journals Perinatal outcomes of newborns born from young mothers with epidural analgesia

2021 ◽  
Vol 66 (3) ◽  
pp. 118-124
Author(s):  
R. T. Shakirov ◽  
S. V. Kinzhalova ◽  
R. A. Makarov ◽  
S. V. Bychkova ◽  
N. V. Putilova ◽  
...  
Keyword(s):  
Epidural Analgesia ◽  
Cord Blood ◽  
Young Women ◽  
Neonatal Period ◽  
Young Mothers ◽  
Acid Base ◽  
Term Infants ◽  
Early Neonatal Period ◽  
Arterial Blood

Objective. To evaluate the features of the course of the early neonatal period of newborns born from young women under conditions of epidural analgesia.Material and methods. The authors conducted a prospective, comparative, randomized, longitudinal, monocenter study. Patients of Group 1 (n=25) were anesthetized with a narcotic analgesic (2% Тrimeperedine 1,0 ml intramuscularly). Patients of Group 2 (n=30) received long-term epidural analgesia (EA) with 0,2% Ropivacaine (10,0 ml/hour). All patients delivered full-term infants. The course of labor, clinical and laboratory characteristics of newborns in the early neonatal period were evaluated.Results. There were no significant differences in the duration of labor, volume of blood loss, and other characteristics between the groups. There were no clinical differences between the groups of newborns. We did not find a negative effect of epidural analgesia on the Apgar score at the 1st (p=0,166) and 5th (p=0,217) minutes of life and the neuropsychiatric status of the newborn (p=0,322). At the same time, in the group of long-term epidural analgesia, there was a tendency to a higher incidence of moderate and mild asphyxia (19,2% versus 9,5%; p=0,436). When comparing the acid-base state of umbilical cord arterial blood, significant differences were found in the following indicators: lower pH (p=0,042) and pO2 level (p=0,007) and higher pCO2 level (p=0,031) in arterial cord blood.Conclusion. Epidural analgesia during labor in young women is accompanied by a lower level of pH and pO2 and a higher level of pCO2 in the arterial cord blood as compared to a Group of Тrimeperedine, which indicates a more pronounced shift in the acid-base state of the fetal blood. When analyzing neurological outcomes in newborns, there were no statistically significant differences. However, further follow-up is required for children born from young mothers who have received long-term epidural analgesia in labor.

scholarly journals FEATURES OF PREGNANCY AND DELIVERY IN ADOLESCENT WOMEN

2021 ◽  
Vol 21 (3) ◽  
pp. 117-122
Author(s):  
O.S. Shkolnyk ◽  
O.K. Yefimenko ◽  
O.M. Malanchuk ◽  
L.M. Melenchuk ◽  
Ye.B. Sharhorodska
Keyword(s):  
At Risk ◽  
Young Women ◽  
Neonatal Period ◽  
Significant Proportion ◽  
Control Group ◽  
Young Mothers ◽  
Perinatal Complications ◽  
Adolescent Women ◽  
Early Neonatal Period ◽  
Complicated Pregnancy

Aim: to assess the risk of adverse consequences of adolescent pregnancy for mother and foetus in women from Lviv region. Material and methods. Complications of pregnancy and childbirth in adolescent women were studied retrospectively at the Lviv Regional Clinical Hospital. Results and discussion. 134 cases of adolescent childbirths for 2013 to 2017 were analyzed. The analysis of data on the course of pregnancy in adolescent women showed that the vast majority of them had complicated pregnancy and were at risk of preterm childbirth. A significant proportion of young women, 78 (58.2%), significantly more often required the therapy during pregnancy. Assessment of the health status of newborns showed that ¼ (24.6%) of young women gave birth to premature babies, and almost 1/3 of children, 51 (38.0%), from young mothers had a complicated early neonatal period. Within the spectrum of complications, the commonest diagnosis was "prematurity" in 33 (24.6%) children from young mothers. The pathological course of the early neonatal period in 51 (38.0%) children of the main group required transfer to other departments for further treatment. 82 (61.2%) children from this group were discharged home, while in the control group all 100 (100.0%) children were discharged from maternity home. Conclusions. The study has demonstrated that the risk factors for perinatal pathology in newborns from adolescent women included probably complicated pregnancy, risk of spontaneous abortion (17.9%), preterm birth (24.6%), and the childbirth of premature infants with impaired condition at birth, who needed treatment in other medical institutions (38.0%). Adolescent pregnant women are at risk for obstetric and perinatal complications.

Creatine kinase isoenzymes in serum from cord blood and the blood of healthy full-term infants during the first three postnatal days.

1982 ◽  
Vol 28 (2) ◽  
pp. 317-322 ◽  
Author(s):  
R Jedeikin ◽  
S K Makela ◽  
A T Shennan ◽  
R D Rowe ◽  
G Ellis
Keyword(s):  
Creatine Kinase ◽  
Cord Blood ◽  
Vaginal Delivery ◽  
Neonatal Period ◽  
Full Term ◽  
Term Infants ◽  
Skin Puncture ◽  
Creatine Kinase Isoenzymes ◽  
Cesarian Section

Abstract Isoenzymes of creatine kinase (ATP:creatine phosphotransferase; EC 2.7.3.2; CK) were measured by electrophoresis in serum from cord blood and skin-puncture blood taken from 45 healthy full-term infants during the first three postnatal days. Mean total CK activities (in U/L at 30 degrees C) were 185 in cord samples, 536 in samples taken between 5--8 h postnatally, 494 between 24--33 h, and 288 in the 72-100 h samples. Values for all three isoenzymes increased to a peak over this period, with the highest values generally being found in the samples taken 5--33 h after birth; the subsequent decline was most rapid for CK-BB. Serum CK isoenzymes in cord samples and those taken at 72--100 h in the 11 babies delivered by cesarian section did not differ significantly from those of babies delivered vaginally. However the postnatal increases in total CK, CK-MM, and CK-MB (but not in CK-BB) were significantly greater in those patients born by vaginal delivery. The reasons for the increases in CK isoenzymes after birth are not clear, but our results and reported studies on the ontogeny of CK suggest that CK-MB cannot be regarded as a "cardiac-specific" isoenzyme in the neonatal period.

Umbilical cord blood acid-base balance and gas composition in relation to the use of epidural analgesia in vaginal delivery

2019 ◽  
Vol 5_2019 ◽  
pp. 70-76
Author(s):  
Tysyachnyy O.V. Tysyachnyy ◽  
Baev O.R. Baev ◽  
Evgrafova A.V. Evgrafova ◽  
Prikhodko A.M. Prikhodko ◽  
Pismensky S.V. Pismensky S ◽  
...  
Keyword(s):  
Epidural Analgesia ◽  
Cord Blood ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gas Composition ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

scholarly journals The repercussions of reduced energy and protein intake during the early neonatal period of very-low-birth-weight infants on their lung function during childhood

2020 ◽  
Author(s):  
José Uberos Fernández ◽  
YOLANDA Gónzalez Jimenez ◽  
Ana Campos-Martínez ◽  
María Tejerizo-Hidalgo ◽  
Elizabeth Fernández-Marín ◽  
...  
Keyword(s):  
Birth Weight ◽  
Lung Function ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neonatal Period ◽  
Low Birth Weight Infants ◽  
Early Neonatal Period ◽  
Protein Energy ◽  
Z Scores

Background Prematurity and bronchopulmonary dysplasia can modify lung function in children and adults. Postnatal nutrition and rapid growth catch-up may influence the long-term development of lung function. Methods This prospective observational study was based on a cohort of 334 very-low-birth-weight (VLBW) neonates, born between 1 January 2008 and 12 December 2015. Patients with severe neurological damage, death or incomplete data record were excluded. When these infants reached a mean age of 7.7 years, a spirometry evaluation was performed, to determine FEV1, FEF25-75%, FVC and the FEV1/FVC ratio. The relation between these parameters and nutritional intake in the early neonatal period was determined by regression analysis. Results In total, 40 spirometry tests were performed. The results obtained, after adjusting for age and sex by Z-scores for the spirometry variables, showed that the schoolchildren who had been VLBW recorded significantly lower spirometry results (FVC, FEV1, FEF25-75%) than the reference values. Furthermore, there was a significant association between the FEV1/FVC ratio and the intake of macronutrients and energy in the first week of life. It is hypothesised that increasing energy intake and achieving a higher protein/energy ratio in the first week of life would improve the FEV1/FVC ratio by the time these VLBW infants reach school age. Conclusions Active nutritional management in the early neonatal period is associated with improved lung function, as reflected by the spirometry findings obtained.

scholarly journals Acid-base status and cardiovascular function in mink (Mustela vison) anaesthetized with ketamine/midazolam

1996 ◽  
Vol 30 (1) ◽  
pp. 55-66 ◽  
Author(s):  
S. Wamberg ◽  
P. Svendsen ◽  
B. Johansen
Keyword(s):  
Heart Rate ◽  
Sodium Bicarbonate ◽  
Isotonic Saline ◽  
Cardiovascular Function ◽  
Spontaneous Respiration ◽  
Acid Base ◽  
Arterial Blood ◽  
Intravenous Solution ◽  
Acid Base Status

Heart rate, arterial blood pressure and blood acid-base status were determined in 18 adult female mink (mean (±SEM)body weight 1052±34 g)during long-term anaesthesia with either controlled ventilation ( n=12) or spontaneous respiration ( n=6) Surgical anaesthesia was induced by intramuscular injection of ketamine hydrochloride (Ketaminol Vet®, 40.0±1.7mg/kg) and midazolam hydrochloride (Dormicum® 2.8±0.1 mg/kg) and maintained for at least 5 h by continuous intravenous infusion of this drug combination in 0.9% saline. For all animals, the mean rates of infusion of ketamine and midazolam were 48.4±1.6 and 1.61±0.12 mg/h, respectively. Following continuous infusion of the anaesthetics in isotonic saline, at a rate of 20 ml/h, a moderate 'dilution acidosis' developed, which could be corrected by replacement of part of the saline with sodium bicarbonate to a final concentration of approximately 25 mmol NaHCO3 per litre. However, when the animals were allowed to breathe spontaneously, an increase in heart rate and a combined respiratory and metabolic acidosis occurred, due to severe respiratory depression. Apart from these effects and a few cases of increased salivation, no adverse effects over time were observed on the arterial blood acid-base status and cardiovascular function of the animals during ketamine/midazolam anaesthesia. It is concluded that the procedure described for long-term anaesthesia in mink is convenient and safe for acute physiological experiments in this species, provided normal body temperature and pulmonary gas exchange is sufficiently maintained. Thus, the need for an adequately controlled artificial ventilation is strongly emphasized. Finally, a proposal for the composition of an intravenous solution, containing ketamine and midazolam hydrochloride, and sodium bicarbonate in saline, suitable for long-term anaesthesia in adult mink is presented.

Two full-term infants with Chlamydia trachomatis pneumonia in the early neonatal period

1998 ◽  
Vol 157 (11) ◽  
pp. 950-951 ◽  
Author(s):  
Y. Niida ◽  
K. Numazaki ◽  
M. Ikehata ◽  
M. Umetsu ◽  
H. Motoya ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Neonatal Period ◽  
Full Term ◽  
Term Infants ◽  
Early Neonatal Period
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