scholarly journals Food protein-induced enteropathy and its complications

2021 ◽  
Vol 66 (5) ◽  
pp. 135-140
Author(s):  
G. N. Yankinа ◽  
L. V. Gorlenko ◽  
E. V. Loshkova ◽  
E. I. Kondratyeva ◽  
A. A. Terentyeva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Patient Management ◽  
Clinical Case ◽  
Underlying Disease ◽  
Diet Therapy ◽  
Deficiency Anemia ◽  
Food Protein ◽  
Pediatric Practice ◽  
B12 Deficiency

Currently, in pediatric practice, a special place is occupied by patients with severe allergic lesions of the gastrointestinal tract, which often manifest immediately after the birth of a child. Food protein-induced enteropathy reduces the quality of life of the child and family; it is difficult to diagnose and to treat. We present a clinical case of a patient with food protein-induced enteropathy, complicated by severe B12-deficiency anemia and edema syndrome. In the tactics of patient management, attention is paid to the late diagnosis of the underlying disease and complications, the complexity of prescribing diet therapy and the lack of alertness regarding the diagnosis of malabsorption associated with food intolerance.

scholarly journals Anemia of chronic diseases as an interdisciplinary problem

2021 ◽  
Vol 40 (2) ◽  
pp. 55-61
Author(s):  
Sergey V. Bondarchuk ◽  
Konstantin P. Golovko ◽  
Dmitriy V. Ovchinnikov
Keyword(s):  
Quality Of Life ◽  
Iron Deficiency ◽  
Chronic Diseases ◽  
Great Part ◽  
Underlying Disease ◽  
Current Data ◽  
Deficiency Anemia ◽  
Pulmonary Insufficiency ◽  
Target Values

Anemia is believed to be a medico-social problem affecting a great part of population. Anemia of chronic diseases represents a considerable number of these disorders, which is particularly challenging for long-standing inflammatory processes, systemic diseases and neoplasms. Pathogenesis of this type of anemia is characterized by complex and miltifactorial nature. Pathogenesis is based on disturbance of erythropoietin synthesis and erythropoiesis precursor cells sensitivity, hyperproduction of factors inhibiting erythropoiesis (tumor necrosis factor, interleukins), disturbance of iron metabolism and other hemopoiesis co-factors. Anemia aggravates associated underlying disease course. Quality of life and overall survival deteriorate. Treatment efficacy for anemia influences the time of patient recovery, as well as success of treatment of other diseases. Iron deficiency and erythropoiesis disturbance, similar to hypoferric anemia, are of great importance. However, iron therapy may aggravate patients condition, hence differential diagnosis of this anemia type and true iron deficiency anemia has a great practical value. In the treatment of anemia in the presence of chronic diseases and anemia in the presence of hematologic diseases, the goal of the treatment is generally limited by the improvement of patients quality of life, target value of hemoglobin for transfusion or erythropoiesis stimulating therapy remaining the subject for discussion. Hemoglobin target determination in individuals with cardiac and pulmonary insufficiency who are on chemotherapy, is critically important, because it is this category of patients that does not demonstrate generally accepted target values of hemoglobin, the level of which is not always indicative of hypoxia absence. The review presents current data on diagnosis, treatment of chronic disease anemia (1 figure, 2 tables, bibliography: 12 refs).

Clinical case of a comorbid patient with arterial hypertension

2020 ◽  
pp. 31-39
Author(s):  
Ella Polozova ◽  
Vsevolod Skvortsov ◽  
Olga Radaykina ◽  
Mariya Narvatkina ◽  
Anastasiya Seskina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Picture ◽  
Clinical Case ◽  
Diagnosis And Treatment ◽  
The Moment

The widespread prevalence of comorbid pathology determines the relevance of this problem. Comorbid pathology due to the interaction of diseases, drug pathomorphism, age characteristics of the patient, significantly changes clinical picture and course of the main nosology, affects severity of complications and their nature, significantly affects quality of life and prognosis of patients. Diagnosis and treatment of many diseases is complicated in the conditions of comorbidity. The article presents a clinical case of a comorbid patient with arterial hypertension from the moment of exposure to risk factors and ending with the formation of many concomitant diseases, as an example of trans-nosological comorbidity.

CLINICAL CASE: STEROID-RESISTANT NEPHROTIC SYNDROME

2021 ◽  
pp. 13-17
Author(s):  
А.Е. Турсын
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Arterial Hypertension ◽  
Clinical Case ◽  
Steroid Resistant ◽  
Steroid Resistant Nephrotic Syndrome ◽  
Moderate Severity ◽  
Syndrome Diagnosis ◽  
Pathogenetic Therapy

Описан клинический случай пациент с нефротическим синдромом, стероид резистентный вариант, с артериальной гипертензией, осложненный полисерозитом (гидроторакс, асцит, плеврит). Пациент поступил в клинику в состоянии средней степени тяжести, с массивными отеками, полисерозитом, артериальной гипертензией и выраженным нефротическим синдромом. Диагноз: Гломерулярная болезнь. Нефротический синдром, стероид резистентный вариант. Функция почек снижена (СКФ- 84мл/мин по Шварцу). Двухсторонний экссудативный плеврит. Гидроторакс. Полисерозит (в рамках нефротического синдрома) был установлен на основании выраженного нефротического синдрома. Пациенту была проведена патогенетическая терапия. Отмечено улучшение состояния больного, в виде снижения отеков, нормализаций артериального давления, что в свою очередь поспособствовало сохранению и улучшению качества жизни пациента. A clinical case of a patient with nephrotic syndrome, steroidresistant variant, with arterial hypertension complicated by polyserositis (hydrothorax, ascites, pleurisy) is described. The patient was admitted to the clinic in a state of moderate severity, with massive edema, polyserositis, arterial hypertension, and severe nephrotic syndrome. Diagnosis: Glomerular disease. Nephrotic syndrome, steroidresistant variant. The kidney function is reduced (GFR - 84 ml/min according to Schwartz). Bilateral exudative pleurisy. Hydrothorax. Polyserositis (within the framework of nephrotic syndrome) was established based on the severe nephrotic syndrome. The patient underwent pathogenetic therapy. An improvement in the patient's condition was noted, in the form of a decrease in edema, normalization of blood pressure, which in turn contributed to the preservation and improvement of the patient's quality of life.

scholarly journals Prosthodontic Rehabilitation of a Patient with Subtotal Maxillectomy using a Hollow Bulb Obturator

2012 ◽  
Vol 2 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Gita Rani ◽  
Amarjeet Gambhir
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Clinical Case ◽  
Soft Tissues ◽  
Prosthetic Reconstruction ◽  
Maxillary Defect ◽  
Hollow Bulb Obturator

ABSTRACT Successful prosthetic reconstruction of hemimaxillectomy defects is a challenging procedure that requires multidisciplinary expertize to achieve acceptable function, speech and esthetics. Rehabilitation of an acquired maxillary defect improves the quality of life for the patient as close to normal as possible. Obturation of the defect depends on its volume and position of remaining hard and soft tissues, to be utilized for retention, stability and support for the prosthesis. The prosthesis should be simple to handle, easy to maintain, biocompatible, light in weight and convenient for future adjustments. This case report describes a clinical case of subtotal maxillectomy, which was successfully rehabilitated with a hollow bulb obturator. How to cite this article Rani G, Gambhir A. Prosthodontic Rehabilitation of a Patient with Subtotal Maxillectomy using a Hollow Bulb Obturator. Int J Prosthodont Restor Dent 2012; 2(1):24-28.

scholarly journals Fever in children: review of national and international studies and clinical guidelines

2020 ◽  
Vol 65 (3) ◽  
pp. 153-159
Author(s):  
E. E. Lokshina ◽  
O. V. Zaytseva ◽  
S. V. Zaytseva
Keyword(s):  
Quality Of Life ◽  
Medical Care ◽  
Clinical Guidelines ◽  
Professional Communities ◽  
International Studies ◽  
Pediatric Practice ◽  
Safety And Efficacy ◽  
Adequate Therapy ◽  
Efficacy Criteria

Fever in children is one of the most common reasons for seeking medical care and use of antipyretic drugs. The reasons can be various. It is extremely important for the pediatrician to find the cause of the fever and prescribe adequate therapy. Antipyretic drugs are symptomatic, they only relieve the condition of the child and improve the quality of life. The article reviews national and international studies and clinical guidelines of professional communities on fever in children. Currently, only ibuprofen and paracetamol fully meet the safety and efficacy criteria, and they are recommended for use in pediatric practice as antipyretic drugs.

scholarly journals Study of Treatment Complications in Oncology / Hematology Patients: Protocol for a Prospective and Interventional Cohort Study from the Pasca Program

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 10-11
Author(s):  
Mauricette Michallet ◽  
Romain Buono ◽  
Mohamad Sobh ◽  
Solene Poirey ◽  
Emmanuelle Nicolas-Virelizier ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Research Funding ◽  
Patient Management ◽  
Clinical Signs ◽  
Sexual Disorders ◽  
Management Of Complications ◽  
Physical Deconditioning

Introduction In France, cancer incidence is increasing, reaching approximately 400,000 new cases in 2017. Thanks to diagnostic and therapeutic advances, net survival at 5 years is improving, with a corollary increase in the number of survivors. Among survivors, 44% have a poor quality of life due to the more or less late onset of treatment-related complications. Despite the objectives of the 2014-2019 national cancer plan considering the latest therapeutic advances, very few initiatives integrating systematic, early detection and management of complications exist in France. Methods and analysis PASCA (Care pathways through cancer) is a single-arm, interdisciplinary, prospective, interventional, cohort study. During a period of 24 months, it is intended to include 858 adults aged 18 to 65 years with non-Hodgkin and Hodgkin lymphoma, acute myeloid leukemia, testicular germ cell tumor, non-metastatic invasive breast cancer, soft tissue sarcoma, osteosarcoma or Ewing's sarcoma at Centre Leon Berard (Lyon, France). The program consists on exhaustive identification of 22 complications at 1 month, 6 months, 24 months and 60 months after the end of first line treatment: social precariousness, return-to-work issues, cognitive problems, anxiety and depression disorders, chronic fatigue, physical deconditioning, overweight/obesity, chronic pain, dermatological disorders, gastrointestinal disorders, sexual disorders, hypogonadism, premature ovarian failure, osteoporosis, chronic kidney failure, heart failure, coronary heart disease, respiratory failure, hypothyroidism, lymphedema, modifiable risk factors associated with the occurrence of secondary cancers. Each identification will give rise to management, which consists of referring the patient to a healthcare professional belonging to the network of dedicated healthcare professionals at the regional level. The course of action to be followed will be defined using decision trees based on international, national or learned society recommendations. Referral outside Centre Leon Berard will be made to a specialist doctor, a health professional from the paramedical field or the patient's general practitioner who will confirm the diagnosis and initiate patient management and follow-up. These patients will also benefit from their usual follow-up in the context of their initial malignancy. Each study visit will include a search for clinical signs using questionnaires, an assay of 12 biological parameters, a urine test strip, 5 tests evaluating physical deconditioning and an electrocardiogram. The weight, height, waist circumference, blood pressure will also be measured. Primary outcome will be the incidence of the 22 complications, measured at 1 month, 6 months, 24 months and 60 months after the end of intensive chemotherapy treatment. Ethics and dissemination The study protocol was approved by the French ethics committee (Comité de protection des personnes Ile de France IV), the study database is currently being declared and registered to the Commission Nationale de l'Informatique et des Libertés (CNIL) and the study on ClinicalTrials.gov. The results will be disseminated to patients and in peer-reviewed journals and academic conferences. Strengths and limitations of this study This study is based on a previous feasibility study with 52 patients recruited in onco-hematology, which demonstrated the feasibility of the intervention and the existence of patient management needs.(1) The study design does not include a comparator arm, as the objective of the study is to provide a comprehensive picture of treatment-related complications, especially those that appear over the long term. Due to the lack of recent data concerning some complications, sample size was calculated empirically on the basis of the active queue of patients at the Centre Leon Berard. References Michallet M, Sobh M, Buono R, Poirey S, Pascu I, Nicolas-Virelizier E, et al. Personalised Follow-up Program after Acute Phase of Treatment in Oncology/Hematology Patients Towards Early Intervention, Better Care and Quality of Life Improvement: Results from Pasca Pilot Study. Blood. 13 nov 2019;134(Supplement_1):5817-5817. Disclosures Nicolini: Sun Pharma Ltd: Consultancy; Incyte: Research Funding, Speakers Bureau; Novartis: Research Funding, Speakers Bureau.

scholarly journals Colic in infants: modern approaches to patient management

2021 ◽  
Author(s):  
С.Б. Крутихина ◽  
Е.А. Яблокова ◽  
М.А. Кудряшова ◽  
Е.В. Борисова ◽  
Е.Ю. Полотнянко
Keyword(s):  
Quality Of Life ◽  
Patient Management ◽  
Lactobacillus Reuteri ◽  
Family Stress ◽  
Prone Positioning ◽  
Functional Disorders ◽  
Infant Colic ◽  
Rome Iv ◽  
Infants And Young Children

Функциональные расстройства желудочно-кишечного тракта у младенцев и детей раннего возраста являются крайне распространенной проблемой, диагностика которых опирается на Римские критерии IV (четвертого пересмотра). Колики у младенца определенно повышают уровень стресса в семье, ухудшая качество жизни как родителей, так и ребенка. Под младенческими коликами понимаются повторяющиеся длительные периоды плача, беспокойство или раздражительность у младенцев до 5 месяцев. Патофизиология младенческих колик не полностью ясна. Для многих педиатров наблюдение за младенцами с коликами представляет проблему. Среди немедикаментозных техник можно использовать пеленание, убаюкивание с помощью шипящих звуков («ч-ш-ш-ш-ш…»), выкладывание ребенка на живот, укачивание, использование соски, а также применение газоотводной трубочки. В настоящее время активно исследуются возможности применения пробиотиков, например, Lactobacillus reuteri. Functional disorders of the gastrointestinal tract in infants and young children are an extremely common problem, the diagnosis of which is based on the Rome IV criteria. Colic in an infant definitely increases family stress levels, impairing the quality of life for both the parent and the child. Infant colic refers to repeated, prolonged periods of crying, restlessness, or irritability in infants under 5 months of age. The pathophysiology of infant colic is not entirely clear. For many pediatricians, monitoring babies with colic is a challenge. Non-drug techniques include swaddling, prone positioning, rocking, as well as a gas tube. The possibilities of using probiotics, for example, Lactobacillus reuteri, are currently being actively explored.

Understanding constipation in adults

2021 ◽  
Vol 32 (12) ◽  
pp. 480-484
Author(s):  
Margaret Perry
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
At Risk ◽  
Health Professionals ◽  
Patient Management ◽  
Frequent Reason

Constipation is a common problem which can affect any age and ethnicity and is a frequent reason for patients to seek advice from health professionals. Margaret Perry looks at the risk factors, patient management and potential complications Constipation is a common problem which can affect any age and any ethnicity and is a frequent reason for patients to seek advice from health professionals. Symptoms can vary widely from mild to severe and can impact on quality of life. Given the frequency of its occurrence, it is very likely that nurses and non-medical prescribers will be asked for advice by patients. This article will therefore look at risk factors, patient management and potential complications and hopes to provide useful information for any clinicians who may be approached for advice and guidance in dealing with this condition.

Arthrogryposis

2019 ◽  
pp. 191-196
Author(s):  
Robin D. Clark ◽  
Cynthia J. Curry
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Clinical Case ◽  
Treatment Options ◽  
Recurrence Risk ◽  
Case Presentation ◽  
Joint Mobilization ◽  
Intensive Use ◽  
Incidence Risk

This chapter reviews the incidence, risk factors, genetics, recurrence risk, and epidemiology of arthrogryposis. The most common and clinically recognizable type among the congenital contractures is amyoplasia, and treatment options are improving the quality of life for these patients. The distal arthrogryposes are mostly autosomal dominant and caused by an increasing number of genes including variants in PIEZ02 and MYH3 among several others. The lethal contracture syndromes have an expanding number of causes many of which are autosomal recessive. The majority of these conditions are recognized on US. In viable syndromes the early and intensive use of physical therapy is critical and can result in significant joint mobilization. The clinical case presentation features an infant with lethal multiple pterygia syndrome.

Parenteral Hydration in Patients with Advanced Cancer (DRAFT)

2018 ◽  
Author(s):  
Carlos Eduardo Paiva ◽  
Bianca Sakamoto Ribeiro Paiva
Keyword(s):  
Quality Of Life ◽  
Advanced Cancer ◽  
Clinical Case ◽  
Fluid Intake ◽  
Hospice Care ◽  
Important Study ◽  
The Common ◽  
To Receive

There has been much debate about the role of parenteral hydration in the last weeks and days of life. In this important study, 129 patients with advanced cancer receiving hospice care with mild to moderate dehydration who were no longer able to maintain adequate fluid intake were randomized to receive parenteral hydration of either 1 L or 100 ml of normal saline per day subcutaneously. Parenteral hydration did not significantly improve the symptoms related to dehydration, the occurrence of delirium, fatigue, quality of life, and overall survival. At the end of the chapter, a clinical case leads readers to consider the common practice of parenteral hydration.

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