Retinol, α-Tocopherol and Vitamin D3 in White MuscleDisease

2018 ◽  
Vol 74 (1) ◽  
pp. 6029-2018
Author(s):  
HANDAN MERT ◽  
SERKAN YİLDİRİM ◽  
IBRAHİM HAKKİ YORUK ◽  
KİVANC IRAK ◽  
BAHAT COMBA ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin D3 ◽  
White Muscle ◽  
Bone Structure ◽  
Early Stage ◽  
Vitamin A Deficiency ◽  
Muscle Disease ◽  
Control Group ◽  
White Muscle Disease ◽  
Fat Soluble Vitamins

Vitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fat-soluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – and the growth, reproduction and differentiation of epithelial cells. Vitamin A deficiency leads to the keratinization of the epithelium, and disorders related to the metaplasies of the genital and genitourinary systems. Conversely, vitamin D is defined as a pro-hormone and is responsible for Cahomeostasis, and thus indirectly affects the bone metabolism, bone structure, and cellular and neural functions of Ca. White muscle disease (WMD) can occur in newborn lambs, but is more commonly seen in lambs of up to 3 months of age. In this study, 30 lambs of 3 to 50-days-old from different flocks diagnosed with White Muscle Disease (WMD) were selected as research material, while the control group consisted of 8 healthy lambs. With the aim of clarifying the cause of WMD, serum fat-soluble vitamins, retinol, α-tocopherol and vitamin D3 levels were determined in 16 lambs. Gluteal and heart musclet issue samples also were taken from 30 lambs with WMD. The vitamin levels of the samples were analysed by HPLC. The levels of serum α-tocopherol, retinols, and vitamin D3 were foundto be low in the diseased animals, but only retinol (p<0.001) and α-tocopherol (p<0.0011) level differences were statistically relevant. Macroscopically, Zenker’s necrosis was determined in the heart muscles of 17 lambs, and in the gluteal and chest muscles of 6 lambs. 7 lambs displayed necrosis in both their heart and in gluteal muscles. The samples were analyzed microscopically to reach similar findings: swollen homogeneous pink muscles, pycnotic nuclei, and hyperaemic and haemorrhagic blood vessels in gluteal, chest and heart muscles. Hyaline degeneration and Zenker's necrosis, dystrophic regions in necrotic areas, cc was detected as a severe disease in lambs at an early stage of life with advanced degeneration in different muscle tissues. Deficiency of fat-soluble vitamins was also detected in the sick animals. Control group lambs had higher levels of α tocopherol and retinol (p<0.001) compared to the sick lambs. .

scholarly journals Retinol, α-tocopherol and vitamin D3 in White MuscleDisease

2018 ◽  
Vol 74 (1) ◽  
pp. 6027-2018
Author(s):  
HANDAN MERT ◽  
SERKAN YİLDİRİM ◽  
IBRAHİM HAKKİ YORUK ◽  
KİVANC IRAK ◽  
BAHAT COMBA ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin D3 ◽  
White Muscle ◽  
Bone Structure ◽  
Early Stage ◽  
Vitamin A Deficiency ◽  
Muscle Disease ◽  
Control Group ◽  
White Muscle Disease ◽  
Fat Soluble Vitamins

Vitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fat-soluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – and the growth, reproduction and differentiation of epithelial cells. Vitamin A deficiency leads to the keratinization of the epithelium, and disorders related to the metaplasies of the genital and genitourinary systems. Conversely, vitamin D is defined as a pro-hormone and is responsible for Cahomeostasis, and thus indirectly affects the bone metabolism, bone structure, and cellular and neural functions of Ca. White muscle disease (WMD) can occur in newborn lambs, but is more commonly seen in lambs of up to 3 months of age. In this study, 30 lambs of 3 to 50-days-old from different flocks diagnosed with White Muscle Disease (WMD) were selected as research material, while the control group consisted of 8 healthy lambs. With the aim of clarifying the cause of WMD, serum fat-soluble vitamins, retinol, α-tocopherol and vitamin D3 levels were determined in 16 lambs. Gluteal and heart musclet issue samples also were taken from 30 lambs with WMD. The vitamin levels of the samples were analysed by HPLC. The levels of serum α-tocopherol, retinols, and vitamin D3 were foundto be low in the diseased animals, but only retinol (p<0.001) and α-tocopherol (p<0.0011) level differences were statistically relevant. Macroscopically, Zenker’s necrosis was determined in the heart muscles of 17 lambs, and in the gluteal and chest muscles of 6 lambs. 7 lambs displayed necrosis in both their heart and in gluteal muscles. The samples were analyzed microscopically to reach similar findings: swollen homogeneous pink muscles, pycnotic nuclei, and hyperaemic and haemorrhagic blood vessels in gluteal, chest and heart muscles. Hyaline degeneration and Zenker's necrosis, dystrophic regions in necrotic areas, cc was detected as a severe disease in lambs at an early stage of life with advanced degeneration in different muscle tissues. Deficiency of fat-soluble vitamins was also detected in the sick animals. Control group lambs had higher levels of α tocopherol and retinol (p<0.001) compared to the sick lambs. .

Whole wheat grain feeding of Merino ewes. 2. Influence of wheat and vitamin A on reproductive performance

1976 ◽  
Vol 16 (78) ◽  
pp. 38
Author(s):  
WR McManus ◽  
JA Reynolds ◽  
EM Roberts
Keyword(s):  
Vitamin A ◽  
Reproductive Performance ◽  
White Muscle ◽  
Muscle Disease ◽  
Wheat Grain ◽  
Control Groups ◽  
White Muscle Disease ◽  
Linear Effect ◽  
Whole Wheat ◽  
Lamb Survival

In two experiments Merino breeding ewes were fed wheat in pens (wheat/pen) or small paddocks (wheat/paddock) from joining to weaning. Three levels of wheat were examined in each experiment (L1, M1, H1-experiment 1 ; L2, M2, H2-experiment 2) and at each wheat level a group of ewes received vitamin A. Control groups of ewes were run at pasture. The percentage of ewes pregnant in experiment 1 was higher in groups fed pasture than in groups fed wheat. There were no differences due to wheat level or vitamin A treatments. In experiment 2 there was an interaction between treatments in their effects on pregnancy rate. In experiment 2 wheat level had a linear effect on the proportion of multiple births and wheat/pen ewes gave birth to fewer twins than wheat/paddock ewes. The effects of wheat level on lamb birth weight were linear and quadratic in experiments 1 and 2 respectively. Lamb survival between birth and weaning was not influenced by wheat level or vitamin A in experiment 1. Lamb survival among groups fed wheat and pasture was 46 per cent and 84 per cent respectively. In experiment 2 there was an interaction between the treatments in lamb survival. In experiments 1 and 2, 66 per cent and 53 per cent respectively of lamb deaths among groups fed wheat were attributed to starvation. Goitre was diagnosed in 9 per cent of dead lambs from the wheat/pen groups of experiment 2. In both experiments white muscle disease was found in dead lambs from the wheat/pen groups.

scholarly journals Effect of selenium-vitamin E injection in selenium-deficient dairy goats and kids on the Mexican plateau

2005 ◽  
Vol 57 (1) ◽  
pp. 77-84 ◽  
Author(s):  
J.E. Ramírez-Bribiesca ◽  
J.L. Tórtora ◽  
M. Huerta ◽  
L.M. Hernández ◽  
R. López ◽  
...  
Keyword(s):  
Vitamin E ◽  
White Muscle ◽  
Muscle Disease ◽  
Control Group ◽  
Dairy Goats ◽  
Control Groups ◽  
Mating Period ◽  
White Muscle Disease ◽  
A Value ◽  
And Control

Three experiments were carried out to determine the optimum selenium-vitamin E injection level to maintain acceptable blood selenium (Se) status of does and kids, as well as to determine the relation of that status to mortality rates in kids. In experiment 1, 238 goats were assigned to one of three groups during the mating period: A1-control, A2- 0.06mgSe+0.8IU vitE/kgBW and A3-0.125mgSe+1.7IU vitE/kgBW. No differences (P>.05) for fertility and prolificacy were observed among the groups. Blood Se concentration did not differ among Se-vit E groups and control group before injection, and both groups showed Se deficient condition. There was a trend (P<.05, 32%) to increase Se blood level 60 days post-treatment, but difference was not observed between A2 and control groups, while difference (P<.05; 103%) was observed between A1 and A2 groups vs high Se injection (A3 group). In experiment 2, 48 goats were divided into four groups: B1- control, B2- 0.125mgSe+1.7IU vitE/kgBW, B3- 0.25mgSe+3.4IU vitE/kgBW and B4- 0.31mgSe+4.2IU vitE/kgBW. The B4 group reached the highest concentration at the third month after injection (0.11 ppm), then started to decline after 100 days, reaching a value slightly higher than B2 and B3 on the 135th day of pregnancy. Results of B2 and B3 groups were slightly higher that those of B1 (P<0.05). In experiment 3, 194 kids (3 to 7 days postpartum) born from Se-deficient goats were used to compare the effectiveness of Se injection. They were divided into three groups: C1- control, C2- 0.3mgSe+4.2IU vit E/kg BW and C3- 0.6mgSe+8.4IU vit E/kg BW. C1 showed the highest percentage of mortality (60%) as compared to treated Se groups, that scored equal percentage of deaths (22% averaged). The concentration of Se in blood, on day 20th after the onset of the treatment rapidly increased, according with level of Se injection. The 0.3mgSe/kgBW Se injection increased the blood Se concentration in pregnant goats and it was effective to prevent white muscle disease lesions, besides enhancing the survival of kids until weaning.

Effects of Selenium and Vitamin E on White Muscle Disease

Science ◽  
1958 ◽  
Vol 128 (3331) ◽  
pp. 1090-1090 ◽  
Author(s):  
O. H. MUTH ◽  
J. E. OLDFIELD ◽  
L. F. REMMERT ◽  
J. R. SCHUBERT
Keyword(s):  
Vitamin E ◽  
White Muscle ◽  
Muscle Disease ◽  
White Muscle Disease

Vitamin A deficiency regulates the expression of ferritin in young male Wistar rats

2021 ◽  
Vol 34 ◽  
Author(s):  
Mauricio RESTREPO-GALLEGO ◽  
Luis Eduardo DÍAZ ◽  
Juan David OSPINA-VILLA ◽  
Danny CHINCHILLA-CÁRDENAS
Keyword(s):  
Iron Deficiency ◽  
Vitamin A ◽  
Biochemical Parameters ◽  
Serum Iron ◽  
Wistar Rats ◽  
Vitamin A Deficiency ◽  
Young Male ◽  
Control Group ◽  
Transferrin Receptors ◽  
Male Wistar Rats

ABSTRACT Objective Iron deficiency and vitamin A deficiency are two of the main micronutrient deficiencies. Both micronutrients are essential for human life and children's development. This study aimed to investigate the effects of vitamin A deficiency on ferritin and transferrin receptors' expression and its relationship with iron deficiency. Methods Five diets with different vitamin A-to-iron ratios were given to thirty five 21-day-old male Wistar rats (separated in groups of seven animals each). The animals received the diet for six weeks before being euthanized. Serum iron and retinol levels were measured as biochemical parameters. Their duodenums, spleens, and livers were analyzed for the expression of ferritin and transferrin receptors by Western Blotting. Results Regarding biochemical parameters, the results show that when both vitamin A and iron are insufficient, the serum iron content (74.74µg/dL) is significantly lower than the control group (255.86µg/dL). The results also show that vitamin A deficiency does not influence the expression of the transferrin receptor, but only of the ferritin one. Conclusion Vitamin A deficiency regulates the expression of ferritin in young male Wistar rats.

Analysis of Fat-Soluble Vitamins. XX. Determination of Vitamin D in Multivitamin Preparations. Second Collaborative Study

1978 ◽  
Vol 61 (3) ◽  
pp. 735-745
Author(s):  
Ellen J De Vries ◽  
Frits J Mulder ◽  
Ben Borsje
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Test Data ◽  
Vitamin D3 ◽  
Collaborative Study ◽  
Three Samples ◽  
The Mean ◽  
Fat Soluble Vitamins

Abstract The official first action method for determining vitamin D in multivitamin preparations was modified. The method was collaboratively studied by 7 laboratories, using 6 preparations in oil. The preparations consisted of vitamin D at various levels and at various ratios (in w/w) to vitamin A. Three samples contained cholecalciferol and 3 samples contained vitamin D3 from vitamin D3 resin. After outliers were eliminated by the Dixon test, data were analyzed and averages were compared with amounts of vitamin D known to be in each sample. For samples with vitamin D: vitamin A ratios of 1:0.5, 1:5, and 1:10, the mean vitamin D recoveries were 98.8, 94.6, and 90.7%, respectively. The method has been adopted as official final action.

The development of a soluble glass bolus to deliver selenium and cobalt to sheep

1996 ◽  
Vol 1996 ◽  
pp. 245-245
Author(s):  
N.R. Kendall ◽  
A.M. Mackenzie ◽  
S.B. Telfer
Keyword(s):  
Trace Element ◽  
White Muscle ◽  
Selenium Deficiency ◽  
Muscle Disease ◽  
Single Element ◽  
White Muscle Disease ◽  
Soluble Glass ◽  
Copper Supplementation ◽  
Ruminant Animals ◽  
The Uk

Trace element deficiencies have been reported throughout the UK and are known to decrease the productivity and welfare of animals. Selenium deficiency is characterised by muscular myopathy, white muscle disease or stiff lamb disease. Subclinical deficiencies can also cause reduced growth rate and impaired immune function. In ruminant animals, cobalt is required for the synthesis of vitamin B12 and deficiency leads to Pine, characterised by emaciation, anaemia and listlessness. Trace element deficiencies can be due to either a single element or multiple elements. Situations occur particularly in sheep where cobalt and/or selenium are deficient but where copper supplementation can be toxic. To correct these deficiencies, a single long-lasting and effective treatment in the form of a soluble glass bolus has been designed to release cobalt and selenium. This new bolus is similar to the commercial Cosecure® bolus, which is a Co/Se/Cu soluble glass, in which zinc replaces the copper.

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