The Role of Vitamin D on Fluoxetine Induced Testicular Toxicity in Adult Male Rats.

Abstract Diabetes mellitus (DM) represents a widespread metabolic disease with a well-known neurotoxicity in both central and peripheral nervous systems. Oxymatrine is a traditional Chinese herbal medicine that has various pharmacological activities including; anti-oxidant, anti-apoptotic and anti-inflammatory potentials. The present work aimed to study the impact of diabetes mellitus on the cerebellar cortex of adult male albino rat and to evaluate the potential protective role of oxymatrine using different histological methods. Fifty-five adult male rats were randomly divided into three groups: group I served as control, group II was given oxymatrine (80 mg/kg/day) orally for 8 weeks and group III was given a single dose of streptozotocin (50mg/kg) intaperitoneally to induce diabetes. Then diabetic rats were subdivided into two subgroups: subgroup IIIa that received no additional treatment and subgroup IIIb that received oxymatrine similar to group II. The diabetic group revealed numerous changes in the Purkinje cell layer in the form of multilayer arrangement of Purkinje cells, shrunken cells with deeply stained nuclei as well as focal loss of the Purkinje cells. A significant increment in GFAP and synaptophysin expression was reported. Transmission electron microscopy showed irregularity and splitting of myelin sheaths in the molecular layer, dark shrunken Purkinje cells with ill-defined nuclei, dilated Golgi saccules and dense granule cells with irregular nuclear outlines in the granular layer. In contrast, these changes were less evident in diabetic rats that received oxymatrine. In conclusion, Oxymatrine could protect the cerebellar cortex against changes induced by DM.

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The potential protective role of taurine against 5-fluorouracil-induced nephrotoxicity in adult male rats

Experimental and Toxicologic Pathology ◽

10.1016/j.etp.2017.01.012 ◽

2017 ◽

Vol 69 (5) ◽

pp. 265-274 ◽

Cited By ~ 9

Author(s):

Hany N. Yousef ◽

Hanaa R. Aboelwafa

Keyword(s):

Adult Male ◽

Protective Role ◽

Male Rats

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THE ROLE OF ALKALINE PHOSPHATASE IN INTESTINAL ABSORPTION: IV. THE EFFECTS OF VARIOUS PROTEINS ON LEVELS OF THE ENZYME IN INTESTINAL MUCOSA

Canadian Journal of Biochemistry and Physiology ◽

10.1139/y55-013 ◽

1955 ◽

Vol 33 (1) ◽

pp. 89-92 ◽

Cited By ~ 1

Author(s):

Jules Tuba ◽

Nester Dickie

Keyword(s):

Alkaline Phosphatase ◽

Intestinal Absorption ◽

Intestinal Mucosa ◽

Adult Male ◽

Wheat Gluten ◽

Male Rats ◽

Dietary Proteins ◽

Intestinal Alkaline Phosphatase ◽

Egg Albumin

Fasted adult male rats were used to study the effect of dietary proteins on intestinal alkaline phosphatase. Groups of animals were offered one of several proteins; lactalbumin, egg albumin, zein, gelatin, wheat gluten, casein, and vitellin. Control animals had cellulose fed to them. The rats were sacrificed six hours after they were given the different diets. Alkaline phosphatase determinations with intestinal homogenates indicated that the two phosphoproteins, casein and vitellin, elevated levels of the enzyme significantly above fasting levels. Possible interpretations of these findings are discussed.

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