Toxic Effects of Cypermethrin on Sperms and The Possible Protective Role of Vitamines C and E : An Invitro Study

2012 ◽  
Vol 20 (2) ◽  
pp. 101-119
Author(s):  
Sahar El-Dakroory ◽  
Amal El-Bakary ◽  
Adel Zalata ◽  
Hussien Abd Elaziz
Keyword(s):  
Protective Role ◽  
Toxic Effects

scholarly journals Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6610
Author(s):  
Ana T. Rufino ◽  
Ana Ramalho ◽  
Adelaide Sousa ◽  
José Miguel P. Ferreira de Oliveira ◽  
Paulo Freitas ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Protective Action ◽  
Cell Types ◽  
Protective Role ◽  
Toxic Effects ◽  
Oral Exposure ◽  
Dietary Flavonoids ◽  
Harmful Effects ◽  
Human Intestinal Cells

Silver nanoparticles (AgNP) have been increasingly incorporated into food-related and hygiene products for their unique antimicrobial and preservative properties. The consequent oral exposure may then result in unpredicted harmful effects in the gastrointestinal tract (GIT), which should be considered in the risk assessment and risk management of these materials. In the present study, the toxic effects of polyethyleneimine (PEI)-coated AgNP (4 and 19 nm) were evaluated in GIT-relevant cells (Caco-2 cell line as a model of human intestinal cells, and neutrophils as a model of the intestinal inflammatory response). This study also evaluated the putative protective action of dietary flavonoids against such harmful effects. The obtained results showed that AgNP of 4 and 19 nm effectively induced Caco-2 cell death by apoptosis with concomitant production of nitric oxide, irrespective of the size. It was also observed that AgNP induced human neutrophil oxidative burst. Interestingly, some flavonoids, namely quercetin and quercetagetin, prevented the deleterious effects of AgNP in both cell types. Overall, the data of the present study provide a first insight into the promising protective role of flavonoids against the potentially toxic effects of AgNP at the intestinal level.

scholarly journals The protective role of virgin coconut oil on the alloxan-induced oxidative stress in the liver, kidneys and heart of diabetic rats

2019 ◽  
Vol 10 (4) ◽  
pp. 2114-2124 ◽  
Author(s):  
Siniša Đurašević ◽  
Nebojša Jasnić ◽  
Marko Prokić ◽  
Ilijana Grigorov ◽  
Vesna Martinović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coconut Oil ◽  
Protective Role ◽  
Diabetic Rats ◽  
Toxic Effects ◽  
Virgin Coconut Oil ◽  
Tissue Specific

Our results show that VCO supplementation ameliorates some toxic effects of alloxan induced diabetes, and that the changes are tissue specific.

A Protective Role of Pyridoxin Against the Toxic Effects of P

1952 ◽  
Vol 79 (3) ◽  
pp. 494-497 ◽  
Author(s):  
C. Artom ◽  
W. E. Cornatzer ◽  
G. T. Harrell
Keyword(s):  
Protective Role ◽  
Toxic Effects

Evaluation of Toxic Effects of Novel Platinum (IV) Complexes in Female Rat Liver: Potential Protective Role of Resveratrol

2020 ◽  
Author(s):  
Milica G. Paunović ◽  
Miloš M. Matić ◽  
Vesna D. Stanković ◽  
Marija D. Milošević ◽  
Verica V. Jevtić ◽  
...  
Keyword(s):  
Rat Liver ◽  
Protective Role ◽  
Toxic Effects ◽  
Female Rat

scholarly journals Protective role of curcumin against the toxic effects of cyclophosphamide in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9

2012 ◽  
Vol 2 (1) ◽  
pp. 2 ◽  
Author(s):  
Yasir Hasan Siddique
Keyword(s):  
Drosophila Melanogaster ◽  
Tissue Damage ◽  
Protective Role ◽  
Toxic Effects ◽  
Hsp70 Expression ◽  
The Third ◽  
Dose Dependent ◽  
Transgenic Drosophila ◽  
Third Instar Larvae

In the present study the effects of curcumin was studied against the toxic effects induced by 0.025 and 0.050 ml/ml of cyclophosphamide (CP) in the third instar larvae of transgenic <em>Drosophila melanogaster (hsp70-lacZ)Bg9</em> using hsp70 expression and dye exclusion test as a parameter. The exposure of the third instar larvae to 0.025ml/ml of CP along with 1, 5 and 10 mg/ml of curcumin results in the dose dependent significant decrease in the <em>hsp70</em> expression and tissue damage for 12, 24 and 48hr of duration. Similar results were obtained with the exposure of third instar larvae to 0.050 ml/ml of CP along with 1, 5 and 10 mg/ml of curcumin. The selected doses of curcumin i.e. 1, 5 and 10 mg/ml were not toxic but reduced significantly the expression of <em>hsp70</em> and tissue damage induced by CP. The results of the present study suggest that the curcumin has a protective role against the toxic effects of CP in the third instar larvae of transgenic <em>Drosophila melanogaster (hsp70-lacZ)Bg9</em>.

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