scholarly journals Clinical significance of detecting organ-specificsensitization in patients with long-term chronic posttraumatic uveitis

2021 ◽  
Vol 14 (1) ◽  
pp. 15-20
Author(s):  
N. V. Balatskaya ◽  
I. A. Filatova ◽  
G. P. Zakharova ◽  
I. G. Kulikova ◽  
V. O. Denisyuk ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Clinical Significance ◽  
Histological Examination ◽  
Surgical Removal ◽  
Specific Response ◽  
Corneal Lens ◽  
Organ Specific ◽  
Tissue Antigens ◽  
Immune Inflammation ◽  
Leukocyte Migration Inhibition Test

Purpose: to assess the clinical significance of detecting organ-specific sensitization in chronic posttraumatic uveitis (CPTU) based on a comparative analysis of data from the leukocyte migration inhibition test (LMIT) and histological examination.Materials and methods. We examined 54 patients aged 17-82 with CPTU who underwent surgical removal of the eyeball (by enucleation/evisceration). To detect organ-specific sensitization, the LMIT in whole blood with extracts of corneal, lens, and uvearetinal tissue antigens was used. The eyes were subjected to histological examination after removal.Results. A positive response in LMIT was detected in 35.2 % of patients with CPTU. Pathomorphological signs of immune inflammation were found in 55.5 % of cases (30 eyes). In 23 eyes (42.6 %), the morphological picture was characterized by atrophic, fibrous and dystrophic changes in tissues. Based on the data from a comparative analysis of LMIT results and histological studies, we showed that in 16 cases out of 30 (53.3 %), morphologically confirmed immune inflammation was accompanied by sensitization to antigens of eye shells.Conclusions. In half of the cases, a productive inflammation, detected in CPTU during histological examination, was associated with the development of specific sensitization to eye tissue antigens. This result is important and should be considered when choosing how the patient should be managed, including targeted diagnostics and immunotropic therapy. The negative organ-specific response of LMIT in patients with chronic CPTU and intraocular inflammation confirmed by pathomorphological signs suggests a possible involvement of additional mechanisms of the inflammatory process, which requires further research.

Hemangiomatosis of the greater omentum – a case report

2019 ◽  
Vol 98 (4) ◽  
pp. 178-180
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Histological Examination ◽  
Case Reports ◽  
Greater Omentum ◽  
Surgical Removal ◽  
Consumption Coagulopathy ◽  
Cavernous Hemangiomas ◽  
Mesodermal Origin ◽  
Benign Tumours

Cavernous hemangiomas are benign tumours of mesodermal origin. Even though various localizations of hemangioma have been described in the literature, its occurrence in the greater omentum is very rare. Only symptomatic hemangiomas are indicated for surgical treatment. There are case reports presenting resection or surgical removal of the greater omentum with hemangioma because of mechanical syndrome, consumption coagulopathy, bleeding, infection or suspicion of a malignancy. This article presents a case report of a patient operated on for a suspicion of carcinomatosis of the greater omentum. Histological examination found hemangiomatosis in the resected greater omentum.

Pineal Apoplexy: A Case Series and Review of the Literature

2021 ◽  
Author(s):  
Martin Majovsky ◽  
David Netuka ◽  
Radim Lipina ◽  
Jan Mraček ◽  
Vladimír Beneš
Keyword(s):  
Surgical Treatment ◽  
Pineal Gland ◽  
Clinical Significance ◽  
Obstructive Hydrocephalus ◽  
Case Series ◽  
Surgical Removal ◽  
Pineal Tumor ◽  
Review Of The Literature ◽  
Melatonin Secretion ◽  
Pubmed Database

Abstract Background Pineal apoplexy is a rare condition, with unknown incidence and clinical significance. To elucidate this clinical condition, we analyzed our own case series and performed a review of the literature. Methods We enrolled all patients with a hemorrhagic pineal apoplexy who were referred to our department between January 2000 and January 2020. Hemorrhagic pineal apoplexy was defined as the presence of fluid–fluid levels inside the pineal cyst (PC) on an axial or sagittal magnetic resonance scan. In one patient, after PC apoplexy, we performed a circadian melatonin sampling from peripheral blood to determine the function of the pineal gland. The PubMed database was searched for publications using the terms “pineal” and “apoplexy.” Results Eight patients were enrolled, of which three patients underwent surgical treatment and five patients were managed conservatively. One patient was tested for circadian melatonin secretion. Results confirmed melatonin secretion with preserved physiologic circadian rhythm.Our search of the literature led us to 31 studies that comprised 30 patients with apoplectic PC, 9 with apoplectic pineal tumor, and 1 with bleeding into the normal pineal gland. Most patients presented with headache, nausea, and vomiting, less frequently with acute hydrocephalus and gaze palsy. Twenty patients with a PC underwent resection or aspiration. Two patients underwent shunt placement as the only procedure and five received both shunt and surgical removal. Six patients with a PC were observed without surgical treatment. All the nine patients with a pineal tumor were operated on. In indicated cases, four patients received radiation therapy and one received chemotherapy. Conclusion Clinical significance of hemorrhagic pineal apoplexy ranges from an asymptomatic course to rapid deterioration and death. In patients with mild symptoms, observation is indicated, whereas surgical treatment is reserved for severe cases presenting with obstructive hydrocephalus and includes cerebrospinal fluid diversion, resection of apoplectic pineal lesions, or both.

scholarly journals Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat

2003 ◽  
Vol 16 (10) ◽  
pp. 748-755 ◽  
Author(s):  
Natalie Serkova ◽  
Jost Klawitter ◽  
Claus U. Niemann
Keyword(s):  
Mitochondrial Metabolism ◽  
Specific Response ◽  
Organ Specific

Effect of Different Obturation Techniques on the Prognosis of Endodontic Therapy: A Retrospective Comparative Analysis

2016 ◽  
Vol 17 (7) ◽  
pp. 582-586 ◽  
Author(s):  
Jyoti Sachdeva ◽  
Anurag Sarin ◽  
Ajai Gupta ◽  
Shobhit Sachdeva
Keyword(s):  
Comparative Analysis ◽  
Clinical Significance ◽  
Analysis Of Variance ◽  
Root Canal ◽  
Root Canal Therapy ◽  
Quality Of Treatment ◽  
Significant Difference ◽  
Level Of Significance

ABSTRACT Introduction Success of root canal therapy (RCT) is largely dependent upon the quality of biomechanical preparation and obturation of the pulp canal. Improperly cleaned or shaped root canal, regardless of the type of obturation method and obturating material, cannot lead to the success of endodontic therapy. Hence, we conducted a clinical comparative analysis of two obturating techniques. Materials and methods A total of 140 patients receiving RCT at the department of Endodontic were included in the present study. The average follow-up time for the patients was 29 months (18–38 months). Patients were grouped into two depending on the type of obturating technique used. Evaluation of the clinical and radiographic follow-up records of the patients was done and analysis was made. One-way analysis of variance (ANOVA) was used for assessing the level of significance. Results The average age of the patients undergoing obturation with carrier-based obturation (CO) technique and lateral compaction (LC) technique was 43 and 48 years respectively. While comparing failure and success of the teeth at the time of follow-up, nonsignificant results were obtained. Significant difference was seen, while comparing the presence of voids and type of teeth in which endodontic therapy was performed using different obturating techniques. Conclusion Endodontic therapy done with LC obturating technique or with CO technique shows prognostic difference on the outcome or quality of treatment therapy. Clinical significance Quality of obturation is more important rather than type while performing endodontic therapy for better prognosis. How to cite this article Sarin A, Gupta P, Sachdeva J, Gupta A, Sachdeva S, Nagpal R. Effect of Different Obturation Techniques on the Prognosis of Endodontic Therapy: A Retrospective Comparative Analysis. J Contemp Dent Pract 2016;17(7):582-586.

scholarly journals Benign Pigmented Dermal Basal Cell Tumor in a Namibian Cheetah (Acinonyx jubatus)

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Sonja K. Heinrich ◽  
Bettina Wachter ◽  
Gudrun Wibbelt
Keyword(s):  
Histological Examination ◽  
Basal Cell ◽  
Cell Tumor ◽  
Left Shoulder ◽  
Surgical Removal ◽  
Acinonyx Jubatus ◽  
Clinical Appearance ◽  
Large Enclosure ◽  
Shoulder Blade

A 3.5-year-old wild born cheetah (Acinonyx jubatus), living in a large enclosure on a private Namibian farm, developed a large exophytic nodular neoplasm in its skin at the height of the left shoulder blade. We describe the clinical appearance, the surgical removal, and histological examination of the tumor, which was diagnosed as a moderately pigmented benign basal cell tumor. A three-year follow-up showed no evidence of recurrence after the surgery. Although neoplasia is reported in nondomestic felids, only very few concern cheetahs. So far, no case of basal cell tumor was described in this species.

scholarly journals Integrated view and comparative analysis of baseline protein expression in mouse and rat tissues

2021 ◽  
Author(s):  
Shengbo Wang ◽  
David García-Seisdedos ◽  
Ananth Prakash ◽  
Deepti Jaiswal Kundu ◽  
Andrew Collins ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Protein Expression ◽  
Rat Tissues ◽  
Protein Abundance ◽  
Proteomics Data ◽  
Pathway Enrichment ◽  
Expression Atlas ◽  
Organ Specific ◽  
High Level ◽  
Widespread Dissemination

The increasingly large amount of public proteomics data enables, among other applications, the combined analyses of datasets to create comparative protein expression maps covering different organisms and different biological conditions. Here we have reanalysed public proteomics datasets from mouse and rat tissues (14 and 9 datasets, respectively), to assess baseline protein abundance. Overall, the aggregated dataset contains 23 individual datasets, which have a total of 211 samples coming from 34 different tissues across 14 organs, comprising 9 mouse and 3 rat strains, respectively. We compared protein expression between the different organs, including the distribution of proteins across them. We also performed gene ontology and pathway enrichment analyses to identify organ-specific enriched biological processes and pathways. As a key point we carried out a comparative analysis of protein expression between mouse, rat and human tissues. We observed a high level of correlation of protein expression among orthologs between all three species in brain, kidney, heart and liver samples. Finally, it should be noted that protein expression results have been integrated into the resource Expression Atlas for widespread dissemination.

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