scholarly journals Unresolved abdominal mass

1970 ◽  
Vol 7 (1) ◽  
pp. 82-85 ◽  
Author(s):  
B Shrestha ◽  
JL Baidya
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Abdominal Mass ◽  
Human Chorionic Gonadotrophin ◽  
Cell Tumor ◽  
Complete Disappearance ◽  
Solid Mass ◽  
Undescended Testes ◽  
Provisional Diagnosis ◽  
To Come

A case of huge enhancing solid mass in the abdomen observed in 30 years old gentlemen is reported. Patient was worked up and managed conservatively outside valley with the provisional diagnosis of an appendicular lump. When examined, he was found to have huge intra abdominal mass. Interestingly when the genitalia was examined he was found to have underdeveloped empty scrotum without testes in it which he was yet not bothered. This simple examination gave us a straight clue to come up with the diagnosis of malignancy in undescended testes. Laparotomy was performed and the mass was excised. After 6 weeks postoperatively he was subjected for the chemotherapy. After 3 cycles of chemotherapy CT scan showed complete disappearance of retroperitoneal lymphadenopathy and serum tumor markers have come down to normal level. Key words: Germ cell tumor (GCT), Seminoma, Non seminomatous germ cell tumor, (NSGCT), Cryptorchidism, Alpha fetoprotein (AFP), Beta human chorionic gonadotrophin (BHCG), Lactate dehydrogenase (LDH) doi: 10.3126/kumj.v7i1.1773 Kathmandu University Medical Journal (2009), Vol. 7, No. 1, Issue 25, 82-85

The case of prenatal diagnosis of a germ cell tumor of the fetal ovary

2018 ◽  
Author(s):  
N.N. Bondarenko, E.Yu. Andreeva , N.B. Filippova
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Tumor ◽  
Ultrasound Examination ◽  
Abdominal Mass ◽  
Abdominal Cavity ◽  
Cell Tumor ◽  
Fetal Ovary ◽  
Entire Abdominal Cavity ◽  
Spontaneous Delivery

A case of prenatal ultrasound diagnosis of a rare congenital ovarian tumor is presented. By ultrasound examination at 36–37 weeks of gestation the intra-abdominal mass 66  47  74 mm occupying the entire abdominal cavity was discovered. At 38 weeks of pregnancy spontaneous delivery occurred with girl weight 2840 g. On the eighth day after birth the child has been successfully undergone surgery. Histological examination revealed congenital germ-cell tumor with structures of dysgerminoma and yolk sac tumor.

scholarly journals Malignant Mixed Germ Cell Ovarian Tumor in Pregnant Female

2013 ◽  
Vol 2 (2) ◽  
pp. 233
Author(s):  
S. Kaur ◽  
V. K. Bodal ◽  
M. S. Bal ◽  
R. Bhagat ◽  
N. Gupta
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Neoplasms ◽  
Abdominal Mass ◽  
Primordial Germ Cells ◽  
Cell Tumor ◽  
Pregnant Female ◽  
Germ Cell Tumours ◽  
Mixed Germ Cell Tumor ◽  
Initial Surgery

Ovarian germ cell tumours comprise approximately 15% to 20% of all ovarian neoplasms. In pregnant females, its incidence is very low. They arise from primordial germ cells derived from the embryonal gonad. Malignant germ cell tumours comprise less than 5% of all ovarian neoplasms. Most malignant ovarian neoplasms in pregnant women are at early stages and are associated with good prognosis both for the mother and for the neonate. Histologic subtypes and prognosis do not differ from tumors not associated with pregnancy. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients. We present a case of malignant mixed germ cell tumor in a pregnant female who presented with abdominal mass after delivering a normal child. Histological and biochemical tumour markers confirmed it to be malignant mixed germ cell tumor.

scholarly journals Rapidly enlarging abdominal mass in a patient with recurrent germ cell tumor

2019 ◽  
Vol 7 (11) ◽  
pp. 2285-2286
Author(s):  
Lauren Ho ◽  
Louis Pisters ◽  
Shi‐Ming Tu
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Abdominal Mass ◽  
Cell Tumor

scholarly journals A Case Report on Malignant Ovarian Germ Cell Tumor

2021 ◽  
pp. 43-47
Author(s):  
Sanket V. Madavi ◽  
Samruddhi Gujar ◽  
Ranjana Sharma ◽  
Ruchira Ankar ◽  
Savita Pohekar ◽  
...  
Keyword(s):  
Weight Loss ◽  
Case Report ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Therapeutic Intervention ◽  
Abdominal Mass ◽  
Germ Cell Tumors ◽  
Clinical Findings ◽  
Cell Tumor ◽  
Intervention Patient

Introduction: A germ cell is a type of Tumor that arises from germ cell (GCT). Germ cell tumors are both cancerous and benign. The gonads contains majority of germ cell (ovary and testis). GCT that arise outside the gonads could be the result of embryo devlopment errors. Clinical Findings: Abdominal mass without pain, backache, and weight loss. Diagnostic Evaluation: HCG and alphafetoprotein level in the blood identifying women with malignant ovarian germ cell tumor is beneficial. Serum alphafetoprotein and HCG is elevated as condition progress. Therapeutic Intervention: Patient treated with inj. Bleomycin, inj. Cisplatin, inj.Etoposide, tab Pan 40 miligram and inj. Emset. Conclusion: A 3year old female was admitted in AVBRH Sawangi Meghe wardha with the major complaint of right abdominal swelling for 6 month, both when they observed abdominal mass without pain and swelling was small in size and backache and weight loss.

scholarly journals Clinical Characteristics of Pediatric with Germ Cell Tumor: Experience in a Developing Country

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Lelani Reniarti ◽  
Anisah Febri ◽  
Nur Melani Sari
Keyword(s):  
Nutritional Status ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Clinical Characteristics ◽  
Abdominal Mass ◽  
Clinical Manifestations ◽  
Cell Tumor ◽  
Cross Sectional ◽  
Common Location ◽  
End Of Treatment

Background: Germ cell tumor (GCT) occurs in 3% of pregnancy malignancies and increases by 15% during adolescence. In developing countries, the five-year survival rate is 98% and 80% for GCT earlier stage and malignant tumor, respectively. This study aimed to gather information about clinical manifestations of GCT and to evaluate the treatment outcome in pediatric GCT patients at Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaMethods: A descriptive cross-sectional study design with a total sampling method was conducted using secondary data from the medical record of pediatric patients diagnosed with GCT from 2015 to 2018. Data on nutritional status, clinical characteristics, histopathology stage, hematological profiles, chemical markers, treatment methods, completeness of treatment, and outcome at the end of treatment were collected and presented using tables and charts.Results: Of the 44 subjects, girls (77.3%) were predominant, with a mean age of 2 years old and normal nutritional status (59.1%). Patients generally had abdominal mass (97.7%) and most had intragonadal GCT (95.5%), with ovarium (76.2%) as the most common location. The most frequent GCT histopathology was yolk sac tumor (34.1%), with an Alpha-fetoprotein (AFP) level of >100.000 (6.8%). Almost all patients (97.7%) had undergone surgery; however, 47% of patients did not complete their treatment. At the end of treatment, the majority of patients survived (86.4%).Conclusion: Germ cell tumor has various clinical characteristics. Understanding these characteristics will enable clinicians to make a proper diagnosis and provide immediate management that will lead to a better prognosis.

Cluster Analysis of p53 and Ki67 Expression, Apoptosis, Alpha-Fetoprotein, and Human Chorionic Gonadotrophin Indicates a Favorable Prognostic Subgroup Within the Embryonal Carcinoma Germ Cell Tumor

2003 ◽  
Vol 21 (14) ◽  
pp. 2679-2688 ◽  
Author(s):  
Madhu Mazumdar ◽  
Jennifer Bacik ◽  
Satish K. Tickoo ◽  
Deborah Dobrzynski ◽  
Alessia Donadio ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Tumor Biology ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Cell Tumor ◽  
Alpha Fetoprotein ◽  
Risk Status

Purpose: The prognostic information provided by alpha-fetoprotein and human chorionic gonadotrophin in the management of germ cell tumor (GCT) patients is a biochemical reflection of tumor differentiation. Ki67, p53, and apoptosis have been found to be related to proliferation (Ki67), cell death (p53, apoptosis), and possibly differentiation chemoresistance (p53). We sought to determine whether simultaneous expression of one or more of these markers could identify clinically relevant subgroups of patients with nonseminomatous GCT (NSGCT). Patients and Methods: These five marker values were obtained for 95 previously untreated patients with embryonal carcinoma with or without other germ cell components. A multivariate cluster analysis was performed to identify patients with similar marker patterns. Results: One prominent cluster (n = 37; 36 testis retroperitoneum), consisting of 26 (70%) good-risk (GR), nine (24%) intermediate-risk (IR), and two (6%) poor-risk (PR) patients, as defined by the International Germ Cell Consensus Cancer Group (IGCCCG), was observed. The 5-year survival of the prominent cluster (with 30% IR/PR patients) was 94% (95% confidence interval [CI], 86% to 100%), which is comparable to the 91% (95% CI, 89% to 93%) 5-year survival of the IGCCCG GR patients. IGCCCG risk status (P = .005) and cluster affiliation (P = .04) were independent predictors of outcome with hazard ratios of 5.0 (95% CI, 1.6 to 15.4) and 4.6 (95% CI, 1.04 to 20.1), respectively. Conclusion: These results suggest that there is a subgroup of NSGCT patients with embryonal carcinoma (with or without other histologies) with a specific tumor biology profile (high Ki67, low apoptosis, and low p53) whose survival is better than that of the overall patient group. The unexpectedly good outcome for the prominent cluster and independent-risk status suggest that subgroups of GCT reflecting different abilities to respond to treatment exist within IGCCCG prognostic categories.

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