Carisoprodol-Induced Histological and Immunohistochemical Changes in Spleen of Pregnant Rats

There have been many reports which establish a relationship between the pineal and sexual structures, including gonadal hypertrophy after pinealectomy, and gonadal atrophy after injection of pineal homogenates or of melatonin. In order to further delineate this relationship the pineals from 5 groups of female rats were studied by electron microscopy:ControlsPregnant ratsAfter 4 weekly injections of 0.1 mg. estradiol benzoate.After 8 daily injections of 150 mcgm. melatonin (pineal hormone).After 8 daily injections of 3 mg. serotonin (melatonin precursor).No ultrastructural differences were evident between the control, and the pregnancy and melatonin groups. However, the estradiol injected animals exhibited a marked increase in the amount and size of rough endoplasmic reticulum within the pineal cells.

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Effect of Matricaria chamomilla L. extract on fetal absorption, placenta structure and liver of diabetic pregnant rats.

Planta Medica ◽

10.1055/s-0031-1282942 ◽

2011 ◽

Vol 77 (12) ◽

Author(s):

F Namjooyan ◽

M Panahi ◽

F Ahmadpour ◽

A Darvish ◽

M Azemi ◽

...

Keyword(s):

Matricaria Chamomilla ◽

Pregnant Rats

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ADMINISTRATION OF CRYSTALLINE GROWTH HORMONE TO PREGNANT RATS

Acta Endocrinologica ◽

10.1530/acta.0.0140181 ◽

1953 ◽

Vol 14 (2) ◽

pp. 181-188 ◽

Cited By ~ 8

Author(s):

Bengt Engfeldt ◽

Gösta T. Hultquist

Keyword(s):

Growth Hormone ◽

Pregnant Rats ◽

Crystalline Growth

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ZUM WIRKUNGSMECHANISMUS VON AN FETEN ANTIMASKULIN WIRKSAMEN GESTAGENEN

Acta Endocrinologica ◽

10.1530/acta.0.045s139 ◽

1964 ◽

Vol 45 (4_Suppl) ◽

pp. S139-S153 ◽

Cited By ~ 43

Author(s):

K. Junkmann ◽

F. Neumann

Keyword(s):

Pituitary Gland ◽

Mechanism Of Action ◽

Androgen Receptors ◽

Male Rat ◽

Pregnant Rats ◽

Target Organs ◽

Causative Factors ◽

Competitive Action ◽

Androgenic Effect

ABSTRACT Experiments are described dealing with the mechanism of action of 6-chloro-Δ6-1,2α-methylene-17α-hydroxyprogesterone-acetate with regard to its anti-masculine effect on male rat foetuses, when administered to pregnant rats. It was shown that a marked direct anti-androgenic effect due to a competitive action on androgen receptors within the target organs, is probably the explanation of the mechanism of action. It was further shown that an oestrogenic effect or an appreciable inhibition of the pituitary gland respectively, can be ruled out as causative factors in the mechanism of action.

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THE PARATHYROIDS IN CORTICOSTEROID-TREATED PREGNANT RATS AND THEIR OFFSPRING

Acta Endocrinologica ◽

10.1530/acta.0.0530547 ◽

1966 ◽

Vol 53 (4) ◽

pp. 547-552 ◽

Cited By ~ 1

Author(s):

C. Göran Hansson ◽

Lennart Angervall

Keyword(s):

Mitotic Rate ◽

Pregnant Rats

ABSTRACT Geometrically increasing doses of cortisone (0.5, 1.5 and 4.5 mg twice daily) were injected into pregnant rats, and the volume, nuclear diameters and mitotic rate of the maternal parathyroids as well as the parathyroid volume and mitotic rate in the foetuses were determined. The nuclear diameters were if anything smaller and the mitotic rate tended to decrease in the cortisone treated groups. There were no significant differences between the parathyroid volumes of the foetuses in the control and cortisone-treated groups. Thus, it seems that the development of the rat foetal parathyroids and the morphology of the maternal parathyroids are little affected if at all, by cortisone.

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THE FALL OF BLOOD PRESSURE FOLLOWING INDUCTION OF DECIDUOMATA IN STEROID HYPERTENSIVE RATS RECEIVING PROGESTERONE

Acta Endocrinologica ◽

10.1530/acta.0.0590227 ◽

1968 ◽

Vol 59 (2) ◽

pp. 227-234 ◽

Cited By ~ 1

Author(s):

H. C. Moore ◽

I. Cserhati ◽

F. P. Biliczki

Keyword(s):

Blood Pressure ◽

Hypotensive Effect ◽

Hypertensive Rats ◽

Pregnant Rats ◽

Hypertensive Rat ◽

Equivalent Time ◽

Metrial Gland ◽

Blood Pressure Responses ◽

A Minor ◽

Maternal Decidua

ABSTRACT Experimental deciduomata and progesterone together lower the blood pressure in the steroid hypertensive rat from the 5th to 10th day of decidual growth i. e. from the 10th to 15th day of pseudopregnancy. This would suggest that the fall of blood pressure at an equivalent time of gestation in hypertensive pregnant rats could be due to the maternal decidua under the influence of progesterone. It is further considered that the metrial gland of the deciduoma is more likely to be responsible for the hypotensive effect and by comparison that the metrial gland is implicated in the hypotensive effect of pregnancy. Progesterone alone also exerts a minor hypotensive effect in those animals in which a nephrectomy forms part of the hypertension regimen and indicates one way in which a maternal renal factor could influence blood pressure responses in hypertensive pregnant rats.

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Changes in lipid peroxidation during pregnancy and after delivery in rats: effect of pinealectomy

Reproduction ◽

10.1530/reprod/119.1.143 ◽

2000 ◽

pp. 143-149 ◽

Cited By ~ 9

Author(s):

RM Sainz ◽

RJ Reiter ◽

JC Mayo ◽

J Cabrera ◽

DX Tan ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Oxidative Damage ◽

Energy Demand ◽

Physiological State ◽

High Energy ◽

Free Radical Scavengers ◽

Radical Scavengers ◽

Oxygen Requirement ◽

Pregnant Rats

Pregnancy is a physiological state accompanied by a high energy demand of many bodily functions and an increased oxygen requirement. Because of the increased intake and utilization of oxygen, increased levels of oxidative stress would be expected. In the present study, the degree of lipid peroxidation was examined in different tissues from non-pregnant and pregnant rats after the delivery of their young. Melatonin and other indole metabolites are known to be direct free radical scavengers and indirect antioxidants. Thus the effect of pinealectomy at 1 month before pregnancy on the accumulation of lipid damage was investigated in non-pregnant and pregnant rats after the delivery of their young. Malonaldehyde and 4-hydroxyalkenal concentrations were measured in the lung, uterus, liver, brain, kidney, thymus and spleen from intact and pinealectomized pregnant rats soon after birth of their young and at 14 and 21 days after delivery. The same parameters were also evaluated in intact and pinealectomized non-pregnant rats. Shortly after delivery, lipid oxidative damage was increased in lung, uterus, brain, kidney and thymus of the mothers. No differences were detected in liver and spleen. Pinealectomy enhanced this effect in the uterus and lung. It is concluded that during pregnancy high levels of oxidative stress induce an increase in oxidative damage to lipids, which in some cases is inhibited by the antioxidative actions of pineal indoles.

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