Theoretical Construction of Thermodynamic Relations for a Solvent-controlled Phase Transition to Improve the Bioavailability of Drugs: A Case Study of Indomethacin

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Spectroscopy Conference
2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Sebastian Baum ◽  
Marcela Carena ◽  
Nausheen R. Shah ◽  
Carlos E. M. Wagner ◽  
Yikun Wang

Abstract Electroweak baryogenesis is an attractive mechanism to generate the baryon asymmetry of the Universe via a strong first order electroweak phase transition. We compare the phase transition patterns suggested by the vacuum structure at the critical temperatures, at which local minima are degenerate, with those obtained from computing the probability for nucleation via tunneling through the barrier separating local minima. Heuristically, nucleation becomes difficult if the barrier between the local minima is too high, or if the distance (in field space) between the minima is too large. As an example of a model exhibiting such behavior, we study the Next-to-Minimal Supersymmetric Standard Model, whose scalar sector contains two SU(2) doublets and one gauge singlet. We find that the calculation of the nucleation probabilities prefers different regions of parameter space for a strong first order electroweak phase transition than the calculation based solely on the critical temperatures. Our results demonstrate that analyzing only the vacuum structure via the critical temperatures can provide a misleading picture of the phase transition patterns, and, in turn, of the parameter space suitable for electroweak baryogenesis.


2015 ◽  
Vol 35 (6) ◽  
Author(s):  
蔡建堤 CAI Jiandi ◽  
陈方平 CHEN Fangping ◽  
吴建绍 WU Jianshao ◽  
刘勇 LIU Yong ◽  
沈长春 SHEN Changchun ◽  
...  

2019 ◽  
Vol 67 (11) ◽  
pp. 893-903
Author(s):  
Arash Shahbakhsh ◽  
Astrid Nieße

Abstract Information and communication technology (ICT) and the technology of coupling points including power-to-gas (PtG), power-to-heat (PtH) and combined heat and power (CHP) reshape future energy systems fundamentally. To study the resulting multimodal smart energy system, a proposed method is to separate the behavior of the component layer from the control layer. The component layer includes pipelines, power-lines, generators, loads, coupling points and generally all components through which energy flows. In the work at hand, a model is presented to analyze the operational behavior of the component layer. The modeling problem is formulated as state and phase transition functions, which present the external commands and internal dynamics of system. Phase transition functions are approximated by ordinary differential equations, which are solved with integral methods. State transition functions are nonlinear algebraic functions, which are solved numerically and iteratively with a modified Newton–Raphson method. In a proof-of-concept case study, a scenario shows the expected multi-sector effects based on evaluated models.


Author(s):  
Keynayanna Késsia Costa Fortaleza ◽  
Éverton Oliveira Cabral ◽  
Larissa Bortoluzzi Rigo

Since the 1980s, an intense process of Midiatization and Regionalization of Communication has been observed in Brazil. Such sociocultural, economic and technological changes reflect on the evolution of media processes, being present in the modes of organization and functioning of the media with society. This article, produced through a case study (YIN, 2005), addresses the business and communication altogether of the Claudino Group, Coca-Cola and Fiat, which through the structuring and development of a regional media retain public and establish a positive image of its brand in the Brazilian media context. For theoretical construction purposes, the concepts of the following authors were considered: Fadul (2007), Neto (2008), Peruzzo (2009), Lima (2005), Melo (2006), Braga (2012) and Branco (2012). We note that the actions developed in the context of the communication of both organizations ended up building and implementing new interactional processes, also triggering the influence of the organization on the culture of a given locality. (Image by Sasin Tipchai from Pixabay)


2011 ◽  
Vol 226 (12) ◽  
pp. 956-962 ◽  
Author(s):  
Melanie Müller ◽  
Robert E. Dinnebier ◽  
Susan Schorr

2014 ◽  
Vol 70 (a1) ◽  
pp. C902-C902
Author(s):  
Ian Hutchison ◽  
Amit Delori ◽  
William Marshall ◽  
Iain Oswald

The role of pressure-transmitting media is to ensure that uniaxial pressure is translated into a hydrostatic pressure. Many of these media are useful to high-pressure scientists for a limited pressure regimen out with which the media becomes non-hydrostatic in nature. For most pressure studies the role of the media is purely to apply the pressure however in recent years the media has been used to dissolve compounds of interest before precipitating these out by the application of pressure. Previous work of Fabbiani et al gave a wonderful example of how changing the concentration of the solution and hence the pressure of precipitation can isolate new polymorphs of the pharmaceutical material, piracetam.[1] It is known that the structural changes that occur in a material may depend on the pressure that is applied i.e. phase transition may not occur under hydrostatic regime whereas they will if put under non-hydrostatic environments. Our present studies have been exploring the role of pressure in the polymerisation reaction of simple systems and structurally characterising the materials preceding these events.[2] These studies have provided extra structural insight into the previous Raman studies.[3] We present here a case study where the role of the pressure-transmitting medium extends beyond just application of pressure but where, depending on the medium chosen, new phases can be observed. This work has been conducted at the Pearl beamline at ISIS Neutron Facility in UK.


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