scholarly journals Ameliorative effect of vitamin E against radiofrequency radiation emitted from mobile phone-induced hematological and histopathological alterations in male albino mice

2020 ◽  
Vol 0 (0) ◽  
pp. 1-8
Author(s):  
Mona Ibraheim ◽  
Aziza amin
2020 ◽  
Vol 4 (1) ◽  
pp. 017-028
Author(s):  
Gamal Elsayed Abouelghar ◽  
Rania Ibrahim Yassien ◽  
Zeinab Abd-Elghany El-Bermawy ◽  
Hager Ali Ammar ◽  
Yassmin Abd-Elaziz Shalaby

The Neonicotinoid insecticides are presently used in great amounts, but this can be a problem when the possible risks of occupational and environmental contamination are considered. The objective of this study was to investigate the potential adverse effects of sublethal doses of Thiamethoxam insecticide on serum biochemical, oxidative stress and histological alterations in male albino mice via 28-day repeated-dose oral toxicity study. The possible ameliorative effect of selenium plus vitamin E against the harmful effects of Thiamethoxam was also investigated. Mice in Thiamethoxam-treated groups received three sublethal doses (6, 12, and 30 mg/kg b.w./day). Animals in another group were orally co-administered selenium + vitamin E with the higher dose of insecticide. The results showed that Thiamethoxam significantly (p < 0.05) increased cholesterol levels and liver enzyme activities, in dose-dependent manner, compared to those of the control group. Levels of creatinine were not significantly changed, whereas uric acid increased at high doses. The oxidative stress parameters were significantly increased in association with decrease in total antioxidants level. The histological analysis revealed that the higher dose induced various alterations in tissues of vital organs, i.e. liver, kidney, lung and testes. Interestingly, the ameliorative effect of selenium + vitamin E in restoring the oxidative stress parameters was reflected by reducing severity of histopathological lesions. In conclusion, it appears that the sublethal dose < 6.0 mg/kg b.w./day, in repeated dose 28-day oral toxicity study, in male albino mice may be considered as No-Observed-Adverse-Effect-Level (NOAEL) of Thiamethoxam. Additionally, the antioxidant selenium, in mixture with vitamin E, showed an ameliorative effect against Thiamethoxam-induced toxicity.


2013 ◽  
Vol 33 (3) ◽  
pp. 216-222 ◽  
Author(s):  
Muzaffer Tas ◽  
Suleyman Dasdag ◽  
Mehmet Zulkuf Akdag ◽  
Umut Cirit ◽  
Korkut Yegin ◽  
...  

2016 ◽  
Vol 5 (1) ◽  
pp. 101
Author(s):  
Milad Baradaran-Ghahfarokhi ◽  
SeyyedMohammad Javad Mortazavi ◽  
HamidReza Baradaran-Ghahfarokhi ◽  
MohammadReza Abdi ◽  
NayyerSadat Mostafavi ◽  
...  

2013 ◽  
Vol 33 (9) ◽  
pp. 911-927 ◽  
Author(s):  
SA Mansour ◽  
DA Mohamed ◽  
L Gamet-Payrastre

During gestation and lactation, the experimental mice dams received one of the following treatments: (a) diet free of pesticide; (b) diet enriched with endosulfan (END); 30.0 µg kg−1; (c) diet free of pesticide + oral vitamin E (α-tocopherol; 200 mg kg−1 per mouse); and (d) diet enriched with END (30.0 µg kg−1) + oral vitamin E (200 mg kg−1 per mouse). At weaning, pups and dams were killed, and selected organs as well as blood samples were collected for analyses. Compared with the control results, END induced alteration in a number of biochemical and histopathological parameters either in the dams or their offspring. The ameliorative effect of vitamin E to superoxide dismutase based on the “ameliorative index (AI)” for mothers and pups was 0.84 and 0.72, respectively. The AI for malondialdehyde reached a maximum value of nearly equal to 1.0 for dams or pups. For butyryl cholinesterase, the AI was 0.90 and 0.94 for dams and pups, respectively. In conclusion, a dietary exposure during gestation and lactation to low dose of END caused significant changes in the mother but also in the weaned animals that had not been directly exposed to this pesticide. These biological and histological alterations could be reversed to a great extent by oral supplementation of vitamin E.


Author(s):  
Angelo Levis ◽  
Laura Masiero ◽  
Paolo Orio ◽  
Susan Biggin ◽  
Spiridione Garbisa

Uncertainty about the association between health risks and exposure to radiofrequency radiation emitted by cellular and cordless mobile phones can be addressed by a critical analysis of the methodology used in studies assessing this relationship. Studies funded by cellphone companies give reassuring conclusions but are affected by biases and flaws, whereas public-funded studies are without these errors and show acute and chronic effects, including head tumors, findings supported by biological evidence.


2020 ◽  
Vol 34 (3) ◽  
Author(s):  
Reham Z. Hamza ◽  
Samy M. EL‐Megharbel ◽  
Tariq Altalhi ◽  
Adil A. Gobouri ◽  
Ashjan Ayad Alrogi

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