Harmful Impacts of Bisphenol A on Adult Albino Rat Prostate and the Possible Effect of Recovery: Histological and Immunohistochemical study

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Joseph Aziz ◽  
Rania Moawad
Keyword(s):  
Bisphenol A ◽  
Immunohistochemical Study ◽  
Albino Rat ◽  
Rat Prostate

Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat

2015 ◽  
Vol 61 ◽  
pp. 570-574
Author(s):  
B. N. Hassan ◽  
A. S. Alazzouni ◽  
N. A. Al Jalaud
Keyword(s):  
Bisphenol A ◽  
Immunohistochemical Study ◽  
Albino Rat

scholarly journals The Possible Therapeutic Role of Platelet Rich Plasma on a Model of Osteoarthritis in Male Albino Rat. Histological and Immunohistochemical Study

2019 ◽  
Vol 42 (3) ◽  
pp. 554-566
Author(s):  
Nebal Gamal ◽  
Naglaa Abou-Rabia ◽  
Faika El Ebiary ◽  
Gehan Khalaf ◽  
Mona Raafat
Keyword(s):  
Immunohistochemical Study ◽  
Platelet Rich Plasma ◽  
Albino Rat ◽  
Therapeutic Role

scholarly journals Histological and immunohistochemical study on the role of mesenchymal stem cells in the repair of experimentally induced skin burn in adult male albino rat

QJM ◽  
2018 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
D Ahmed Yousef Yehia ◽  
N Mohamed El Shakaa ◽  
M Abd Elrahman Ahmed ◽  
G Abd El Khalek Ibrahim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adult Male ◽  
Immunohistochemical Study ◽  
Skin Burn ◽  
Albino Rat ◽  
Experimentally Induced

scholarly journals Bisphenol A Disrupts HNF4α-Regulated Gene Networks Linking to Prostate Preneoplasia and Immune Disruption in Noble Rats

Endocrinology ◽  
2016 ◽  
Vol 157 (1) ◽  
pp. 207-219 ◽  
Author(s):  
Hung-Ming Lam ◽  
Shuk-Mei Ho ◽  
Jing Chen ◽  
Mario Medvedovic ◽  
Neville Ngai Chung Tam
Keyword(s):  
Bisphenol A ◽  
Gene Networks ◽  
Intraepithelial Neoplasia ◽  
High Dose ◽  
Low Grade ◽  
Treatment Groups ◽  
Adult Rat ◽  
Genome Wide ◽  
17Β Estradiol ◽  
Rat Prostate

Abstract Exposure of humans to bisphenol A (BPA) is widespread and continuous. The effects of protracted exposure to BPA on the adult prostate have not been studied. We subjected Noble rats to 32 weeks of BPA (low or high dose) or 17β-estradiol (E2) in conjunction with T replenishment. T treatment alone or untreated groups were used as controls. Circulating T levels were maintained within the physiological range in all treatment groups, whereas the levels of free BPA were elevated in the groups treated with T+low BPA (1.06 ± 0.05 ng/mL, P < .05) and T+high BPA (10.37 ± 0.43 ng/mL, P < .01) when compared with those in both controls (0.1 ± 0.05 ng/mL). Prostatic hyperplasia, low-grade prostatic intraepithelial neoplasia (PIN), and marked infiltration of CD4+ and CD8+ T cells into the PIN epithelium (P < .05) were observed in the lateral prostates (LPs) of T+low/high BPA-treated rats. In contrast, only hyperplasia and high-grade PIN, but no aberrant immune responses, were found in the T+E2-treated LPs. Genome-wide transcriptome analysis in LPs identified differential changes between T+BPA vs T+E2 treatment. Expression of multiple genes in the regulatory network controlled by hepatocyte nuclear factor 4α was perturbed by the T+BPA but not by the T+E2 exposure. Collectively these findings suggest that the adult rat prostate, under a physiologically relevant T environment, is susceptible to BPA-induced transcriptomic reprogramming, immune disruption, and aberrant growth dysregulation in a manner distinct from those caused by E2. They are more relevant to our recent report of higher urinary levels BPA found in patients with prostate cancer than those with benign disease.

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