scholarly journals Distinct improvement of pulmonary function, ground-glass opacity, hypoxia and physical findings in an idiopathic pulmonary fibrosis patient after pirfenidone treatment : a case report with a review of the literature

2020 ◽  
Vol 67 (3.4) ◽  
pp. 358-361
Author(s):  
Takeshi Imakura ◽  
Yuko Toyoda ◽  
Seidai Sato ◽  
Kazuya Koyama ◽  
Haruka Nishimura ◽  
...  
Keyword(s):  
Case Report ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Function ◽  
Ground Glass Opacity ◽  
Idiopathic Pulmonary Fibrosis Patient ◽  
Ground Glass ◽  
Review Of The Literature ◽  
Physical Findings

scholarly journals Serial CT analysis in idiopathic pulmonary fibrosis: comparison of visual features that determine patient outcome

Thorax ◽  
2020 ◽  
Vol 75 (8) ◽  
pp. 648-654 ◽  
Author(s):  
Joseph Jacob ◽  
Leon Aksman ◽  
Nesrin Mogulkoc ◽  
Alex J Procter ◽  
Bahareh Gholipour ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Clinical Importance ◽  
Ground Glass Opacity ◽  
Mortality Prediction ◽  
Ground Glass ◽  
Traction Bronchiectasis

AimsPatients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotic medication and patients with non-IPF fibrosing lung disease often demonstrate rates of annualised forced vital capacity (FVC) decline within the range of measurement variation (5.0%–9.9%). We examined whether change in visual CT variables could help confirm whether marginal FVC declines represented genuine clinical deterioration rather than measurement noise.MethodsIn two IPF cohorts (cohort 1: n=103, cohort 2: n=108), separate pairs of radiologists scored paired volumetric CTs (acquired between 6 and 24 months from baseline). Change in interstitial lung disease, honeycombing, reticulation, ground-glass opacity extents and traction bronchiectasis severity was evaluated using a 5-point scale, with mortality prediction analysed using univariable and multivariable Cox regression analyses. Both IPF populations were then combined to determine whether change in CT variables could predict mortality in patients with marginal FVC declines.ResultsOn univariate analysis, change in all CT variables except ground-glass opacity predicted mortality in both cohorts. On multivariate analysis adjusted for patient age, gender, antifibrotic use and baseline disease severity (diffusing capacity for carbon monoxide), change in traction bronchiectasis severity predicted mortality independent of FVC decline. Change in traction bronchiectasis severity demonstrated good interobserver agreement among both scorer pairs. Across all study patients with marginal FVC declines, change in traction bronchiectasis severity independently predicted mortality and identified more patients with deterioration than change in honeycombing extent.ConclusionsChange in traction bronchiectasis severity is a measure of disease progression that could be used to help resolve the clinical importance of marginal FVC declines.

scholarly journals Ground-glass opacity as a paradoxical reaction in miliary tuberculosis: A case report and review of the literature

IDCases ◽  
2020 ◽  
Vol 19 ◽  
pp. e00685 ◽  
Author(s):  
Yuki Tokuyama ◽  
Takeshi Matsumoto ◽  
Yusuke Kusakabe ◽  
Naoki Yamamoto ◽  
Kensaku Aihara ◽  
...  
Keyword(s):  
Case Report ◽  
Miliary Tuberculosis ◽  
Ground Glass Opacity ◽  
Ground Glass ◽  
Review Of The Literature ◽  
Paradoxical Reaction

scholarly journals Genomic analysis between idiopathic pulmonary fibrosis and associated lung cancer using laser‐assisted microdissection: A case report

2021 ◽  
Author(s):  
Yuko Iida ◽  
Yasuhiro Gon ◽  
Yoko Nakanishi ◽  
Yusuke Kurosawa ◽  
Yoshiko Nakagawa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Genomic Analysis

Pulmonary Function Tests and Idiopathic Pulmonary Fibrosis

CHEST Journal ◽  
1997 ◽  
Vol 111 (1) ◽  
pp. 7-8 ◽  
Author(s):  
Steven H. Kirtland ◽  
Richard H. Winterbauer
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Function Tests

Quantitative CT analysis of honeycombing area in idiopathic pulmonary fibrosis: Correlations with pulmonary function tests

2016 ◽  
Vol 85 (1) ◽  
pp. 125-130 ◽  
Author(s):  
Hiroaki Nakagawa ◽  
Yukihiro Nagatani ◽  
Masashi Takahashi ◽  
Emiko Ogawa ◽  
Nguyen Van Tho ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Quantitative Ct ◽  
Function Tests ◽  
Ct Analysis ◽  
Quantitative Ct Analysis

scholarly journals Occurrence of idiopathic pulmonary fibrosis during immunosuppressive treatment: a case report

2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Stefania Cerri ◽  
Giacomo Sgalla ◽  
Luca Richeldi ◽  
Fabrizio Luppi
Keyword(s):  
Case Report ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Immunosuppressive Treatment

scholarly journals Gejala Klinis dan Pemeriksaan Penunjang pada Neonatus Terinfeksi COVID-19

e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Jason Rampengan ◽  
Johnny Rompis ◽  
Valentine Umboh
Keyword(s):  
Cohort Study ◽  
Case Report ◽  
Literature Review ◽  
Observational Study ◽  
Ct Scan ◽  
Clinical Symptoms ◽  
Ground Glass Opacity ◽  
Google Scholar ◽  
Ground Glass ◽  
Laboratory Examinations

Abstract: COVID-19 is spreading at an extremely rapid rate and can affect all age groups, albeit, information about clinical symptoms and laboratory examinations of COVID-19 I in neonates is still quite limited. This study was aimed to determine the clinical symptoms, radiographic examinations especially CT-scans, and laboratory tests that could appear in neonates suffering from COVID-19. This was a literature review study using three databases, namely Pubmed, Clinical Key, and Google Scholar. The keywords used were Covid-19 / SARS-CoV-2 AND Neonatus AND sign and symptoms AND laboratory. The selection based on inclusion and exclusion criteria, obtained 15 case report studies, three retrospective studies, one observational study, and one cohort study. The review revealed that the most frequent clinical features that appeared were fever (54.8%), dyspnoea (35.4%), and cough (29%). Meanwhile, for CT-Scan radiographs, there were 14 of 31 neonates (45.2%) did not show any abnormalities or normal. The most frequent abnormal image was ground glass opacity (GGO) (29%). Among laboratory examinations, lymphopenia was the most common abnormality (32.2%). Moreover, leukocytosis, leukopenia, thrombocytopenia, increased PCT, AST, etc. could also occur. Of all the reviewed literatures, there were no death cases of neonates died due to COVID-19. In conclusion, fever, dyspnea, cough, and lymphopenia are the most common findings as well as GGO in the CT-Scan radiograph.Keywords: COVID-19, neonates Abstrak: COVID-19 menyebar dengan sangat pesat dan dapat menjangkiti semua kelompok usia namun informasi mengenai gejala klinis dan pemeriksaan laboratorium terhadap kelompok neonatus masih terbatas. Penelitian ini bertujuan untuk mengetahui gambaran klinis, pemeriksaan radiografi khususnya CT-Scan, dan pemeriksaan laboratorium yang bisa muncul pada neonatus dengan COVID-19. Jenis penelitian ialah literature review dengan pencarian data menggunakan tiga database yaitu Pubmed, Clinical Key, dan Google Scholar. Kata kunci yang digunakan yaitu Covid-19/ SARS-CoV-2 AND Neonatus AND sign and symptom AND laboratory. Hasil seleksi berdasarkan kriteria inklusi dan ekslusi mendapatkan 15 penelitian case report, tiga retrospective study, satu observational study, dan satu cohort study. Hasil kajian menunjukkan bahwa gambaran klinis yang paling sering muncul ialah demam (54,8%), sesak (35,4%), dan batuk (29%). Pemeriksaan radiografi CT-Scan, neonatus yang tidak menunjukkan kelainan (normal) terdapat pada 14 dari 31 neonatus diamati (45,2%), sedangkan kelainan yang sering muncul ialah ground glass opacity/GGO (29%). Pada pemeriksaan laboratorium, limfopenia merupakan kelainan tersering (32,2%), sedangkan leukositosis, leukopenia, trombositopenia, peningkatan PCT, AST, dll juga bisa terjadi. Dari semua literatur yang dikaji, tidak ditemukan kasus kematian neonatus akibat COVID-19. Simpulan penelitian ini ialah gambaran klinis yang paling sering muncul pada neonatus ialah demam, sesak, dan batuk, limfopenia, dan GGO pada CT-Scan.Kata kunci: COVID-19, neonatus

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